O4-07-06: Higher rate of beta-amyloid accumulation in precuneus in cognitively normal APOE E4 carriers compared to non-carriers

2011 ◽  
Vol 7 ◽  
pp. S697-S698
Author(s):  
Andrei Vlassenko ◽  
Chengjie Xiong ◽  
Alison Goate ◽  
Tammie Benzinger ◽  
John Morris ◽  
...  
Keyword(s):  
Beta Amyloid ◽  
Cognitively Normal ◽  
Amyloid Accumulation

scholarly journals Blunted cerebrovascular response is associated with elevated beta-amyloid

2017 ◽  
Vol 39 (1) ◽  
pp. 89-96 ◽  
Author(s):  
Jason-Flor V Sisante ◽  
Eric D Vidoni ◽  
Kiersten Kirkendoll ◽  
Jaimie Ward ◽  
Yumei Liu ◽  
...  
Keyword(s):  
Processing Speed ◽  
Beta Amyloid ◽  
Moderate Intensity ◽  
Artery Blood Flow ◽  
Amyloid Burden ◽  
Moderate Intensity Exercise ◽  
Velocity Change ◽  
Cognitively Normal ◽  
Positron Emission ◽  
Amyloid Accumulation

The goal of this study was to explore the association of beta-amyloid accumulation and cerebrovascular response (CVR) in cognitively normal older adults. Beta-amyloid accumulation was characterized with [18F] Florbetapir positron emission tomography scans. CVR was calculated as middle cerebral artery blood flow velocity change from rest to moderate intensity exercise. We found that individuals with elevated beta-amyloid aggregation had a blunted CVR ( n = 25, age 70.1 ± 4.8; 3.3 ± 3.7 cm/s) compared to non-elevated individuals ( n = 45, age 72.0 ± 4.9; 7.2 ± 5.0 cm/s, p < 0.001). Further, greater beta-amyloid burden was linearly associated with less CVR across all participants (b = −11.7, p < 0.001). Greater CVR and less beta-amyloid burden were associated with processing speed ( p < 0.05). This study is the first to show that CVR from rest to exercise is blunted across increased global beta-amyloid burden.

Centella asiatica Protects Against the Toxic Effects of Intracellular beta-amyloid Accumulation

Planta Medica ◽  
2013 ◽  
Vol 79 (10) ◽  
Author(s):  
N Gray ◽  
J Morré ◽  
J Kelley ◽  
C Maier ◽  
F Stevens ◽  
...  
Keyword(s):  
Centella Asiatica ◽  
Beta Amyloid ◽  
Toxic Effects ◽  
Amyloid Accumulation

P3-470: PAIRED ASSOCIATE LEARNING DEFICITS ASSOCIATED WITH ELEVATED BETA-AMYLOID IN COGNITIVELY NORMAL OLDER ADULTS

2006 ◽  
Vol 14 (7S_Part_24) ◽  
pp. P1300-P1301
Author(s):  
Jenalle E. Baker ◽  
Yen Lim ◽  
Judith Jaeger ◽  
David Ames ◽  
Robert H. Pietrzak ◽  
...  
Keyword(s):  
Older Adults ◽  
Paired Associate ◽  
Beta Amyloid ◽  
Paired Associate Learning ◽  
Associate Learning ◽  
Learning Deficits ◽  
Cognitively Normal

scholarly journals Beta-amyloid burden predicts poorer mnemonic discrimination in cognitively normal older adults

NeuroImage ◽  
2020 ◽  
Vol 221 ◽  
pp. 117199 ◽  
Author(s):  
Christina E. Webb ◽  
Chris M. Foster ◽  
Marci M. Horn ◽  
Kristen M. Kennedy ◽  
Karen M. Rodrigue
Keyword(s):  
Older Adults ◽  
Beta Amyloid ◽  
Amyloid Burden ◽  
Cognitively Normal

Lifetime History of Depression Predicts Increased Beta-Amyloid Accumulation in Patients with Mild Cognitive Impairment

2015 ◽  
Vol 23 (3) ◽  
pp. S147-S150 ◽  
Author(s):  
Jun Ku Chung ◽  
Eric Plitman ◽  
Shinichiro Nakajima ◽  
Tiffany W. Chow ◽  
Mallar Chakravarty ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Beta Amyloid ◽  
Lifetime History ◽  
Amyloid Accumulation ◽  
History Of ◽  
History Of Depression
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