Home-based primary care is on the rise for several reasons: an aging population for which office-based care is less convenient, favorable changes in Medicare fee-for-service reimbursement, and a greater recognition that the care of sick homebound adults may be better done in their home. Home care practices can care for homebound patients with multiple comorbidities more efficiently, with lower costs and equivalent or superior outcomes. Home care is invaluable for individuals who may not be able to travel easily to a clinician’s office. Integrative Medicine may provide helpful treatment modalities for individuals being cared for at home—in particular, complementary treatments for common conditions such as chronic pain, falls, depression, anxiety, and insomnia. The home has also become an important educational setting in which learners can readily acquire the knowledge, skills, and attitudes that are essential in providing optimal care for complex, frail patients.