A thalamo-preoptic pathway promoting social touch

Social touch is an important form of communication, it is still unknown how it is processed. Here, we discovered a functional role for a neuronal pathway projecting from the posterior intralaminar thalamic nucleus (PIL) to the medial preoptic area (MPOA) in controlling social contact. Neurons in the PIL and the MPOA were activated by physical contact between female rodents and also by chemogenetic stimulation of PIL neurons. Chemogenetic stimulation of PIL neurons tagged by social contact experience increased direct physical interactions between familiar female rats without affecting other forms of social behavior. Furthermore, selective stimulation of the PIL-MPOA pathway, and the local activation of PIL terminals within the MPOA, elevated direct social contact between the animals suggesting the role of pathway-specific activated cell assemblies. Neurons projecting from the PIL to the MPOA contain the neuropeptide parathyroid hormone 2 (PTH2). The expression of the peptide was induced by social housing, the presence of PTH2 receptor was identified in MPOA neurons, and local injection of PTH2 increased the firing rate of identified preoptic area GABAergic neurons via the PTH2 receptor suggesting that PTH2 acts as a neurotransmitter in the PIL-MPOA pathway. We also found a homologous PIL to MPOA neuronal pathway in the human brain. Altogether, we discovered a direct thalamo-preoptic pathway, which bypasses the cerebral cortex and controls social touch. This pathway originates in neurons expressing PTH2, a neuropeptide recently shown in fish to respond to the social environment. These observations provide evidence for common evolutionary-conserved PTH2-containing social-touch specific engram circuits.

Social Interaction: Communicative Approach

The article focuses on the study of requirements for communication in the social sphere and justification of their specificity in comparison with other types of verbal interaction. The relevance of the stated problem is determined by the significant influence of social communications on society and the dependence of public safety on the effectiveness of social interaction. The study aimed at identifying the types of violations of commonly known maxims in the social sphere and substantiating the specificity of requirements for social communicative interaction. Two main methods were used in the research: projecting and modeling. The well-known communication maxims were divided into two groups. The first group contains those that define the requirements for organizing the content of the message and are aimed at ensuring the fullness of its perception by the addressees. The second group includes maxims, which establish requirements for the moral climate of communication and the implementation of the principle of politeness. The data of interviews given by representatives of governmental bodies to journalists of certain TV channels and blogs, as well as the analysis of Internet news videos revealed the types of violations of the well-known maxims of communication in the social domain. The main ones are: ignoring the maxims of the second group in interviews and non-compliance with the maxims of the first group in news programs. It has been proved that the well-known maxims of communication need to be revised taking into account the conditions of social contact discourse. The specificity of maxims in social communicative interaction was substantiated.

Technological Solutions for Helping Adaptive Responding of Children with Severe to Profound Developmental Disabilities

This article provides the reader with a literature overview of the newest empirical evidences available on the use of assistive technology-based programs for teaching and improving adaptive responding of children with severe to profound developmental disabilities. Four main categories of studies were selected, regarding (a) the technology for promoting independent access to positive stimulation, (b) the combination between microswitch and VOCA aimed at asking for social contact with a caregiver, (c) the cluster technology for increasing an adaptive response, and simultaneously reducing a challenging behavior, (d) the technology for requesting and choosing desired item or the access to the literacy. Overall, 26 studies were reviewed, and 75 participants were involved. The outcomes were largely positive, although few failures occurred. Psychological and Rehabilitative implications of the findings for both research and clinical practices were critically discussed

Window to the Destination: Tourists’ Local Experience via “Online Experiences” on Airbnb Amid the Pandemic

This study aims to explore the composition of virtual guided tour experience on Airbnb and to develop a formation process of virtual guided tour experience. A case study based on the qualitative analysis was conducted with a dataset of online reviews towards an Online Experience in Beijing, China. A three-stage process of virtual guided tour experience was concluded, including experience encounter, experience evaluation, and behavioral intention. Experience encounter describes the experience composition from four dimensions: interpretation quality, host credibility, tourist-host social contact, and peer interaction; Experience evaluation is involved with benefits mainly gained from the enhanced understanding of local culture and the satisfaction attributed by the sense of telepresence; Further, behavioral intention covers both online and offline willingness to recommend or repurchase the virtual tour, or visit the destination in person after the pandemic. Theoretical and practical implications in navigating tourism recovery were discussed.

University Operations During a Pandemic: A Flexible Decision Analysis Toolkit

Modeling infection spread during pandemics is not new, with models using past data to tune simulation parameters for predictions. These help in understanding of the healthcare burden posed by a pandemic and responding accordingly. However, the problem of how college/university campuses should function during a pandemic is new for the following reasons: (i) social contact in colleges are structured and can be engineered for chosen objectives; (ii) the last pandemic to cause such societal disruption was more than 100 years ago, when higher education was not a critical part of society; (iii) not much was known about causes of pandemics, and hence effective ways of safe operations were not known; and (iv) today with distance learning, remote operation of an academic institution is possible. As one of the first to address this problem, our approach is unique in presenting a flexible simulation system, containing a suite of model libraries, one for each major component. The system integrates agent-based modeling and the stochastic network approach, and models the interactions among individual entities (e.g., students, instructors, classrooms, residences) in great detail. For each decision to be made, the system can be used to predict the impact of various choices, and thus enables the administrator to make informed decisions. Although current approaches are good for infection modeling, they lack accuracy in social contact modeling. Our agent-based modeling approach, combined with ideas from Network Science, presents a novel approach to contact modeling. A detailed case study of the University of Minnesota’s Sunrise Plan is presented. For each decision made, its impact was assessed, and results were used to get a measure of confidence. We believe that this flexible tool can be a valuable asset for various kinds of organizations to assess their infection risks in pandemic-time operations, including middle and high schools, factories, warehouses, and small/medium-sized businesses.

Impact of COVID-19 Pandemic on (Health) Care Situation of People with Parkinson’s Disease in Germany (Care4PD)

The Care4PD study examined the impact of the COVID-19 pandemic on the care situation of people (PwP) with Parkinson’s disease in Germany. A comprehensive, nationwide, anonymous questionnaire for PwP was distributed by the members’ journal of the German Parkinson’s Disease Association and in several PD specialized in- and outpatient institutions. PwP subjectively evaluated their general care situation and individual impairments during the pandemic. We analyzed 1269 eligible out of 1437 returned questionnaires (88.3%) and compared PwP with (p-LTC) and without (np-LTC) professional long-term care. Both groups rated the general pandemic-related consequences as being rather mild to moderate (e.g., worsening of symptom or concerns). However, familial/social contact restrictions were indicated as most compromising, whereas access to outpatient professional health care providers was less affected. PwP with professional LTC reported more impairment than those without. COVID-19 vaccination rates and acceptance were generally high (p-LTC: 64.3%, np-LTC: 52.3%) at the time of the study, but realization of sanitary measures—especially wearing masks as a patient during care sessions—still needs to be improved. Technical options for telemedicine were principally available but only rarely used. Altogether, during the COVID-19 pandemic, PwP in Germany seemed to have a relatively stable health care access, at least in outpatient settings, while mainly social isolation compromised them. The p-LTC group was more impaired in everyday live compared with the np-LTC group.