Anti-cyclic citrullinated peptide (anti-CCP) antibody in juvenile idiopathic arthritis (JIA): Correlations with disease activity and severity of joint damage (a multicenter trial)

2013 ◽  
Vol 80 (1) ◽  
pp. 38-43 ◽  
Author(s):  
Aziza Omar ◽  
Ihab Abo-Elyoun ◽  
Hanan Hussein ◽  
Mohammad Nabih ◽  
Hoda Atwa ◽  
...  
Keyword(s):  
Juvenile Idiopathic Arthritis ◽  
Disease Activity ◽  
Joint Damage ◽  
Multicenter Trial ◽  
Cyclic Citrullinated Peptide ◽  
Citrullinated Peptide

scholarly journals ASSOCIATION OF ANTI-CYCLIC CITRULLINATED PEPTIDE ANTIBODY IN A SAMPLE OF ADULT PATIENTS WITH PSORIASIS AND PSORIATIC ARTHROPATHY

2018 ◽  
Vol 11 (11) ◽  
pp. 385
Author(s):  
Khudair Al-bedri ◽  
Zainab A Mahmood ◽  
Aqeel Hussein Sadeq
Keyword(s):  
Disease Activity ◽  
Joint Damage ◽  
Adult Patients ◽  
Psoriatic Arthropathy ◽  
Cyclic Citrullinated Peptide ◽  
Hospital Units ◽  
Persistent Inflammation ◽  
Number Of Patients ◽  
Significant Difference ◽  
Citrullinated Peptide

Objective: Psoriatic arthritis (PsA) is a chronic inflammatory arthropathy commonly associated with psoriasis, a large number of patients with PsA that has persistent inflammation may develop progressive joint damage and disability and have reduced life expectancy. This study aims to determine the associations of anti-cyclic citrullinated peptide (CCP) antibodies in adult patients with psoriasis and PsA.Methods: A case–control study was conducted at Baghdad teaching hospital, Units of Rheumatology and Dermatology, during the period from December 2016 to April 2017 including three groups; 40 patients with psoriasis, 40 patients with PsA fulfilling the CASPAR classification criteria, and 40 healthy control persons.Results: Two patients with psoriasis (5%) and 10 patients with PsA (25%) were seropositive for anti-CCP antibodies (ACPA). Healthy controls were negative for anti-CCPA. Regarding ACPA positivity, a significant difference was found between those three studied groups (p<0.001) and there was a significant difference between positive and negative ACPA in PsA patients regarding disease activity score (p=0.044).Conclusion: Positive ACPA were found more significant with PsA than in patients with psoriasis as well as associated with higher disease activity.

The prevalence of anti-cyclic citrullinated peptide antibodies in juvenile idiopathic arthritis

2005 ◽  
Vol 0 (0) ◽  
Author(s):  
Sandra H. Machado ◽  
Carlos A. von Mühlen ◽  
João C. T. Brenol ◽  
Letícia Bisotto ◽  
Ricardo Machado Xavier
Keyword(s):  
Juvenile Idiopathic Arthritis ◽  
Cyclic Citrullinated Peptide ◽  
Citrullinated Peptide ◽  
Peptide Antibodies

scholarly journals Anti-cyclic citrullinated peptide antibodies in children with Juvenile Idiopathic Arthritis

10.19082/2897 ◽  
2016 ◽  
Vol 8 (9) ◽  
pp. 2897-2903 ◽  
Author(s):  
Mohamed Hamooda ◽  
Hala Fouad ◽  
Nermeen Galal ◽  
Nadia Sewelam ◽  
Dina Megahed
Keyword(s):  
Juvenile Idiopathic Arthritis ◽  
Cyclic Citrullinated Peptide ◽  
Citrullinated Peptide ◽  
Peptide Antibodies

scholarly journals Impact of baseline anti-cyclic citrullinated peptide-2 antibody concentration on efficacy outcomes following treatment with subcutaneous abatacept or adalimumab: 2-year results from the AMPLE trial

2015 ◽  
Vol 75 (4) ◽  
pp. 709-714 ◽  
Author(s):  
Jeremy Sokolove ◽  
Michael Schiff ◽  
Roy Fleischmann ◽  
Michael E Weinblatt ◽  
Sean E Connolly ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Disease Activity ◽  
Clinical Outcomes ◽  
Antibody Concentration ◽  
Treatment Groups ◽  
Cyclic Citrullinated Peptide ◽  
Remission Rates ◽  
Registration Number ◽  
Baseline Characteristics ◽  
Citrullinated Peptide

ObjectivesTo examine whether baseline anti-cyclic citrullinated peptide-2 (CCP2) antibody status and concentration correlated with clinical outcomes in patients treated with abatacept or adalimumab on background methotrexate (MTX) in the 2-year AMPLE (Abatacept versus adaliMumab comParison in bioLogic-naïvE rheumatoid arthritis subjects with background MTX) study.MethodsIn this exploratory analysis, anti-CCP2 antibody concentration was measured at baseline, and antibody-positive patients were divided into equal quartiles, Q1–Q4, representing increasing antibody concentrations. Clinical outcomes analysed by baseline anti-CCP2 status and quartile included change from baseline in disease activity and disability and remission rates.ResultsBaseline characteristics were generally comparable across quartiles and treatment groups. In both treatment groups, anti-CCP2 antibody-negative patients responded less well than antibody-positive patients. At year 2, improvements in disease activity and disability and remission rates were similar across Q1–Q3, but were numerically higher in Q4 in the abatacept group; in contrast, treatment effects were similar across all quartiles in the adalimumab group.ConclusionsIn AMPLE, baseline anti-CCP2 positivity was associated with a better response for abatacept and adalimumab. Patients with the highest baseline anti-CCP2 antibody concentrations had better clinical response with abatacept than patients with lower concentrations, an association that was not observed with adalimumab.Trial registration numberNCT00929864.

