O4-03-01: Age-dependent impairment of cognitive and synaptic function in transgenic mouse model of tau pathology (htau mouse)

2009 ◽  
Vol 5 (4S_Part_5) ◽  
pp. P153-P154
Author(s):  
Manuela Polydoro ◽  
Christopher M. Acker ◽  
Karen Duff ◽  
Pablo E. Castillo ◽  
Peter Davies
Keyword(s):  
Mouse Model ◽  
Transgenic Mouse ◽  
Transgenic Mouse Model ◽  
Synaptic Function ◽  
Tau Pathology ◽  
Age Dependent

Deletion of murine tau gene increases tau aggregation in a human mutant tau transgenic mouse model

2010 ◽  
Vol 38 (4) ◽  
pp. 1001-1005 ◽  
Author(s):  
Kunie Ando ◽  
Karelle Leroy ◽  
Céline Heraud ◽  
Anna Kabova ◽  
Zehra Yilmaz ◽  
...  
Keyword(s):  
Mouse Model ◽  
Transgenic Mouse ◽  
Double Mutant ◽  
Transgenic Mouse Model ◽  
Tau Proteins ◽  
Dependent Manner ◽  
Age Dependent ◽  
Ad Alzheimer’S Disease ◽  
Tau Aggregation ◽  
The Brain

We have reported previously a tau transgenic mouse model (Tg30tau) overexpressing human 4R1N double-mutant tau (P301S and G272V) and that develops AD (Alzheimer's disease)-like NFTs (neurofibrillary tangles) in an age-dependent manner. Since murine tau might interfere with the toxic effects of human mutant tau, we set out to analyse the phenotype of our Tg30tau model in the absence of endogenous murine tau with the aim to reproduce more faithfully a model of human tauopathy. By crossing the Tg30tau line with TauKO (tau-knockout) mice, we have obtained a new mouse line called Tg30×TauKO that expresses only exogenous human double-mutant 4R1N tau. Whereas Tg30×TauKO mice express fewer tau proteins compared with Tg30tau, they exhibit augmented sarkosyl-insoluble tau in the brain and an increased number of Gallyas-positive NFTs in the hippocampus. Taken together, exclusion of murine tau causes accelerated tau aggregation during aging of this mutant tau transgenic model.

scholarly journals Selective knocking out of FynT‐isoform‐attenuated tau pathology, synaptic degeneration and neuroinflammation in P301S mutant human tau transgenic mouse model

2020 ◽  
Vol 16 (S3) ◽  
Author(s):  
Clara Ying Bei Low ◽  
Chingli Lee ◽  
Frances Ting Wei Lim ◽  
Adrian Kian Long Lee ◽  
Juliette Min Huey Lo ◽  
...  
Keyword(s):  
Mouse Model ◽  
Transgenic Mouse ◽  
Transgenic Mouse Model ◽  
Tau Pathology ◽  
Synaptic Degeneration
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