scholarly journals P4-025: CHANGE IN VERBAL LEARNING TEST PERFORMANCE STRATIFIED BY BASELINE FLORBETAPIR PET STATUS OVER A SIX-MONTH INTERVAL IN THE ADNI-GO/ADNI2 DATASETS

2019 ◽  
Vol 15 ◽  
pp. P1283-P1284
Author(s):  
John Alam
2003 ◽  
Vol 4 (2) ◽  
pp. 155-167 ◽  
Author(s):  
Karleigh Jayne Kwapil ◽  
Gina Geffen ◽  
Ken McFarland ◽  
Veronica Eileen DeMonte

AbstractThe present study aimed to determine whether including a sensitive test of immediate and delayed recall would improve the diagnostic validity of the Rapid Screen of Concussion (RSC) in mild Traumatic Brain Injury (mTBI) versus orthopaedic clinical samples. Two studies were undertaken. In Study 1, the performance of 156 mTBI and 145 orthopaedic participants was analysed to identify the number of individuals who performed at ceiling on the verbal memory subtest of the RSC, as this test required immediate and delayed recall of only five words. A second aim was to determine the sensitivity and specificity levels of the RSC. Study 2 aimed to examine whether replacement of the verbal memory subtest with the 12-word Hopkins Verbal Learning Test (HVLT) could improve the sensitivity of the RSC in a new sample of 26 mTBI and 30 orthopaedic participants. Both studies showed that orthopaedic participants outperformed mTBI participants on each of the selected measures. Study 1 showed that 14% of mTBI participants performed at ceiling on the immediate and 21.2% on delayed recall test. Performance on the original battery yielded a sensitivity of 82%, specificity of 80% and overall correct classification of 81.5% participants. In Study 2, inclusion of the HVLT improved sensitivity to a level of 88.5%, decreased specificity to a level of 70% and resulted in an overall classification rate of 80%. It was concluded that although inclusion of the five-word subtest in the RSC can successfully distinguish concussed from non-concussed individuals, use of the HVLT in this protocol yields a more sensitive measure of subtle cognitive deficits following mTBI.


2007 ◽  
Vol 14 (1) ◽  
pp. 71-80 ◽  
Author(s):  
WIM VAN DER ELST ◽  
MARTIN P.J. VAN BOXTEL ◽  
GERARD J.P. VAN BREUKELEN ◽  
JELLE JOLLES

Serial neuropsychological assessment is often conducted to monitor changes in the cognitive abilities of individuals over time. Because practice effects occur and the reliability of test scores is less than perfect, it is difficult to judge whether varying test results should be attributed to chance trends or to real changes in underlying cognitive abilities. In a large sample of adults (age range, 49–81 years), we evaluated the influence of age, gender, and education on test–retest changes in performance after 3 years on Rey's Verbal Learning Test (VLT), the Stroop Color-Word Test (SCWT), and the Letter Digit Substitution Test (LDST). A new statistical method was applied to assess the significance of changes in test performance (i.e., the regression-based change method). The results showed that test–retest changes differed as a function of age for the VLT Total recall 1–3, VLT Total recall 1–5, VLT Delayed recall, and LDST measures. An age × gender interaction was found for the SCWT Interference change score, suggesting that the age-related decline in executive functioning after 3 years was more pronounced for males than for females. A normative change table with appropriate corrections for the relevant independent variables was established. (JINS, 2008,14, 71–80.)


1964 ◽  
Vol 110 (464) ◽  
pp. 80-83 ◽  
Author(s):  
Bernard Isaacs ◽  
Frank A. Walkey

In studies of the incidence and prognosis of disease in the elderly it is valuable to have an objective measure of the patient's mental state. In a previous paper (Isaacs, 1962) a paired-associate verbal learning test devised by Inglis (1959) was applied to a group of 50 normal and 100 hospitalized old people, and was found to give useful information on the relationship between test performance and such factors as incontinence of urine and prognosis for rehabilitation. In the present study a simplified version of this test was performed on a larger number of elderly hospital patients. The test proved valuable in determining the characteristics of patients with varying degrees of mental impairment.


2003 ◽  
Vol 61 (4) ◽  
pp. 920-924 ◽  
Author(s):  
Paulo Mattos ◽  
Valéria Lino ◽  
Luciana Rizo ◽  
Ângela Alfano ◽  
Cátia Araújo ◽  
...  

In order to compare the use of a structured self-report questionnaire with direct questioning about memory problems, 71 healthy and independent aged individuals (63 women) from the community without risk factors for cognitive deficits were objectively asked about subjective memory complaints (SMC), given the Memory Complaint Questionnaire (MAC-Q) and then submitted to the Rey Auditory Verbal Learning Test (RAVLT). SMC positively correlated with higher scores on MAC-Q, although a significant percentage of the sample had SMC and lower scores on MAC-Q and also no SMC and higher scores on MAC-Q. Performance on RAVLT was significantly worse (p<0.05) for the group presenting SMC but not for the group with higher scores on the MAC-Q. We conclude that direct questioning maybe more clinically significant than a self report questionnaire, at least for elderly persons from the community without risk factors for cognitive decline or depression.


2002 ◽  
Vol 16 (3) ◽  
pp. 290-299 ◽  
Author(s):  
Suzanne Barker-Collo ◽  
Anna Clarkson ◽  
Ainsleigh Cribb ◽  
Mary Grogan

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