scholarly journals O2-03-01: Fractal analysis of amyloid plaques in Alzheimer's disease patients and mouse models

2009 ◽  
Vol 5 (4S_Part_4) ◽  
pp. P107-P107
Author(s):  
Samir Kumar-Singh ◽  
Daniel Pirici ◽  
Christine Van Broeckhoven
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Mouse Models ◽  
Fractal Analysis ◽  
Amyloid Plaques

Fractal analysis of amyloid plaques in Alzheimer's disease patients and mouse models

2011 ◽  
Vol 32 (9) ◽  
pp. 1579-1587 ◽  
Author(s):  
Daniel Pirici ◽  
Caroline Van Cauwenberghe ◽  
Christine Van Broeckhoven ◽  
Samir Kumar-Singh
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Mouse Models ◽  
Fractal Analysis ◽  
Amyloid Plaques

scholarly journals Contrast-enhanced MR microscopy of amyloid plaques in five mouse models of amyloidosis and in human Alzheimer’s disease brains

2017 ◽  
Vol 7 (1) ◽  
Author(s):  
Clémence Dudeffant ◽  
Matthias Vandesquille ◽  
Kelly Herbert ◽  
Clément M. Garin ◽  
Sandro Alves ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Mouse Models ◽  
Amyloid Plaques ◽  
Mr Microscopy ◽  
Contrast Enhanced

P2-014: In vitro study on Pittsburgh Compound-B (PIB) binding to brain amyloid plaques in mouse models of Alzheimer's Disease (AD)

2011 ◽  
Vol 7 ◽  
pp. S311-S311
Author(s):  
Zhizhen Zeng ◽  
Tsing-Bau Chen ◽  
Brett Connolly ◽  
Patricia Miller ◽  
Stacey O'Malley ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Mouse Models ◽  
In Vitro Study ◽  
Amyloid Plaques ◽  
Vitro Study ◽  
Pittsburgh Compound B

CONTRAST-ENHANCED MR MICROSCOPY OF AMYLOID PLAQUES IN FIVE MOUSE MODELS OF ALZHEIMER'S DISEASE: COMPARISON WITH AMYLOID PLAQUE DETECTION IN HUMAN BRAINS

2017 ◽  
Vol 13 (7) ◽  
pp. P920-P921
Author(s):  
Clémence Dudeffant ◽  
Matthias Vandesquille ◽  
Marc Dhenain ◽  
Sandro Alves ◽  
Emmanuel Comoy ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Mouse Models ◽  
Amyloid Plaques ◽  
Amyloid Plaque ◽  
Mr Microscopy ◽  
Contrast Enhanced ◽  
Human Brains ◽  
Plaque Detection

scholarly journals Detection of amyloid plaques in mouse models of Alzheimer's disease by magnetic resonance imaging

2004 ◽  
Vol 51 (3) ◽  
pp. 452-457 ◽  
Author(s):  
Jiangyang Zhang ◽  
Paul Yarowsky ◽  
Marcia N. Gordon ◽  
Giovanni Di Carlo ◽  
Sanjay Munireddy ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Magnetic Resonance ◽  
Mouse Models ◽  
Amyloid Plaques ◽  
Resonance Imaging

scholarly journals Impaired astrocytic Ca2+ signalling in awake Alzheimer's disease transgenic mice

2021 ◽  
Author(s):  
Knut Sindre Åbjørsbråten ◽  
Gry H. E. Syverstad Skaaraas ◽  
Céline Cunen ◽  
Daniel M. Bjørnstad ◽  
Kristin M. Gullestad Binder ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Transgenic Mice ◽  
Mouse Models ◽  
Amyloid Plaques ◽  
Cognitive Dysfunctions ◽  
Event Based ◽  
And Behavior

Increased astrocytic Ca2+ signaling related to amyloid plaques has been shown in Alzheimer's disease mouse models, but to date no reports have characterized behaviorally induced astrocytic Ca2+ signalling in such mice without the confounding effects of anesthesia. Here, we employ an event-based algorithm to assess astrocytic Ca2+ signals in the neocortex of awake-behaving tg-ArcSwe mice and non-transgenic wildtype littermates while monitoring pupil responses and behavior. We demonstrate an attenuated astrocytic Ca2+ response to locomotion and an uncoupling of pupil responses and astrocytic Ca2+ signalling in 15-months old plaque-bearing mice. This points to a potential decoupling of neuromodulatory activation and astrocytic Ca2+ activity, which may account for some of the cognitive dysfunctions observed in Alzheimer’s disease.

scholarly journals Elevated copper in the amyloid plaques and iron in the cortex are observed in mouse models of Alzheimer's disease that exhibit neurodegeneration

2013 ◽  
Vol 2 (2) ◽  
pp. 129-139 ◽  
Author(s):  
Megan W. Bourassa ◽  
Andreana C. Leskovjan ◽  
Ryan V. Tappero ◽  
Erik R. Farquhar ◽  
Carol A. Colton ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Mouse Models ◽  
Amyloid Plaques

scholarly journals Nanoparticulate Radiolabelled Quinolines Detect Amyloid Plaques in Mouse Models of Alzheimer's Disease

2009 ◽  
Vol 2009 ◽  
pp. 1-8 ◽  
Author(s):  
Celeste A. Roney ◽  
Veera Arora ◽  
Padmakar V. Kulkarni ◽  
Peter P. Antich ◽  
Frederick J. Bonte
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Transgenic Mice ◽  
Mouse Models ◽  
Amyloid Plaques ◽  
Brain Uptake ◽  
Amyloid Peptides ◽  
Storage Phosphor

Detecting aggregated amyloid peptides (Aβplaques) presents targets for developing biomarkers of Alzheimer's disease (AD). Polymeric n-butyl-2-cyanoacrylate (PBCA) nanoparticles (NPs) were encapsulated with radiolabelled amyloid affinityI125-clioquinol (CQ, 5-chloro-7-iodo-8-hydroxyquinoline) as in vivo probes.I125-CQ-PBCA NPs crossed the BBB (2.3±0.9 ID/g) (P<.05) in the WT mouse (N= 210), compared toI125-CQ (1.0±0.4 ID/g).I125-CQ-PBCA NP brain uptake increased in AD transgenic mice (APP/PS1) versus WT (N= 38;2.54×105±5.31×104 DLU/mm2; versus1.98×105±2.22×104 DLU/mm2) and in APP/PS1/Tau. Brain increases were in mice intracranially injected with aggregated Aβ42peptide (N= 17;7.19×105±1.25×105 DLU/mm2), versus WT (6.07×105±7.47×104 DLU/mm2). Storage phosphor imaging and histopathological staining of the plaques,Fe2+andCu2+, validated results.I125-CQ-PBCA NPs have specificity for Aβin vitro and in vivo and are promising as in vivo SPECT (I123), or PET (I124) amyloid imaging agents.

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