P1-343: A phase II study of the gamma-secretase inhibitor avagacestat (BMS-708163) in predementia Alzheimer's disease

Alzheimer s & Dementia ◽

10.1016/j.jalz.2013.05.569 ◽

2013 ◽

Vol 9 ◽

pp. P283-P283 ◽

Cited By ~ 8

Author(s):

Vlad Coric ◽

Stephen Salloway ◽

Christopher van Dyck ◽

Wendy Kerselaers ◽

Stephen Kaplita ◽

...

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Phase Ii ◽

Phase Ii Study ◽

Gamma Secretase ◽

Secretase Inhibitor ◽

Gamma Secretase Inhibitor

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A phase II study of single-agent RO4929097, a gamma-secretase inhibitor of Notch signaling, in patients with recurrent platinum-resistant epithelial ovarian cancer: A study of the Princess Margaret, Chicago and California phase II consortia

Gynecologic Oncology ◽

10.1016/j.ygyno.2015.03.005 ◽

2015 ◽

Vol 137 (2) ◽

pp. 216-222 ◽

Cited By ~ 32

Author(s):

Ivan Diaz-Padilla ◽

Michelle K. Wilson ◽

Blaise A. Clarke ◽

Hal W. Hirte ◽

Stephen A. Welch ◽

...

Keyword(s):

Ovarian Cancer ◽

Epithelial Ovarian Cancer ◽

Notch Signaling ◽

Phase Ii ◽

Phase Ii Study ◽

Single Agent ◽

Gamma Secretase ◽

Platinum Resistant ◽

Secretase Inhibitor ◽

Gamma Secretase Inhibitor

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P2-015: The gamma-secretase inhibitor BMS-708163 causes dose-dependent reductions in CSF Aβ40 levels in patients with mild-to-moderate Alzheimer's disease (AD)

Alzheimer s & Dementia ◽

10.1016/j.jalz.2011.05.905 ◽

2011 ◽

Vol 7 ◽

pp. S311-S311 ◽

Cited By ~ 5

Author(s):

Charles Albright ◽

Niels Andreasen ◽

Lennart Minthon ◽

Kaj Blennow ◽

Howard Feldman ◽

...

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Gamma Secretase ◽

Secretase Inhibitor ◽

Gamma Secretase Inhibitor ◽

Dose Dependent

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P3-321: APP-selective gamma secretase inhibitor ELND006 effects on brain parenchymal and vascular amyloid beta in the PDAPP mouse model of Alzheimer's disease

Alzheimer s & Dementia ◽

10.1016/j.jalz.2010.05.1822 ◽

2010 ◽

Vol 6 ◽

pp. S546-S546 ◽

Cited By ~ 5

Author(s):

Sally Schroeter ◽

Elizabeth Brigham ◽

Ruth Motter ◽

Chris Nishioka ◽

Terry Guido ◽

...

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Mouse Model ◽

Amyloid Beta ◽

Gamma Secretase ◽

Model Of Alzheimer’S Disease ◽

Secretase Inhibitor ◽

Gamma Secretase Inhibitor ◽

Brain Parenchymal

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P2-302: GSI-953 is a potent APP-selective gamma-secretase inhibitor for the treatment of Alzheimer's disease

Alzheimer s & Dementia ◽

10.1016/j.jalz.2008.05.1379 ◽

2008 ◽

Vol 4 ◽

pp. T461-T461 ◽

Cited By ~ 3

Author(s):

Steven Jacobsen ◽

Thomas Comery ◽

Suzan Aschmies ◽

Hua Zhou ◽

Mei Jin ◽

...

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Gamma Secretase ◽

Secretase Inhibitor ◽

Gamma Secretase Inhibitor

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Synthesis of carbon-14 and stable isotope labeled Avagacestat: a novel gamma secretase inhibitor for the treatment of Alzheimer's disease

Journal of Labelled Compounds and Radiopharmaceuticals ◽

10.1002/jlcr.3224 ◽

2014 ◽

Vol 57 (10) ◽

pp. 600-605 ◽

Cited By ~ 1

Author(s):

Richard C. Burrell ◽

John A. Easter ◽

Michael P. Cassidy ◽

Kevin W. Gillman ◽

Richard E. Olson ◽

...

