O1-12-06: MHPG as an additional marker for the differentiation of dementia with Lewy bodies from Alzheimer's disease, vascular dementia and frontotemporal dementia

2012 ◽  
Vol 8 (4S_Part_3) ◽  
pp. P107-P107
Author(s):  
Megan Herbert ◽  
Marjolein Aerts ◽  
H. Bea Kuiperij ◽  
Marcel M. Verbeek
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Vascular Dementia ◽  
Frontotemporal Dementia ◽  
Dementia With Lewy Bodies ◽  
Lewy Bodies ◽  
Additional Marker

scholarly journals P.001 Rate of cognitive decline in dementias in patients from rural and remote Saskatchewan

2019 ◽  
Vol 46 (s1) ◽  
pp. S14
Author(s):  
IU Shahab ◽  
A Kirk ◽  
C Karunanayake ◽  
M O’Connell ◽  
D Morgan
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cognitive Decline ◽  
Vascular Dementia ◽  
Frontotemporal Dementia ◽  
Dementia With Lewy Bodies ◽  
Mmse Score ◽  
Lewy Bodies ◽  
Rural And Remote ◽  
Rate Of Decline

Background: To determine whether there is a difference in the average annual rate of decline in Mini Mental Status Examination (MMSE) scores between those with Alzheimer’s disease, vascular dementia, frontotemporal dementia and dementia with Lewy bodies. Methods: We conducted a retrospective chart review of 225 consecutive patients with dementia who attended the Rural and Remote Memory Clinic in Saskatoon, Saskatchewan. The data collected included MMSE scores and demographic information. Statistical analysis with ANOVA compared the average the annual rate of decline in MMSE score between patients with different types of dementia. Results: There was no statistically significant difference in the rate of MMSE score decline between these groups. Patients with frontotemporal dementia and vascular dementia were referred to the clinic at younger ages than those with Alzheimer’s disease and dementia with Lewy bodies. Conclusions: The rate of decline in MMSE did not differ between these four types of dementia. Patients with frontotemporal dementia and vascular dementia often experience cognitive decline earlier in life than those with Alzheimer’s disease and dementia with Lewy bodies.

Frontotemporal dementia and dementia with Lewy bodies in a case-control study of Alzheimer's disease

2009 ◽  
Vol 21 (4) ◽  
pp. 688-695 ◽  
Author(s):  
Olivier Piguet ◽  
Glenda M. Halliday ◽  
Helen Creasey ◽  
G. Anthony Broe ◽  
Jillian J. Kril
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Frontotemporal Dementia ◽  
Clinical Diagnosis ◽  
Dementia With Lewy Bodies ◽  
Case Control Study ◽  
Lewy Bodies ◽  
Case Control ◽  
Dementia Syndrome ◽  
Control Study

ABSTRACTBackground: The clinical presentations in dementia with Lewy bodies (DLB) and frontotemporal dementia (FTD) overlap considerably with that of Alzheimer's disease (AD) despite different pathological processes. Autopsy studies have also shown that multiple brain pathology occurs frequently, even in cases with a single clinical diagnosis. We aimed to determine the frequency of clinical diagnosis of FTD and DLB and the underlying pathology in a well-characterized cohort of patients with a clinical diagnosis of probable or possible AD.Methods: We conducted a retrospective analysis of 170 AD patients (probable AD = 83; possible AD = 87) originally enrolled in a case-control study, 27 with postmortem examination, to establish the number of cases meeting probable diagnosis for FTD and DLB, using a checklist of features compiled from their consensus criteria.Results: 23/83 probable AD cases and 32/87 possible AD cases met probable criteria for another dementia, more commonly DLB than FTD. AD pathology was present in 8/15 probable AD and 8/12 possible AD cases coming to autopsy. DLB pathology was seen in four cases and FTD pathology in eight cases. In the AD cases reaching clinical diagnosis for a second dementia syndrome and coming to autopsy, a minority showed non-AD pathology only.Conclusions: Presence of core clinical features of non-AD dementia syndromes is common in AD. Concordance between clinical and pathological diagnoses of dementia remains variable. We propose that repeat clinical examinations and structural neuroimaging will improve diagnostic accuracy. In addition, clinical diagnostic criteria for the main dementia syndromes require refinement.

Quantifying fluctuation in dementia with Lewy bodies, Alzheimer's disease, and vascular dementia

Neurology ◽  
2000 ◽  
Vol 54 (8) ◽  
pp. 1616-1625 ◽  
Author(s):  
M. P. Walker ◽  
G. A. Ayre ◽  
J. L. Cummings ◽  
K. Wesnes ◽  
I. G. McKeith ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Vascular Dementia ◽  
Dementia With Lewy Bodies ◽  
Lewy Bodies

Validity of current clinical criteria for Alzheimer's disease, vascular dementia and dementia with Lewy bodies

1999 ◽  
Vol 174 (1) ◽  
pp. 45-50 ◽  
Author(s):  
Clive Holmes ◽  
Nigel Cairns ◽  
Peter L. Lantos ◽  
Anthony Mann
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Vascular Dementia ◽  
Dementia With Lewy Bodies ◽  
Lewy Bodies ◽  
Community Based ◽  
Predictive Values ◽  
Clinical Criteria ◽  
Low Prevalence ◽  
Clinical Diagnostic Criteria

BackgroundFollowing the success of the NINCDS–ADRDA criteria for Alzheimer's disease, groups interested in vascular dementia and dementia with Lewy bodies have now adopted similar criteria.AimsTo assess whether the validity of these criteria are influenced by the prevalence of mixed pathologies or by the prevalence rate.MethodA community based postmortem study.ResultsMixed pathologies were common (33.8%). The high specificities obtained for the CDLB and NINDS–AIREN criteria (1.00 and 0.95, respectively) were associated with low sensitivities (0.22 and 0.43, respectively). Low prevalence and the presence of mixed pathologies had a deleterious effect on positive predictive values.ConclusionsCurrent clinical diagnostic criteria are good at detecting pathology per se but not at detecting pure pathology. A large proportion of subjects from the general population fulfilling probable CDLB, probable NINCDS–ADRDA or probable NINDS–AIREN will have mixed pathologies.

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