The Role of HPV Testing in Cytologic Diagnosis of Atypical Glandular Cells

2020 ◽  
Vol 9 (6) ◽  
pp. S27
Author(s):  
Lan Zheng ◽  
Howard Wu
Keyword(s):  
Hpv Testing ◽  
Cytologic Diagnosis ◽  
Glandular Cells ◽  
Atypical Glandular Cells

scholarly journals High-risk HPV testing in the management of atypical glandular cells: A systematic review and meta-analysis

2015 ◽  
Vol 138 (2) ◽  
pp. 303-310 ◽  
Author(s):  
Freija Verdoodt ◽  
Xuezhi Jiang ◽  
Mark Williams ◽  
Peter F. Schnatz ◽  
Marc Arbyn
Keyword(s):  
Systematic Review ◽  
High Risk ◽  
Meta Analysis ◽  
Hpv Testing ◽  
Glandular Cells ◽  
Atypical Glandular Cells ◽  
High Risk Hpv

scholarly journals Human Papillomavirus Testing and Reporting Rates in 2012: Results of a College of American Pathologists National Survey

2014 ◽  
Vol 139 (6) ◽  
pp. 757-761 ◽  
Author(s):  
Chengquan Zhao ◽  
Ann T. Moriarty ◽  
Mohiedean Ghofrani ◽  
Mujtaba Husain ◽  
Rosemary H. Tambouret ◽  
...  
Keyword(s):  
Human Papillomavirus ◽  
Proficiency Testing ◽  
Hpv Testing ◽  
Papanicolaou Test ◽  
Squamous Cells ◽  
Human Papillomavirus Testing ◽  
Glandular Cells ◽  
Atypical Glandular Cells ◽  
Reflex Testing ◽  
Roche Cobas

Context College of American Pathologists (CAP) surveys are used to establish national benchmarks for laboratory parameters. Objective To evaluate changes in laboratory human papillomavirus (HPV) testing patterns in laboratories incorporating HPV testing with Papanicolaou tests in 2012. Design Data were analyzed from the CAP HPV Supplemental Questionnaire distributed to 1771 laboratories participating in either CAP HPV or CAP Papanicolaou proficiency testing in 2013. Results A total of 1022 laboratories (58%) responded. There were more high-risk (HR) HPV tests performed per institution as compared to previous surveys. There were more HPV tests performed within an institution as compared to previous surveys. Hybrid Capture 2 (HC2) remains the most common method (42.4%, 239 of 564); Cervista and cobas methods are used in 37.2% (210 of 564) and 14.9% (84 of 564) of laboratories, respectively. Human papillomavirus testing is offered as a reflex test after a Papanicolaou test result of atypical squamous cells of undetermined significance (ASC-US) in 89.6% of laboratories (476 of 531); as a cotest for women aged 30 years and older in 60.3% (404 of 531); as reflex testing after atypical squamous cells, cannot exclude high-grade squamous intraepithelial lesion (ASC-H) in 42.7% (320 of 531); and as reflex testing after atypical glandular cells (AGC) in 27.3% (145 of 531). The HPV-positive rates for ASC-US and ASC-H were similar in 2012 and 2006. Cervista (49.2%, 88 of 179) and Roche cobas (27.4%, 49 of 179) are the most common methods used for genotyping. Most laboratories use the CAP Human Papillomavirus for Cytology Program for proficiency testing. Conclusions There was an increase in annual volume of HR-HPV testing with a shift toward in-house HR-HPV testing. Genotyping volumes also increased. HC2 and Cervista are most commonly used, with an increasing volume of Roche cobas testing. The most common indication for HPV testing among all laboratories was ASC-US reflex testing, but an increase in HPV cotesting was observed. The data provide an update into persisting and newer trends in HPV testing practices.

Outcomes of Women With Atypical Glandular Cells on Preoperative Cytology and Endometrial Cancer

2014 ◽  
Vol 24 (2) ◽  
pp. 266-271 ◽  
Author(s):  
Michael S. Guy ◽  
Georgina Cheng ◽  
Miriam D. Post ◽  
Monique A. Spillman ◽  
Kian Behbakht ◽  
...  
Keyword(s):  
Endometrial Cancer ◽  
Endometrial Adenocarcinoma ◽  
Statistical Prediction ◽  
Ca 125 ◽  
Cytologic Diagnosis ◽  
Gynecology And Obstetrics ◽  
Occult Metastatic Disease ◽  
Glandular Cells ◽  
Atypical Glandular Cells ◽  
Poor Outcomes

