Association of High-Risk HPV Strains other than 16 And 18 and Diagnosis of Atypical Glandular Cells: A 5-Year Study with Follow-Up

2021 ◽  
Vol 10 (5) ◽  
pp. S29
Author(s):  
Mariam Ratiani ◽  
Chinelo Onyenekwu ◽  
Abhinav Grover ◽  
Michelle Moh ◽  
Tamara Giorgadze
Keyword(s):  
High Risk ◽  
Glandular Cells ◽  
Atypical Glandular Cells ◽  
High Risk Hpv

scholarly journals High-risk HPV testing in the management of atypical glandular cells: A systematic review and meta-analysis

2015 ◽  
Vol 138 (2) ◽  
pp. 303-310 ◽  
Author(s):  
Freija Verdoodt ◽  
Xuezhi Jiang ◽  
Mark Williams ◽  
Peter F. Schnatz ◽  
Marc Arbyn
Keyword(s):  
Systematic Review ◽  
High Risk ◽  
Meta Analysis ◽  
Hpv Testing ◽  
Glandular Cells ◽  
Atypical Glandular Cells ◽  
High Risk Hpv

Prediction of high-grade cervical disease with human papillomavirus detection in women with glandular and squamous cytologic abnormalities

2006 ◽  
Vol 16 (3) ◽  
pp. 1055-1062 ◽  
Author(s):  
E. R.Z.M. De Oliveira ◽  
S. F.M. Derchain ◽  
L. O.Z. Sarian ◽  
S. H. Rabelo-Santos ◽  
R. C. Gontijo ◽  
...  
Keyword(s):  
Human Papillomavirus ◽  
High Risk ◽  
Pap Smears ◽  
High Grade ◽  
Strongly Correlated ◽  
Cervical Lesions ◽  
Cervical Disease ◽  
Glandular Cells ◽  
Atypical Glandular Cells ◽  
High Risk Hpv

The objective of this study was to assess whether human papillomavirus (HPV) detection with hybrid capture II (HC II) can help predict the presence and the nature, glandular or squamous, of histologic cervical lesions in women referred due to atypical glandular cells (AGC) or high-grade squamous intraepithelial lesion (HSIL). A total of 247 women were included. Referral Pap smears comprised AGC (51 cases), AGC plus HSIL (28 cases), adenocarcinoma in situ (10 cases), and HSIL (158 cases). All patients were tested for high-risk HPV with HC II and had a histologic assessment of their cervix. Histologic analysis showed 38 women with (15.3%) cervicitis, 194 with (75.5%) squamous lesions, and 15 with (9.2%) glandular neoplasia. The overall rate of high-risk HPV detection was 77%. Almost 70% of AGC-HPV–negative patients did not have a pathologically proven cervical neoplasia, whereas 76% of women with AGC-HPV–positive result were diagnosed with a squamous or glandular neoplasia. Most (95%) of the lesions in patients with AGC-HSIL were of squamous nature, and HPV detection did not contribute to their differentiation from glandular lesions. We conclude that in women with AGC, HPV positivity strongly correlated with the presence of glandular or squamous cervical lesion but did not help distinguishing women with squamous from those with glandular neoplasia.

Prevalence of HPV 16/18 genotypes and histopathologic follow-up outcomes in women with negative cytology and positive high-risk HPV test results

2015 ◽  
Vol 4 (5) ◽  
pp. 261-266 ◽  
Author(s):  
Anna Woodard ◽  
R. Marshall Austin ◽  
Zaibo Li ◽  
Joseph Beere ◽  
Chengquan Zhao
Keyword(s):  
High Risk ◽  
Test Results ◽  
Hpv 16 ◽  
Hpv Test ◽  
High Risk Hpv

scholarly journals Immediate histopathologic follow-up of cervista and aptima high-risk HPV assays in women with LSIL cytology

2018 ◽  
Vol 126 (8) ◽  
pp. 525-532 ◽  
Author(s):  
Huina Zhang ◽  
Kavita R. Varma ◽  
Min Han ◽  
Jonee Matsko ◽  
Chengquan Zhao
Keyword(s):  
High Risk ◽  
High Risk Hpv ◽  
Hpv Assays

scholarly journals More focus on atypical glandular cells in cervical screening: Risk of significant abnormalities and low histological follow-up rate

CytoJournal ◽  
2020 ◽  
Vol 17 ◽  
pp. 22
Author(s):  
Pingping Zhong ◽  
Chenghong Yin ◽  
Yulan Jin ◽  
Tianbao Chen ◽  
Yang Zhan ◽  
...  
Keyword(s):  
Statistical Significance ◽  
Cervical Screening ◽  
Close Relation ◽  
Prior History ◽  
Pap Smears ◽  
Chi Square ◽  
Glandular Cells ◽  
Atypical Glandular Cells ◽  
Chi Square Test

Objectives: Atypical glandular cells (AGC) detected by Papanicolaou (Pap) smears are in close relation with adenocarcinoma and precursors detected by histopathology. Yet, sometimes the cytological diagnosis of AGC has been neglected. With increase of adenocarcinoma and precursors, we need more focus on glandular abnormalities. Material and Methods: Clinicopathological data of patients who had AGC on Pap smears between April 2015 and October 2018 and underwent histological follow-up were retrieved from the computerized database of Beijing Obstetrics and Gynecology Hospital, Capital Medical University. Patients with a prior history of cancer were excluded from the study. Statistical analyses were performed using Pearson’s Chi-square test in SPSS software version 23. P < 0.05 (two sided) was considered as statistical significance. Results: Liquid-based cytological examination of the uterine cervix was carried out in 164,080 women. Five hundred and twenty-five women were diagnosed with AGC, 314 with not otherwise specified (AGC-NOS), and 211 with favor neoplastic (AGC-FN). Only 310 cases had histological follow-up, 168 women (168/314, 53.5%) originally with AGC-NOS on Pap smears, and 142 (142/211, 67.3%) with AGC-FN. The median age of histological significant abnormalities was 46.7 years, and 126 women (126/162, 77.8%) were postmenopausal. Sixty-six cases (66/168, 39.3%) of AGC-NOS had significant abnormalities (96/142, 67.6%, AGC-FN). One hundred and sixty-two cases of significant abnormalities included 40 high-grade squamous abnormalities and 122 glandular abnormalities. AGC-FN was more likely to be associated with a clinically significant abnormalities (P < 0.001) compared to AGC-NOS. Conclusions: Patients with AGC on Pap smears are in close relation with significant abnormalities, especially with significant glandular abnormalities on histopathology slices. AGC should be evaluated vigilantly with histological workup, especially if patients are diagnosed with AGC-FN and are aged 41–60 years. We need more focus on AGC.

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