P3-282: Single oral doses of the novel bace inhibitor bi 1181181 significantly reduce concentrations of cerebrospinal fluid amyloid-beta peptides in healthy subjects

Andreas Borta; Laurent Nicolas; Oliver Kleiner; Klaus-Peter Kammerer; Jennifer Schaible; Kerstin Pietzko; Jana Podhorna; Cornelia Dorner-Ciossek; Joachim Scholpp

doi:10.1016/j.jalz.2015.06.1655

P3-282: Single oral doses of the novel bace inhibitor bi 1181181 significantly reduce concentrations of cerebrospinal fluid amyloid-beta peptides in healthy subjects

Alzheimer s & Dementia ◽

10.1016/j.jalz.2015.06.1655 ◽

2015 ◽

Vol 11 (7S_Part_16) ◽

pp. P740-P740 ◽

Cited By ~ 1

Author(s):

Andreas Borta ◽

Laurent Nicolas ◽

Oliver Kleiner ◽

Klaus-Peter Kammerer ◽

Jennifer Schaible ◽

...

Keyword(s):

Cerebrospinal Fluid ◽

Amyloid Beta ◽

Healthy Subjects ◽

The Novel ◽

Amyloid Beta Peptides ◽

Beta Peptides ◽

Bace Inhibitor ◽

Oral Doses

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P1-192: Automated Mass Spectrometric Method for Identification and Quantitation of Wild-Type and Familial Variants of Amyloid-Beta Peptides in Cerebrospinal Fluid

Alzheimer s & Dementia ◽

10.1016/j.jalz.2016.06.940 ◽

2016 ◽

Vol 12 ◽

pp. P477-P478

Author(s):

J. Grace van der Gugten ◽

Alice C. Fok ◽

Ging-Yuek Robin Hsiung ◽

Mari L. DeMarco

Keyword(s):

Cerebrospinal Fluid ◽

Amyloid Beta ◽

Mass Spectrometric ◽

Spectrometric Method ◽

Mass Spectrometric Method ◽

Wild Type ◽

Amyloid Beta Peptides ◽

Beta Peptides

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P3-187: Complexes of 17beta-hydroxysteroid dehydrogenase type 10 and of amyloid-beta peptides in cerebrospinal fluid of patients with Alzheimer's disease and of neuroinflammatory controls

Alzheimer s & Dementia ◽

10.1016/j.jalz.2010.05.1685 ◽

2010 ◽

Vol 6 ◽

pp. S505-S505

Author(s):

Daniela Řípová ◽

Zdena Krištofiková ◽

Jan Říčný ◽

Kateřina Hegnerová ◽

Markéta Bocková ◽

...

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Cerebrospinal Fluid ◽

Amyloid Beta ◽

Hydroxysteroid Dehydrogenase ◽

Amyloid Beta Peptides ◽

Beta Peptides

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P4-196: The novel BACE inhibitor MK-8931 dramatically lowers cerebrospinal fluid Aβ peptides in healthy subjects following single- and multiple-dose administration

Alzheimer s & Dementia ◽

10.1016/j.jalz.2012.05.1900 ◽

2012 ◽

Vol 8 (4S_Part_19) ◽

pp. P704-P704 ◽

Cited By ~ 32

Author(s):

Mark Forman ◽

John Palcza ◽

Jack Tseng ◽

Jos Leempoels ◽

Steven Ramael ◽

...

Keyword(s):

Cerebrospinal Fluid ◽

Healthy Subjects ◽

Multiple Dose ◽

The Novel ◽

Dose Administration ◽

Aβ Peptides ◽

Multiple Dose Administration ◽

Bace Inhibitor

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Antibody-free detection of amyloid beta peptides biomarkers in cerebrospinal fluid using capillary isotachophoresis coupled with mass spectrometry

Journal of Chromatography A ◽

10.1016/j.chroma.2019.05.006 ◽

2019 ◽

Vol 1601 ◽

pp. 350-356 ◽

Cited By ~ 5

Author(s):

