Bisphosphate nucleotidase 2 (BPNT2), a molecular target of lithium, regulates chondroitin sulfation patterns in the cerebral cortex and hippocampus

Development of oligodendrocytes in rat corpus callosum was described as a sequential change in cytoplasmic density which progressed from light to medium to dark (1). In rat optic nerve, changes in cytoplasmic density were not observed, but significant changes in morphology occurred just prior to and during myelination (2). In our study, the ultrastructural development of oligodendrocytes was studied in newborn, 5-, 10-, 15-, 20-day and adult frontal cortex of the golden hamster (Mesocricetus auratus).Young and adult hamster brains were perfused with paraformaldehyde-glutaraldehyde in sodium cacodylate buffer at pH 7.3 according to the method of Peters (3). Tissue samples of layer V of the frontal cortex were post-fixed in 2% osmium tetroxide, dehydrated in acetone and embedded in Epon-Araldite resin.

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Glucuronyl 3-sulfate occurs exclusively on distal unmyelinated terminals of selected sensory neurons in the peripheral nervous system

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100141160 ◽

1995 ◽

Vol 53 ◽

pp. 958-959

Author(s):

S.S. Spicer ◽

B.A. Schulte

Keyword(s):

Central Nervous System ◽

Nervous System ◽

Cerebral Cortex ◽

Peripheral Nervous System ◽

Sensory Neurons ◽

Sensory Nerves ◽

Tissue Antigens ◽

The Central Nervous System ◽

The Brain ◽

Leu 7

Generation of monoclonal antibodies (MAbs) against tissue antigens has yielded several (VC1.1, HNK- 1, L2, 4F4 and anti-leu 7) which recognize the unique sugar epitope, glucuronyl 3-sulfate (Glc A3- SO4). In the central nervous system, these MAbs have demonstrated Glc A3-SO4 at the surface of neurons in the cerebral cortex, the cerebellum, the retina and other widespread regions of the brain.Here we describe the distribution of Glc A3-SO4 in the peripheral nervous system as determined by immunostaining with a MAb (VC 1.1) developed against antigen in the cat visual cortex. Outside the central nervous system, immunoreactivity was observed only in peripheral terminals of selected sensory nerves conducting transduction signals for touch, hearing, balance and taste. On the glassy membrane of the sinus hair in murine nasal skin, just deep to the ringwurt, VC 1.1 delineated an intensely stained, plaque-like area (Fig. 1). This previously unrecognized structure of the nasal vibrissae presumably serves as a tactile end organ and to our knowledge is not demonstrable by means other than its selective immunopositivity with VC1.1 and its appearance as a densely fibrillar area in H&E stained sections.

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Visual Spatial Attention in Migraine Sufferers in Postictal and Interictal Phases: An Event-Related Potential Study

Journal of Psychophysiology ◽

10.1027//0269-8803.15.1.22 ◽

2001 ◽

Vol 15 (1) ◽

pp. 22-34 ◽

Cited By ~ 2

Author(s):

D.H. de Koning ◽

J.C. Woestenburg ◽

M. Elton

Keyword(s):

Cerebral Cortex ◽

Visual Attention ◽

Migraine Attack ◽

Spatial Attention ◽

Event Related Potential ◽

Significant Enhancement ◽

Pathophysiological Mechanism ◽

Attention Task ◽

Visual Spatial Attention ◽

Visual Spatial

Migraineurs with and without aura (MWAs and MWOAs) as well as controls were measured twice with an interval of 7 days. The first session of recordings and tests for migraineurs was held about 7 hours after a migraine attack. We hypothesized that electrophysiological changes in the posterior cerebral cortex related to visual spatial attention are influenced by the level of arousal in migraineurs with aura, and that this varies over the course of time. ERPs related to the active visual attention task manifested significant differences between controls and both types of migraine sufferers for the N200, suggesting a common pathophysiological mechanism for migraineurs. Furthermore, migraineurs without aura (MWOAs) showed a significant enhancement for the N200 at the second session, indicating the relevance of time of measurement within migraine studies. Finally, migraineurs with aura (MWAs) showed significantly enhanced P240 and P300 components at central and parietal cortical sites compared to MWOAs and controls, which seemed to be maintained over both sessions and could be indicative of increased noradrenergic activity in MWAs.

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