O3-07-03: A LINK BETWEEN COGNITIVE FUNCTION AND PHYSICAL ACTIVITY: THE IMPACT OF AEROBIC-STRENGTH EXERCISE IN SENIORS WITH MILD COGNITIVE IMPAIRMENT AND/OR IMPAIRED GLUCOSE METABOLISM

Background: While the lockdown strategies taken by many countries effectively limited the spread of COVID-19, those were thought to have a negative impact on older people. This study aimed to investigate the impact of lockdown on cognitive function and neuropsychiatric symptoms over a 1-year follow-up period in patients with mild cognitive impairment (MCI), Alzheimer's disease (AD) and dementia with Lewy bodies (DLB).Methods: We enrolled consecutive patients with MCI, probable AD or DLB who were receiving outpatient memory care before the COVID-19 pandemic and followed-up with them after 1 year by face-to-face during the COVID-19 pandemic to assess changes in physical activity, social contact, cognitive function and neuropsychiatric symptoms (NPS).Results: Total 105 probable AD, 50 MCI and 22 probable DLB patients were included and completed the 1-year follow-up between October 31 and November 30, 2020. Among the respondents, 42% of MCI, 54.3% of AD and 72.7% of DLB patients had a decline in MMSE scores and 54.4% of DLB patients had worsening Neuropsychiatric inventory (NPI) scores. Patients with DLB showed a more rapid decline of MMSE than those with AD. Diminished physical activity and social contact might have hastened the deterioration of cognition and the worsening of NPS.Conclusion: Social isolation and physical inactivity even after strict lockdown for at least 6 months were correlated with accelerated decline of cognitive function and NPS in patients with AD and DLB.

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Multi-Component Intervention Program on Habitual Physical Activity Parameters and Cognitive Function in Patients with Mild Cognitive Impairment: A Randomized Controlled Trial

International Journal of Environmental Research and Public Health ◽

10.3390/ijerph18126240 ◽

2021 ◽

Vol 18 (12) ◽

pp. 6240

Author(s):

Min-Ki Jeong ◽

Kyung-Won Park ◽

Je-Kwang Ryu ◽

Gwon-Min Kim ◽

Hyun-Hun Jung ◽

...

Keyword(s):

Physical Activity ◽

Cognitive Impairment ◽

Mild Cognitive Impairment ◽

Cognitive Function ◽

Intervention Program ◽

Vigorous Physical Activity ◽

Cognitive Intervention ◽

Habitual Physical Activity ◽

Disease Assessment ◽

Digit Symbol Substitution Test

Age-related dementia refers to a state in which someone experiences multiple cognitive function impairment due to degenerative brain disease, and which causes difficulties in their daily life or social life. Dementia is the most common and serious obstacle in later life. Early intervention in the case of patients who are in the mild cognitive impairment (MCI) stage among the high-risk group can maintain and improve their cognitive function. The purpose of the current trial is aimed at investigating the association between a multi-component (exercise with cognitive) intervention program and habitual physical activity parameters on cognitive functions in MCI patients. Neuropsychological cognitive and depression assessments were performed by neuropsychologists according to normalized methods, including the Korean mini-mental State examination (K-MMSE) and modified Alzheimer’s disease assessment scale-cognitive subscale (ADAS-Cog) and cognitive assessment tool (attention, processing speed), and the Korean version of the geriatric depression scale (SGDS-K), both at baseline and at a 12 weeks follow-up. The 12-week multi-component intervention improved cognitive function and habitual physical activity parameters in patients with MCI relative to controls. A multi-component intervention program for patients with MCI is considered to be an effective method of dementia prevention by improving global (ADAS-Cog) and frontal (trail-making test, digit symbol substitution test) cognition and habitual physical activity parameters such as moderate to vigorous physical activity and step count. In addition, it is important to encourage habitual physical activities to ensure that exercise intervention strategies are carried out at the duration and intensity required for improving physical and cognitive wellbeing and obtaining health benefits.

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The impact of physical activity on blood inflammatory cytokines and neuroprotective factors in individuals with mild cognitive impairment: a systematic review and meta-analysis of randomized-controlled trials

Aging Clinical and Experimental Research ◽

10.1007/s40520-021-02069-6 ◽

2022 ◽

Author(s):

Chuyi Ma ◽

Miaoran Lin ◽

Jiahui Gao ◽

Shurui Xu ◽

Li Huang ◽

...