Cédric Crosnier de Lassichère ◽

Thanh Duc Mai ◽

Myriam Taverna

Keyword(s):

Mass Spectrometry ◽

Cerebrospinal Fluid ◽

Amyloid Beta ◽

Capillary Isotachophoresis ◽

Amyloid Beta Peptides ◽

Beta Peptides

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Online Preconcentration in Capillaries by Multiple Large-Volume Sample Stacking: An Alternative to Immunoassays for Quantification of Amyloid Beta Peptides Biomarkers in Cerebrospinal Fluid

Analytical Chemistry ◽

10.1021/acs.analchem.7b03843 ◽

2018 ◽

Vol 90 (4) ◽

pp. 2555-2563 ◽

Cited By ~ 14

Author(s):

Cédric Crosnier de Lassichère ◽

Thanh Duc Mai ◽

Markus Otto ◽

Myriam Taverna

Keyword(s):

Cerebrospinal Fluid ◽

Amyloid Beta ◽

Large Volume ◽

Amyloid Beta Peptides ◽

Sample Stacking ◽

Online Preconcentration ◽

Beta Peptides ◽

Large Volume Sample Stacking

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An UHPLC–MS/MS method for simultaneous quantification of human amyloid beta peptides Aβ1-38, Aβ1-40 and Aβ1-42 in cerebrospinal fluid using micro-elution solid phase extraction

Journal of Chromatography B ◽

10.1016/j.jchromb.2017.10.047 ◽

2017 ◽

Vol 1070 ◽

pp. 82-91 ◽

Cited By ~ 5

Author(s):

Ping-ping Lin ◽

Wei-li Chen ◽

Fei Yuan ◽

Lei Sheng ◽

Yu-jia Wu ◽

...

Keyword(s):

Cerebrospinal Fluid ◽

Solid Phase Extraction ◽

Amyloid Beta ◽

Solid Phase ◽

Phase Extraction ◽

Amyloid Beta Peptides ◽

Simultaneous Quantification ◽

Beta Peptides

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Faculty Opinions recommendation of GSK-3alpha regulates production of Alzheimer's disease amyloid-beta peptides.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1013601.191457 ◽

2003 ◽

Author(s):

Ann Stock

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Amyloid Beta ◽

Amyloid Beta Peptides ◽

Beta Peptides

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Faculty Opinions recommendation of Fibrillar amyloid-beta peptides kill human primary neurons via NADPH oxidase-mediated activation of neutral sphingomyelinase. Implications for Alzheimer's disease.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1021915.249623 ◽

2004 ◽

Author(s):

George Perry

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Nadph Oxidase ◽

Amyloid Beta ◽

Primary Neurons ◽

Amyloid Beta Peptides ◽

Neutral Sphingomyelinase ◽

Beta Peptides

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Amyloid beta peptides and glutamatergic synaptic dysregulation

Experimental Neurology ◽

10.1016/j.expneurol.2007.10.008 ◽

2008 ◽

Vol 210 (1) ◽

pp. 7-13 ◽

Cited By ~ 130

Author(s):

Kodeeswaran Parameshwaran ◽

Muralikrishnan Dhanasekaran ◽

Vishnu Suppiramaniam

Keyword(s):

Amyloid Beta ◽

Amyloid Beta Peptides ◽

Beta Peptides

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Effect of Polycyclic Aromatic Hydrocarbons on the Structure and Oligomerization of Amyloid Beta Peptides: Insights from Molecular Dynamics Simulations

SSRN Electronic Journal ◽

10.2139/ssrn.3979983 ◽

2021 ◽

Author(s):

Samal Kaumbekova ◽

Mehdi Amouei Torkmahalleh ◽

Dhawal Shah

Keyword(s):

Molecular Dynamics ◽

Polycyclic Aromatic Hydrocarbons ◽

Molecular Dynamics Simulations ◽

Amyloid Beta ◽

Aromatic Hydrocarbons ◽

Amyloid Beta Peptides ◽

Beta Peptides ◽

Polycyclic Aromatic ◽

Dynamics Simulations

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