P2-399: WHOLE BRAIN STRUCTURAL HEALTH IN RELATION TO CARDIOVASCULAR RISK FACTORS: AN EVALUATION USING THE BRAIN ATROPHY AND LESION INDEX

2006 ◽  
Vol 14 (7S_Part_16) ◽  
pp. P856-P856
Author(s):  
Tao Gu ◽  
Min Chen ◽  
Xiaowei Song
Keyword(s):  
Risk Factors ◽  
Cardiovascular Risk ◽  
Cardiovascular Risk Factors ◽  
Brain Atrophy ◽  
Whole Brain ◽  
Structural Health ◽  
The Brain ◽  
Lesion Index

Cardiovascular risk factors are associated with increased lesion burden and brain atrophy in multiple sclerosis

2015 ◽  
pp. jnnp-2014-310051 ◽  
Author(s):  
Natalie Kappus ◽  
Bianca Weinstock-Guttman ◽  
Jesper Hagemeier ◽  
Cheryl Kennedy ◽  
Rebecca Melia ◽  
...  
Keyword(s):  
Risk Factors ◽  
Multiple Sclerosis ◽  
Cardiovascular Risk ◽  
Cardiovascular Risk Factors ◽  
Brain Atrophy

scholarly journals Web‐based assessment of cardiovascular risk factors and cognition in older adults: Findings from the Brain eHealth feasibility study

2020 ◽  
Vol 16 (S10) ◽  
Author(s):  
Kristine Yaffe ◽  
Allison R Kaup ◽  
Amber L Bahorik ◽  
Xochitl Butcher ◽  
Mouna Attarha ◽  
...  
Keyword(s):  
Risk Factors ◽  
Older Adults ◽  
Cardiovascular Risk ◽  
Cardiovascular Risk Factors ◽  
Feasibility Study ◽  
Web Based ◽  
The Brain

scholarly journals Cardiovascular risks impact human brain N-acetylaspartate in regionally specific patterns

2019 ◽  
Vol 116 (50) ◽  
pp. 25243-25249
Author(s):  
Joshua Chiappelli ◽  
Laura M. Rowland ◽  
S. Andrea Wijtenburg ◽  
Hongji Chen ◽  
Andrew A. Maudsley ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cardiovascular Risk ◽  
White Matter ◽  
Cardiovascular Risk Factors ◽  
Gray Matter ◽  
Lipid Synthesis ◽  
Cardiovascular Risks ◽  
Myelin Lipid ◽  
Cortical Gray Matter ◽  
The Brain

Cardiovascular risk factors such as dyslipidemia and hypertension increase the risk for white matter pathology and cognitive decline. We hypothesize that white matter levels of N-acetylaspartate (NAA), a chemical involved in the metabolic pathway for myelin lipid synthesis, could serve as a biomarker that tracks the influence of cardiovascular risk factors on white matter prior to emergence of clinical changes. To test this, we measured levels of NAA across white matter and gray matter in the brain using echo planar spectroscopic imaging (EPSI) in 163 individuals and examined the relationship of regional NAA levels and cardiovascular risk factors as indexed by the Framingham Cardiovascular Risk Score (FCVRS). NAA was strongly and negatively correlated with FCVRS across the brain, but, after accounting for age and sex, the association was found primarily in white matter regions, with additional effects found in the thalamus, hippocampus, and cingulate gyrus. FCVRS was also negatively correlated with creatine levels, again primarily in white matter. The results suggest that cardiovascular risks are related to neurochemistry with a predominantly white matter pattern and some subcortical and cortical gray matter involvement. NAA mapping of the brain may provide early surveillance for the potential subclinical impact of cardiovascular and metabolic risk factors on the brain.

scholarly journals Toward MRI-based whole-brain health assessment: The brain atrophy and lesion index (BALI)

2018 ◽  
Vol 1 (1) ◽  
pp. 55-63 ◽  
Author(s):  
Lukas A. Grajauskas ◽  
Hui Guo ◽  
Ryan C.N. D'Arcy ◽  
Xiaowei Song
Keyword(s):  
Brain Atrophy ◽  
Health Assessment ◽  
Brain Health ◽  
Whole Brain ◽  
The Brain ◽  
Lesion Index