ObjectiveThis study aims to examine the prognostic importance of preoperative cervical cytologic diagnosis with atypical glandular cells (AGC) or malignant cells (MC) as a predictor of poor outcomes in endometrial cancer.Materials and MethodsA total of 563 patients were surgically staged for endometrial adenocarcinoma from 2002 to 2012 at our institution. Of these patients, 106 were included to perform a case-control study (39 patients with AGC or MC and 67 controls). Included patients were not significantly different from excluded patients and were matched for age, race, and body mass index. Outcome variables included presence of extrauterine disease (International Federation of Gynecology and Obstetrics stage ≥II) and high intermediate risk (HIR) disease. Further analysis sought to improve the prediction combining AGC or MC with other factors, such as grade and CA-125 levels. Standard statistical analyses were used.ResultsAmong the patients with AGC or MC, 53.8% had HIR disease compared with 30.3% with normal cervical cytologic diagnosis (odds ratio [OR], 2.68; 95% confidence interval [CI], 1.18–6.09; P = 0.02). Extrauterine disease was found in 43.6% of patients with AGC or MC compared with that of 15.2% in patients with normal cervical cytologic diagnosis (OR, 4.33; 95% CI, 1.72–10.90; P < 0.01). Multivariate analysis confirmed that AGC or MC was an independent predictor of HIR disease (OR, 8.41; 95% CI, 1.34–52.78; P = 0.02) and extrauterine disease (OR, 4.78; 95% CI, 1.26–18.1; P = 0.02). The combination of elevated CA-125 levels with AGC or MC cervical cytologic diagnosis increased the statistical prediction of extrauterine disease (OR, 13.3; 95% CI, 3.1–56.8; P < 0.01) and HIR disease (OR, 5.83; 95% CI, 1.44–23.71; P = 0.02).ConclusionsPatients with AGC or MC on preoperative cervical cytology are at risk for extrauterine and HIR disease. These preoperative findings should warn surgeons of the potential of extrauterine or occult metastatic disease.

Clinical Significance of a Cytologic Diagnosis of Atypical Glandular Cells, Favor Endometrial Origin, in Pap Smears

2006 ◽  
Vol 50 (1) ◽  
pp. 48-54 ◽  
Author(s):  
Reda S. Saad ◽  
Hidehero Takei ◽  
Yulin L. Liu ◽  
Jan F. Silverman ◽  
Jane T. Lipscomb ◽  
...  
Keyword(s):  
Clinical Significance ◽  
Pap Smears ◽  
Cytologic Diagnosis ◽  
Glandular Cells ◽  
Atypical Glandular Cells

Cytologic and histologic review of atypical glandular cells (AGC) detected during cervical cytology screening

2003 ◽  
Vol 13 (4) ◽  
pp. 518-521 ◽  
Author(s):  
C.-J. Jeng ◽  
H.-S. Liang ◽  
T.-Y. Wang ◽  
J. Shen ◽  
Y.-C. Yang ◽  
...  
Keyword(s):  
Pap Smear ◽  
Intraepithelial Neoplasia ◽  
Endometrial Biopsy ◽  
High Grade ◽  
Cytologic Diagnosis ◽  
Histologic Diagnosis ◽  
Pap Smear Screening ◽  
Glandular Cells ◽  
Atypical Glandular Cells ◽  
Underlying Pathology

This article is to determine the clinical significance and underlying pathology among patients with atypical glandular cells (AGC) identified during cervical Papanicolau (Pap) smear screening. AGC slides were searched from 51,412 computerized files of the cytology laboratory of Mackay Memorial Hospital during a 29-month period. The results of clinical evaluations were reviewed and an experienced gynecologic cytopathologist who was not involved in the original cytologic diagnosis and was not aware of the clinical results of the follow-up examinations rechecked all AGC slides. We used the z score to determine whether different results were achieved after the gynecologic cytopathologist rechecked the slides. We further analyzed all slides with different cytologic diagnoses and compared results with the histologic diagnoses. Forty-nine cases were initially identified as AGC. Among these, 29 were reviewed and identified as AGC again, and the result of biopsies revealed that they were all chronic cervicitis, ie, negative for malignancy or premalignancy. The other 20 cases were reviewed and diagnosed as non-AGC. Among the results of cytologic examinations, seven had inflammation, two had atypical squamous cells of undetermined significance (ASC-US), ten had high-grade cervical intraepithelial neoplasia (CIN), and one had adenocarcinoma. The results of histologic diagnosis included eight cases with normal tissue, two with CIN grade 1, eight with high-grade CIN, one with microinvasive squamous cell carcinoma, and one with adenocarcinoma. Histologic results revealed 20.4%1 (10/49) and 50% (10/20) at initial cytologic diagnosis of AGC and expert-reviewed non-AGC, respectively, which were finally at least high-grade CIN. According to the gynecologic cytopathologist's diagnosis, 59.2%1 (29/49) of cases would have eliminated unnecessary histologically diagnostic procedures. In conclusion, clinicians should be careful about the significance of the cytologic diagnosis of AGC, because there may actually be an underlying pathology, which can be identified by a pathologist who is an expert in gynecologic cytopathology. The interobserver variation in diagnosing AGC favors specialized training in gynecologic cytopathology. In addition, prompt diagnostic interventions, including colposcopy, endocervical curettage, and/or endometrial biopsy, should be performed after confirmation of the diagnosis of non-AGC by an experienced gynecologic cytopathologist.

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