Role of reflex gain and reflex delay in spinal stability—A dynamic simulation

2007 ◽  
Vol 40 (8) ◽  
pp. 1762-1767 ◽  
Author(s):  
Timothy C. Franklin ◽  
Kevin P. Granata
Keyword(s):  
Dynamic Simulation ◽  
Spinal Stability ◽  
Reflex Gain

From Lock-In to Transformation: A Path-Centric Theory of Emerging Technology an Organizing

2021 ◽  
Author(s):  
Brian T. Pentland ◽  
Youngjin Yoo ◽  
Jan Recker ◽  
Inkyu Kim
Keyword(s):  
Drug Discovery ◽  
Dynamic Simulation ◽  
Emerging Technologies ◽  
Emerging Technology ◽  
Basic Question ◽  
Transformative Change ◽  
Pharmaceutical Drug ◽  
Wide Range ◽  
Lock In

We offer a path-centric theory of emerging technology and organizing that addresses a basic question. When does emerging technology lead to transformative change? A path-centric perspective on technology focuses on the patterns of actions afforded by technology in use. We identify performing and patterning as self-reinforcing mechanisms that shape patterns of action in the domain of emerging technology and organizing. We use a dynamic simulation to show that performing and patterning can lead to a wide range of trajectories, from lock-in to transformation, depending on how emerging technology in use influences the pattern of action. When emerging technologies afford new actions that can be flexibly recombined to generate new paths, decisive transformative effects are more likely. By themselves, new affordances are not likely to generate transformation. We illustrate this theory with examples from the practice of pharmaceutical drug discovery. The path-centric perspective offers a new way to think about generativity and the role of affordances in organizing.

The Role of the Lumbar Facet Joints in Spinal Stability

Spine ◽  
1994 ◽  
Vol 19 (23) ◽  
pp. 2667-2670 ◽  
Author(s):  
Thomas R. Haher ◽  
Michael OʼBrien ◽  
Joseph W. Dryer ◽  
Robert Nucci ◽  
Richard Zipnick ◽  
...  
Keyword(s):  
Spinal Stability ◽  
Facet Joints ◽  
Lumbar Facet ◽  
Lumbar Facet Joints

scholarly journals The role of the facet capsular ligament in providing spinal stability

2018 ◽  
Vol 21 (13) ◽  
pp. 712-721 ◽  
Author(s):  
Emily A. Bermel ◽  
Victor H. Barocas ◽  
Arin M. Ellingson
Keyword(s):  
Spinal Stability ◽  
Capsular Ligament

AT1 receptor block does not affect arterial baroreflex during pregnancy in rabbits

2001 ◽  
Vol 280 (5) ◽  
pp. H1996-H2005 ◽  
Author(s):  
Kathleen P. O'Hagan ◽  
Kara A. Skogg ◽  
Jennifer B. Stevenson
Keyword(s):  
Sympathetic Nerve Activity ◽  
Ang Ii ◽  
Arterial Baroreflex ◽  
Baroreflex Control ◽  
Renal Sympathetic Nerve Activity ◽  
Sympathetic Response ◽  
Reflex Gain ◽  
Receptor Block ◽  
Renal Sympathetic

The role of ANG II in the arterial baroreflex control of renal sympathetic nerve activity (RSNA) in eight term-pregnant (P) and eight nonpregnant (NP) conscious rabbits was assessed using sequential intracerebroventricular and intravenous infusions of losartan, an AT1 receptor antagonist. The blood pressure (BP)-RSNA relationship was generated by sequential inflations of aortic and vena caval perivascular occluders. Pregnant rabbits exhibited a lower maximal RSNA reflex gain (−44%) that was primarily due to a reduction in the maximal sympathetic response to hypotension (P, 248 ± 20% vs. NP, 357 ± 41% of rest RSNA, P < 0.05). Intracerebroventricular losartan decreased resting BP in P (by 9 ± 3 mmHg, P < 0.05) but not NP rabbits, and had no effect on the RSNA baroreflex in either group. Subsequent intravenous losartan decreased resting BP in NP and further decreased BP in P rabbits, but had no significant effect on the maximal RSNA reflex gain. ANG II may have an enhanced role in the tonic support of BP in pregnancy, but does not mediate the gestational depression in the arterial baroreflex control of RSNA in rabbits.

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