scholarly journals P3-497: VARIATIONS IN REFERRALS, ASSESSMENTS AND TREATMENT OF ALZHEIMER'S DISEASE FOR AFRICAN AMERICANS IN THE DEEP SOUTH

2019 ◽  
Vol 15 ◽  
pp. P1159-P1159
Author(s):  
Charles F. Murchison ◽  
Richard E. Kennedy ◽  
Jonathan McConathy ◽  
Erik D. Roberson
2021 ◽  
Vol 5 (Supplement_1) ◽  
pp. 100-100
Author(s):  
Maria Pisu ◽  
David Geldmacher

Abstract Residents of the US Deep South (Alabama, Georgia, Louisiana, Mississippi, and South Carolina) have a 20–30% higher risk of developing Alzheimer’s disease or related dementia (ADRD). Moreover, >20% of African Americans, who are at higher ADRD risk than whites, live in this region. Therefore, one important goals of the Deep South Alzheimer’s Disease Center (DS-ADC) of the University of Alabama at Birmingham is to spearhead research to address these disparities. This panel presents current DS-ADC research, with two presentations focusing on the local patient population and the last two on the Deep South population compared to the rest of the nation. Addressing the challenge of recruiting representative samples in clinical research, the first paper is part of a research program to understand difference that may exist between African American and white research participants. The second paper examines patients with multiple conditions, in particular dementia and cancer, showing a marked disadvantage in cognition outcomes for African Americans. The next two papers take a broader perspective to better understand the population of older adults with ADRD in the Deep South and in the rest of the US. The third paper examines socioeconomic and medical contexts of African American and white older Medicare beneficiaries with ADRD, and the fourth paper examines differences in utilization of specialists, ADRD drugs, and hospitalizations in the two regions taking these contexts into account. The discussant will close the session by placing these studies in the larger context of the disparities research at the DS-ADC.


2021 ◽  
pp. 1-6
Author(s):  
Dianxu Ren ◽  
Oscar L. Lopez ◽  
Jennifer H. Lingler ◽  
Yvette Conley

We examined the association between APOE ɛ2/ɛ4 with incident Alzheimer’s disease (AD) and mild cognitive impairment (MCI) among African Americans using the national dataset from the National Alzheimer’s Coordinating Center (NACC) from 2005 to September 2019. Compared to ɛ3/ɛ3 carriers, ɛ2/ɛ4 carriers exhibited a similar risk of incident AD (adjusted hazard ratio [aHR] = 0.85, 95% CI [0.39, 1.84]) among the AD cohort and similar risk of incident MCI (aHR = 0.88, 95% CI [0.51, 1.50]) among the MCI cohort. Our findings suggest that, unlike the increased risk of AD and MCI in non-Latino whites, APOE ɛ2/ɛ4 genotype is not associated with the incidence of AD and MCI among African Americans.


2015 ◽  
Vol 11 (7S_Part_8) ◽  
pp. P361-P362
Author(s):  
Aurelie Nsongo ◽  
Minerva M. Carrasquillo ◽  
Imelda Barber ◽  
Thuy Nguyen ◽  
Li Ma ◽  
...  

2020 ◽  
Vol 77 (2) ◽  
pp. 843-853
Author(s):  
Antoine R. Trammell ◽  
Darius J. McDaniel ◽  
Malik Obideen ◽  
Maureen Okafor ◽  
Tiffany L. Thomas ◽  
...  

Background: African Americans (AA) have a higher Alzheimer’s disease (AD) prevalence and report more perceived stress than White Americans. The biological basis of the stress-AD link is unclear. This study investigates the connection between stress and AD biomarkers in a biracial cohort. Objective: Establish biomarker evidence for the observed association between stress and AD, especially in AA. Methods: A cross-sectional study (n = 364, 41.8% AA) administering cognitive tests and the perceived stress scale (PSS) questionnaire. A subset (n = 309) provided cerebrospinal fluid for measurement of Aβ42, Tau, Ptau, Tau/Aβ42 (TAR), and Ptau/Aβ42 (PTAR). Multivariate linear regression, including factors that confound racial differences in AD, was performed. Results: Higher PSS scores were associated with higher Ptau (β= 0.43, p = 0.01) and PTAR (β= 0.005, p = 0.03) in AA with impaired cognition (mild cognitive impairment). Conclusion: Higher PSS scores were associated with Tau-related AD biomarker indices in AA/MCI, suggesting a potential biological connection for stress with AD and its racial disparity.


2006 ◽  
Vol 14 (7S_Part_6) ◽  
pp. P339-P339
Author(s):  
Olivia J. Conway ◽  
Minerva M. Carrasquillo ◽  
Jenny M. Bredenberg ◽  
Joseph S. Reddy ◽  
Curtis S. Younkin ◽  
...  

2006 ◽  
Vol 14 (7S_Part_20) ◽  
pp. P1077-P1078
Author(s):  
Grace Byfield ◽  
Takiyah Starks ◽  
Michael L. Cuccaro ◽  
Larry D. Adams ◽  
Patrice L. Whitehead ◽  
...  

2016 ◽  
Vol 12 ◽  
pp. P639-P639
Author(s):  
Aurelie Nsongo ◽  
Minerva M. Carrasquillo ◽  
Xue Wang ◽  
Jeremy D. Burgess ◽  
Thuy Nguyen ◽  
...  

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