scholarly journals Perturbing dimer interactions and allosteric communication modulates the immunosuppressive activity of human galectin-7

2021 ◽  
pp. 101308
Author(s):  
N. T. Hang Pham ◽  
Myriam Létourneau ◽  
Marlène Fortier ◽  
Gabriel Bégin ◽  
M. Sameer Al-Abdul-Wahid ◽  
...  
Keyword(s):  
Immunosuppressive Activity ◽  
Allosteric Communication

Research on the immunosuppressive activity of ingredients contained in sunscreens

2015 ◽  
Vol 307 (3) ◽  
pp. 211-218 ◽  
Author(s):  
Jihane Frikeche ◽  
Céline Couteau ◽  
Christos Roussakis ◽  
Laurence J. M. Coiffard
Keyword(s):  
Immunosuppressive Activity

Shifts in macrophage (Mφ) surface phenotypes during tumor growth: Association of Mac-2+ and Mac-3+ Mφ with immunosuppressive activity

1987 ◽  
Vol 108 (2) ◽  
pp. 255-268 ◽  
Author(s):  
Ronald E. Garner ◽  
Adrien P. Malick ◽  
Andrew D. Yurochko ◽  
Klaus D. Elgert
Keyword(s):  
Tumor Growth ◽  
Immunosuppressive Activity

Synthesis and Immunosuppressive Activity of Lipophilic Amino Alcohols and Diamines

2008 ◽  
Vol 72 (6) ◽  
pp. 596-598 ◽  
Author(s):  
Elaine F. C. Reis ◽  
Celso O. R. Júnior ◽  
Lívia L. Alves ◽  
Ana Paula Ferreira ◽  
Mauro V. de Almeida
Keyword(s):  
Amino Alcohols ◽  
Immunosuppressive Activity

scholarly journals Immunosuppressive activity of bovine seminal RNase on T-cell proliferation

1990 ◽  
Vol 190 (1) ◽  
pp. 145-148 ◽  
Author(s):  
Maurizio TAMBURRINI ◽  
Giuseppe SCALA ◽  
Cinzia VERDE ◽  
Maria Rosaria RUOCCO ◽  
Augusto PARENTE ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
T Cell ◽  
T Cell Proliferation ◽  
Immunosuppressive Activity

Differences between rats and mice in the immunosuppressive activity of 2-methoxyethanol and 2-methoxyacetic acid

Toxicology ◽  
1992 ◽  
Vol 74 (1) ◽  
pp. 57-67 ◽  
Author(s):  
Ralph J. Smialowicz ◽  
Marie M. Riddle ◽  
Wanda C. Williams ◽  
Carey B. Copeland ◽  
Robert W. Luebke ◽  
...  
Keyword(s):  
Immunosuppressive Activity ◽  
Methoxyacetic Acid ◽  
Rats And Mice

scholarly journals Enzymatic synthesis and immunosuppressive activity of novel desmethylated immunomycins (ascomycins).

1993 ◽  
Vol 46 (9) ◽  
pp. 1397-1405 ◽  
Author(s):  
ALI SHAFIEE ◽  
TOM S. CHEN ◽  
BYRON S. ARISON ◽  
FRANCIS J. DUMONT ◽  
LAWRENCE COLWELL ◽  
...  
Keyword(s):  
Enzymatic Synthesis ◽  
Immunosuppressive Activity

scholarly journals Time-resolved observation of protein allosteric communication

2017 ◽  
Vol 114 (33) ◽  
pp. E6804-E6811 ◽  
Author(s):  
Sebastian Buchenberg ◽  
Florian Sittel ◽  
Gerhard Stock
Keyword(s):  
Pdz Domain ◽  
Dynamic Network ◽  
Structural Heterogeneity ◽  
Nonequilibrium Molecular Dynamics ◽  
Elastic Response ◽  
Dynamical Process ◽  
Biological Regulation ◽  
Time Resolved ◽  
Allosteric Communication ◽  
Time Resolved Infrared Spectroscopy

Allostery represents a fundamental mechanism of biological regulation that is mediated via long-range communication between distant protein sites. Although little is known about the underlying dynamical process, recent time-resolved infrared spectroscopy experiments on a photoswitchable PDZ domain (PDZ2S) have indicated that the allosteric transition occurs on multiple timescales. Here, using extensive nonequilibrium molecular dynamics simulations, a time-dependent picture of the allosteric communication in PDZ2S is developed. The simulations reveal that allostery amounts to the propagation of structural and dynamical changes that are genuinely nonlinear and can occur in a nonlocal fashion. A dynamic network model is constructed that illustrates the hierarchy and exceeding structural heterogeneity of the process. In compelling agreement with experiment, three physically distinct phases of the time evolution are identified, describing elastic response (≲0.1 ns), inelastic reorganization (∼100 ns), and structural relaxation (≳1μs). Issues such as the similarity to downhill folding as well as the interpretation of allosteric pathways are discussed.

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