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Stable Isotope ◽

Gamma Secretase ◽

Carbon 14 ◽

Secretase Inhibitor ◽

Gamma Secretase Inhibitor

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O3-06-07: GSI-953 is a potent APP-selective gamma-secretase inhibitor for the treatment of Alzheimer's disease

Alzheimer s & Dementia ◽

10.1016/j.jalz.2009.05.472 ◽

2009 ◽

Vol 5 (4S_Part_5) ◽

pp. P139-P139 ◽

Cited By ~ 5

Author(s):

Steven Jacobsen ◽

Thomas Comery ◽

Anthony Kreft ◽

Scott Mayer ◽

Margaret Zaleska ◽

...

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Gamma Secretase ◽

Secretase Inhibitor ◽

Gamma Secretase Inhibitor

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A phase II study of the gamma secretase inhibitor RO4929097 in patients with previously treated metastatic pancreatic adenocarcinoma

Investigational New Drugs ◽

10.1007/s10637-014-0083-8 ◽

2014 ◽

Vol 32 (4) ◽

pp. 739-745 ◽

Cited By ~ 64

Author(s):

Ana De Jesus-Acosta ◽

Daniel Laheru ◽

Anirban Maitra ◽

John Arcaroli ◽

Michelle A. Rudek ◽

...

Keyword(s):

Pancreatic Adenocarcinoma ◽

Phase Ii ◽

Phase Ii Study ◽

Gamma Secretase ◽

Metastatic Pancreatic Adenocarcinoma ◽

Secretase Inhibitor ◽

Previously Treated ◽

Gamma Secretase Inhibitor

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P2-195: Cerebral microbleeds in a phase 2 clinical trial of mild-to-moderate Alzheimer's disease with the gamma secretase inhibitor BMS-708163

Alzheimer s & Dementia ◽

10.1016/j.jalz.2011.05.1080 ◽

2011 ◽

Vol 7 ◽

pp. S375-S375

Author(s):

Howard Feldman ◽

Vlad Coric ◽

Reisa Sperling ◽

Steven Greenberg ◽

Richard Bronen ◽

...

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Clinical Trial ◽

Cerebral Microbleeds ◽

Gamma Secretase ◽

Phase 2 ◽

Secretase Inhibitor ◽

Phase 2 Clinical Trial ◽

Gamma Secretase Inhibitor

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Double-Blind, Controlled Phase II Study of a 5-HT6 Receptor Antagonist, SB-742457, in Alzheimer's Disease

Current Alzheimer Research ◽

10.2174/1567210200438162050 ◽

2010 ◽

Vol 999 (999) ◽

pp. 1-12 ◽

Cited By ~ 2

Author(s):

Gareth Maher-Edwards ◽

Marina Zvartau-Hind ◽

A. Jacqueline Hunter ◽

Michael Gold ◽

Gillian Hopton ◽

...

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Receptor Antagonist ◽

Phase Ii ◽

Phase Ii Study ◽

Double Blind

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919MO ACCURACY a phase II trial of AL101, a selective gamma secretase inhibitor, in subjects with recurrent/metastatic (R/M) adenoid cystic carcinoma (ACC) harboring Notch activating mutations (Notchmut)

Annals of Oncology ◽

10.1016/j.annonc.2020.08.1034 ◽

2020 ◽

Vol 31 ◽

pp. S663

Author(s):

R. Ferrarotto ◽

L.J. Wirth ◽

J. Muzaffar ◽

C.P. Rodriguez ◽

B. Xia ◽

...

Keyword(s):

Adenoid Cystic Carcinoma ◽

Phase Ii ◽

Phase Ii Trial ◽

Gamma Secretase ◽

Activating Mutations ◽

Adenoid Cystic ◽

Secretase Inhibitor ◽

Gamma Secretase Inhibitor

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