scholarly journals Contrast-enhanced MR microscopy of amyloid plaques in five mouse models of amyloidosis and in human Alzheimer’s disease brains

2017 ◽  
Vol 7 (1) ◽  
Author(s):  
Clémence Dudeffant ◽  
Matthias Vandesquille ◽  
Kelly Herbert ◽  
Clément M. Garin ◽  
Sandro Alves ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Mouse Models ◽  
Amyloid Plaques ◽  
Mr Microscopy ◽  
Contrast Enhanced

CONTRAST-ENHANCED MR MICROSCOPY OF AMYLOID PLAQUES IN FIVE MOUSE MODELS OF ALZHEIMER'S DISEASE: COMPARISON WITH AMYLOID PLAQUE DETECTION IN HUMAN BRAINS

2017 ◽  
Vol 13 (7) ◽  
pp. P920-P921
Author(s):  
Clémence Dudeffant ◽  
Matthias Vandesquille ◽  
Marc Dhenain ◽  
Sandro Alves ◽  
Emmanuel Comoy ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Mouse Models ◽  
Amyloid Plaques ◽  
Amyloid Plaque ◽  
Mr Microscopy ◽  
Contrast Enhanced ◽  
Human Brains ◽  
Plaque Detection

scholarly journals O2-03-01: Fractal analysis of amyloid plaques in Alzheimer's disease patients and mouse models

2009 ◽  
Vol 5 (4S_Part_4) ◽  
pp. P107-P107
Author(s):  
Samir Kumar-Singh ◽  
Daniel Pirici ◽  
Christine Van Broeckhoven
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Mouse Models ◽  
Fractal Analysis ◽  
Amyloid Plaques

P2-014: In vitro study on Pittsburgh Compound-B (PIB) binding to brain amyloid plaques in mouse models of Alzheimer's Disease (AD)

2011 ◽  
Vol 7 ◽  
pp. S311-S311
Author(s):  
Zhizhen Zeng ◽  
Tsing-Bau Chen ◽  
Brett Connolly ◽  
Patricia Miller ◽  
Stacey O'Malley ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Mouse Models ◽  
In Vitro Study ◽  
Amyloid Plaques ◽  
Vitro Study ◽  
Pittsburgh Compound B

scholarly journals Detection of amyloid plaques in mouse models of Alzheimer's disease by magnetic resonance imaging

2004 ◽  
Vol 51 (3) ◽  
pp. 452-457 ◽  
Author(s):  
Jiangyang Zhang ◽  
Paul Yarowsky ◽  
Marcia N. Gordon ◽  
Giovanni Di Carlo ◽  
Sanjay Munireddy ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Magnetic Resonance ◽  
Mouse Models ◽  
Amyloid Plaques ◽  
Resonance Imaging

Fractal analysis of amyloid plaques in Alzheimer's disease patients and mouse models

2011 ◽  
Vol 32 (9) ◽  
pp. 1579-1587 ◽  
Author(s):  
Daniel Pirici ◽  
Caroline Van Cauwenberghe ◽  
Christine Van Broeckhoven ◽  
Samir Kumar-Singh
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Mouse Models ◽  
Fractal Analysis ◽  
Amyloid Plaques

scholarly journals Impaired astrocytic Ca2+ signalling in awake Alzheimer's disease transgenic mice

2021 ◽  
Author(s):  
Knut Sindre Åbjørsbråten ◽  
Gry H. E. Syverstad Skaaraas ◽  
Céline Cunen ◽  
Daniel M. Bjørnstad ◽  
Kristin M. Gullestad Binder ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Transgenic Mice ◽  
Mouse Models ◽  
Amyloid Plaques ◽  
Cognitive Dysfunctions ◽  
Event Based ◽  
And Behavior

Increased astrocytic Ca2+ signaling related to amyloid plaques has been shown in Alzheimer's disease mouse models, but to date no reports have characterized behaviorally induced astrocytic Ca2+ signalling in such mice without the confounding effects of anesthesia. Here, we employ an event-based algorithm to assess astrocytic Ca2+ signals in the neocortex of awake-behaving tg-ArcSwe mice and non-transgenic wildtype littermates while monitoring pupil responses and behavior. We demonstrate an attenuated astrocytic Ca2+ response to locomotion and an uncoupling of pupil responses and astrocytic Ca2+ signalling in 15-months old plaque-bearing mice. This points to a potential decoupling of neuromodulatory activation and astrocytic Ca2+ activity, which may account for some of the cognitive dysfunctions observed in Alzheimer’s disease.

scholarly journals Elevated copper in the amyloid plaques and iron in the cortex are observed in mouse models of Alzheimer's disease that exhibit neurodegeneration

2013 ◽  
Vol 2 (2) ◽  
pp. 129-139 ◽  
Author(s):  
Megan W. Bourassa ◽  
Andreana C. Leskovjan ◽  
Ryan V. Tappero ◽  
Erik R. Farquhar ◽  
Carol A. Colton ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Mouse Models ◽  
Amyloid Plaques
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