Keyword(s):

Physical Activity ◽

Systematic Review ◽

Cognitive Impairment ◽

Mild Cognitive Impairment ◽

Randomized Controlled Trials ◽

Inflammatory Cytokines ◽

Meta Analysis ◽

Controlled Trials ◽

Randomized Controlled ◽

The Impact

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Effects of Physical Activity Program on cognitive function and sleep quality in elderly with mild cognitive impairment: A randomized controlled trial

Perspectives In Psychiatric Care ◽

10.1111/ppc.12324 ◽

2018 ◽

Vol 55 (3) ◽

pp. 401-408 ◽

Cited By ~ 4

Author(s):

Kerime Bademli ◽

Neslihan Lok ◽

Muammer Canbaz ◽

Sefa Lok

Keyword(s):

Physical Activity ◽

Randomized Controlled Trial ◽

Cognitive Impairment ◽

Mild Cognitive Impairment ◽

Cognitive Function ◽

Sleep Quality ◽

Controlled Trial ◽

Physical Activity Program ◽

Randomized Controlled ◽

Activity Program

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Physical Activity and Cognitive Function in Mild Cognitive Impairment

ASN NEURO ◽

10.1177/1759091419901182 ◽

2020 ◽

Vol 12 ◽

pp. 175909141990118

Author(s):

Ya-Ting Chang

Keyword(s):

Physical Activity ◽

Cognitive Impairment ◽

Mild Cognitive Impairment ◽

Cognitive Function

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A Cross Sectional Analysis of Physical Activity Engagement in Adults with Mild Cognitive Impairment

10.21203/rs.3.rs-228490/v1 ◽

2021 ◽

Author(s):

Leona Connolly ◽

Joanna McHugh Power ◽

Brian Lawlor

Keyword(s):

Physical Activity ◽

Cognitive Impairment ◽

Mild Cognitive Impairment ◽

Cognitive Function ◽

Handgrip Strength ◽

Secondary Data ◽

Cross Sectional Study ◽

Subjective Measures ◽

Cross Sectional ◽

Activity Engagement

Abstract Background To address the paucity of literature regarding the relationship between mild cognitive impairment and physical activity engagement, this study aimed to understand the relative contribution of cognitive, demographic, physical and psychological variables related to physical activity engagement in individuals with mild cognitive impairment. Method This was a descriptive, cross – sectional study of secondary data from 62 participants with MCI (mean age 70.53, SD = 6.34), 53.2% female, median MoCA 23 (IQR: 20, 24)) from the NeuroExercise study, a 12 – month PA intervention on the outcome of cognitive function. The independent variable of interest was global cognitive function. Age, gender, years of education, number of medications, handgrip strength, depression, and quality of life were treated as covariates. The dependent variable was PA engagement in minutes per week, using the LAPAQ physical activity questionnaire and the Actigraph triaxial accelerometer device. Results Hierarchical regression analyses showed no significant effect of cognitive function on physical activity engagement after controlling for the effects of covariates. Physical activity engagement was low relative to global physical activity guidelines ((M = 111.38, SD = 94.29) Actigraph ( t (51) = -2.95, p < .005) and the LAPAQ (M = 51.71, SD = 22.80), t (61) = -33.94, p = < .001)). A Bland- Altman measure of agreement demonstrated that objective and subjective measures of physical activity were not equivalent. Conclusions This sample of adults with MCI were not sufficiently physically active. Further, there was substantial variability between objective and subjective measures of physical activity engagement. Objective measurement of PA data may be more reliable for adults with mild cognitive impairment.

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Accelerometer Physical Activity is Associated with Greater Gray Matter Volumes in Older Adults Without Dementia or Mild Cognitive Impairment

The Journals of Gerontology Series B ◽

10.1093/geronb/gby010 ◽

2018 ◽

Vol 74 (7) ◽

pp. 1142-1151 ◽

Cited By ~ 13

Author(s):

Shannon Halloway ◽

Konstantinos Arfanakis ◽

JoEllen Wilbur ◽

Michael E Schoeny ◽

Susan J Pressler

Keyword(s):

Physical Activity ◽

Older Adults ◽

Cognitive Impairment ◽

Mild Cognitive Impairment ◽

Cognitive Function ◽

Gray Matter ◽

Cross Sectional ◽

Gray Matter Atrophy ◽

Age Related ◽

Gray Matter Volumes

Abstract Objectives Physical activity (PA) is a modifiable health behavior that can protect against age-related gray matter atrophy and cognitive dysfunction. Current studies of PA and gray matter failed to utilize device measures of PA and do not focus on adults >80 years. Thus, the purpose of this secondary analysis was to examine cross-sectional associations between accelerometer lifestyle PA and (a) gray matter volumes and (b) cognitive function, controlling for demographics, and health status. Method Participants were 262 older adults without dementia or mild cognitive impairment from Rush Memory and Aging Project, an epidemiological cohort study. Participants wore an accelerometer to assess total daily lifestyle PA, and completed anatomical magnetic resonance imaging to assess gray matter volumes and a neurocognitive test battery to assess cognitive function. Results Multivariate linear regression indicated that higher levels of total daily lifestyle PA was significantly related to larger gray matter volumes, F(2, 215) = 3.61, p = .027, including subcortical gray matter (β = 0.17, p = .007) and total gray matter (β = 0.11, p = .049), with no significant associations between lifestyle PA and cognitive function. Discussion These findings may inform future lifestyle PA interventions in order to attenuate age-related gray matter atrophy.

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