[P1-273]: QUANTIFICATION OF HEPCIDIN-25 IN HUMAN CEREBROSPINAL FLUID: TECHNICAL FEASIBILITY AND BIOLOGICAL RELEVANCE IN NEURODEGENERATIVE DISEASES

2017 ◽  
Vol 13 (7S_Part_7) ◽  
pp. P354-P354
Author(s):  
Constance Delaby ◽  
Pauline Bros ◽  
Jérôme Vialaret ◽  
Cyndi Catteau ◽  
Amandine Moulinier ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Neurodegenerative Diseases ◽  
Technical Feasibility ◽  
Biological Relevance ◽  
Human Cerebrospinal Fluid

scholarly journals An immuno-enrichment free, validated quantification of tau protein in human CSF by LC-MS/MS

2021 ◽  
Author(s):  
Wade Self ◽  
John P. Savaryn ◽  
Khader Awwad ◽  
Michael Schulz
Keyword(s):  
Cerebrospinal Fluid ◽  
Neurodegenerative Diseases ◽  
Tau Protein ◽  
Therapeutic Antibodies ◽  
Alzheimers Disease ◽  
Total Tau ◽  
Human Cerebrospinal Fluid ◽  
Fit For Purpose

Aims: Tau protein is a key target of interest in developing therapeutics for neurodegenerative diseases. Here, we sought to develop a method that quantifies extracellular tau protein concentrations human cerebrospinal fluid (CSF) without antibody-based enrichment strategies. Results: We demonstrate that the fit-for-purpose validated method in Alzheimers Disease CSF is limited to quasi quantitative measures of tau surrogate peptides. We also provide evidence that CSF total Tau measures by LC-MS are feasible in the presence of monoclonal therapeutic antibodies in human CSF. Conclusion: Our Tau LC-MS/MS method is a translational bioanalytical tool for assaying target

scholarly journals Apolipoprotein E allelic influence on human cerebrospinal fluid apolipoproteins

1998 ◽  
Vol 39 (12) ◽  
pp. 2443-2451
Author(s):  
Kathleen S. Montine ◽  
Casey N. Bassett ◽  
Joyce J. Ou ◽  
William R. Markesbery ◽  
Larry L. Swift ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Apolipoprotein E ◽  
Human Cerebrospinal Fluid
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