‘Alzheimer-like’ pathology in a murine model of arterial hypertension

2011 ◽  
Vol 39 (4) ◽  
pp. 939-944 ◽  
Author(s):  
Daniela Carnevale ◽  
Giuseppe Lembo
Keyword(s):  
Risk Factors ◽  
Cardiovascular Risk ◽  
Cardiovascular Risk Factors ◽  
Strong Association ◽  
Epidemiological Studies ◽  
Brain Parenchyma ◽  
Murine Models ◽  
Ad Alzheimer’S Disease ◽  
The Brain

Genetic AD (Alzheimer's disease) accounts for only few AD cases and is almost exclusively associated with increased amyloid production in the brain. Instead, most patients are affected with the sporadic form of AD and typically have altered clearance mechanisms. The identification of factors that influence the onset and progression of sporadic AD is a key step towards understanding its mechanism(s) and developing successful therapies. An increasing number of epidemiological studies describe a strong association between AD and cardiovascular risk factors, particularly hypertension, that exerts detrimental effects on the cerebral circulation, favouring chronic brain hypoperfusion. However, a clear demonstration of a pathophysiological link between cardiovascular risk factors and AD aetiology is still missing. To increase our knowledge of the mechanisms involved in the brain's response to hypertension and their possible role in promoting amyloid deposition in the brain, we have performed and investigated in depth different murine models of hypertension, induced either pharmacologically or mechanically, leading in the long term to plaque formation in the brain parenchyma and around blood vessels. In the present paper, we review the major findings in this particular experimental setting that allow us to study the pathogenetic mechanisms of sporadic AD triggered by vascular risk factors.

P1255DIASTOLIC BLOOD PRESSURE IS ASSOCIATED WITH BRAIN ATROPHY IN HEMODIALYSIS PATIENTS: A SINGLE CENTER CASE CONTROL STUDY

2020 ◽  
Vol 35 (Supplement_3) ◽  
Author(s):  
Keren Cohen-Hagai ◽  
Feda Fanadka ◽  
Tania Grumberg ◽  
Guy Topaz ◽  
Naomi Nacasch ◽  
...  
Keyword(s):  
Risk Factors ◽  
Blood Pressure ◽  
Cardiovascular Risk ◽  
Cardiovascular Risk Factors ◽  
Brain Atrophy ◽  
Hemodialysis Patients ◽  
Cerebral Hypoperfusion ◽  
Common Finding ◽  
Control Group ◽  
Chronic Hypertension

Abstract Background and Aims Brain atrophy (BA) is a common finding in neuroimaging of hemodialysis (HD) patients, representing a parenchymal cerebral damage. Likely contributing factors to BA are age, chronic hypertension, diabetes mellitus and other cardiovascular risk factors of atherosclerosis that are also common among HD patients. BA may also occur due to focal ischemia and hypoperfusion during HD. However, data on optimal blood pressure (BP) in these patients are limited. The goal of this study was to determine whether the prevalence and severity of BA would be higher among HD patients with lower BP. Method A blinded neuroradiologist graded BA of all HD patients who underwent brain non-contrast computerized tomography (CT) from 2015 to 2017 in our institution. Age-and sex-matched patients with normal kidney function who underwent brain CT during the same period and technique served as the control group Results A total of 280 patients were included in this retrospective study, with average BP of 140/70 mmHg among HD patients and 142/75 mmHg in the control group. BA was more common in dialysis patients and its severity increased with age and traditional cardiovascular risk factors. We observed a significant negative correlation between diastolic BP (DBP) at dialysis initiation and BA. Average DBP decreased with increasing severity of BA. These findings were observed in both HD and non-CKD patients. Conclusion Brain atrophy was associated with lower DBP, which may induce cerebral hypoperfusion and ischemia. This finding should discourage over-treatment of hypertension in hemodialysis patients.

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