Alzheimer’s Disease (AD) is a chronic, devastating dysfunction of neurons in the brain
leading to dementia. It mainly arises due to neuronal injury in the cerebral cortex and hippocampus area
of the brain and is clinically manifested as a progressive mental failure, disordered cognitive functions,
personality changes, reduced verbal fluency and impairment of speech. The pathology behind
AD is the formation of intraneuronal fibrillary tangles, deposition of amyloid plaque and decline in
choline acetyltransferase and loss of cholinergic neurons. Tragically, the disease cannot be cured, but
its progression can be halted. Various cholinesterase inhibitors available in the market like Tacrine,
Donepezil, Galantamine, Rivastigmine, etc. are being used to manage the symptoms of Alzheimer’s
disease. The paper’s objective is to throw light not only on the cellular/genetic basis of the disease, but
also on the current trends and various strategies of treatment including the use of phytopharmaceuticals
and nutraceuticals. Enormous literature survey was conducted and published articles of PubMed,
Scifinder, Google Scholar, Clinical Trials.org and Alzheimer Association reports were studied intensively
to consolidate the information on the strategies available to combat Alzheimer’s disease. Currently,
several strategies are being investigated for the treatment of Alzheimer’s disease. Immunotherapies
targeting amyloid-beta plaques, tau protein and neural pathways are undergoing clinical trials.
Moreover, antisense oligonucleotide methodologies are being approached as therapies for its management.
Phytopharmaceuticals and nutraceuticals are also gaining attention in overcoming the symptoms
related to AD. The present review article concludes that novel and traditional therapies simultaneously
promise future hope for AD treatment.
P4-098: Potential of SAC (S-allyl-L-cysteine), a Component of Garlic, as a Novel Drug Target for Alzheimer's Disease (AD) Based on Studies from Primary Neuronal Cultures and In Vivo