Development and preliminary validation of a paediatric-targeted MRI scoring system for the assessment of disease activity and damage in juvenile idiopathic arthritis

2010 ◽  
Vol 70 (3) ◽  
pp. 440-446 ◽  
Author(s):  
Clara Malattia ◽  
Maria Beatrice Damasio ◽  
Angela Pistorio ◽  
Maka Ioseliani ◽  
Iris Vilca ◽  
...  
Keyword(s):  
Juvenile Idiopathic Arthritis ◽  
Construct Validity ◽  
Disease Activity ◽  
Scoring System ◽  
Bone Erosion ◽  
Joint Damage ◽  
Targeted Mri ◽  
Mri Score ◽  
Responsiveness To Change ◽  
Assessment Of Disease Activity

ObjectivesTo develop and validate a paediatric-targeted MRI scoring system for the assessment of disease activity and damage in juvenile idiopathic arthritis (JIA). To compare the paediatric MRI score with the adult-designed. Outcome Measures in Rheumatology Clinical Trials—Rheumatoid Arthritis MRI Score (RAMRIS), whose suitability for assessing growing joints was tested.MethodsIn 66 patients with JIA the clinically more affected wrist was studied. Thirty-nine patients had a 1-year MRI follow-up. Two readers independently assigned the paediatric score and the RAMRIS to all studies. Validation procedures included analysis of reliability, construct validity and responsiveness to change. A reduced version of the bone erosion score was also developed and tested.ResultsThe paediatric score showed an excellent reproducibility (interclass correlation coefficient >0.9). The interobserver agreement of RAMRIS was moderate for bone erosions and excellent for bone marrow oedema (BMO). The paediatric score and RAMRIS provided similar results for construct validity. The responsiveness to change of the paediatric score was moderate for synovitis and bone erosion, and poor for BMO and did not improve when RAMRIS was applied. The reduced version of the bone erosion was valuable for the assessment of joint damage, and provided time-saving advantages.ConclusionThe results demonstrate that the paediatric MRI score is a reliable and valid method for assessing disease activity and damage in JIA. Unexpectedly, the RAMRIS provides acceptable suitability for use in the paediatric age group. Further work, especially in a longitudinal setting, is required before defining the most suitable MRI scale for assessing growing joints.

scholarly journals Study on the evaluation of rheumatoid arthritis via doppler ultrasonography and anti-cyclic citrullinated peptide antibody analysis

2020 ◽  
Vol 36 (3) ◽  
Author(s):  
Li-na Shang ◽  
Gui-xin Di ◽  
Feng-ju Wei ◽  
Zheng Zhang
Keyword(s):  
Rheumatoid Arthritis ◽  
Disease Activity ◽  
Doppler Ultrasonography ◽  
Severe Disease ◽  
Joint Involvement ◽  
Cyclic Citrullinated Peptide ◽  
Mild Disease ◽  
Number Of Patients ◽  
Peptide Antibody ◽  
Citrullinated Peptide

Objective: This study aims to discuss the value of ultrasonic analysis and anti-cyclic citrullinated peptide (CCP) antibody analysis in evaluating the state of rheumatoid arthritis (RA). Methods: This study was conducted during March 2016 to December 2016. Total 82 patients with RA who sought treatment in the Affiliated Hospital of Hebei University were included in this study. Data on ultrasonic and anti-CCP antibody, ESR, and RF were collected and compared. The RA patients were divided into two groups of mild disease activity (DAS28 ≤ 3.2) and moderate-severe disease activity (DAS28 > 3.2) to compare the changes in synovial thickness of joints. The changes of joint ultrasonography were also compared between positive and negative anti-CCP antibodies group. Results: It is found that the number of patients suffering from joint involvement in the negative anti-CCP antibody group was larger than that of the anti-CCP positive antibody group (P <0.05); the thickness of the synovium of joints of patients in the group with moderate-severe disease activity evaluated via ultrasonography was significantly larger than that of the group with mild disease activity (P <0.05). Conclusion: It is possible to observe the degree of disease activity dynamically by combining ultrasonography with anti-CCP antibody and make a better assessment of patients to facilitate treatment. doi: https://doi.org/10.12669/pjms.36.3.1492 How to cite this:Shang L, Di G, Wei F, Zhang Z. Study on the evaluation of rheumatoid arthritis via doppler ultrasonography and anti-cyclic citrullinated peptide antibody analysis. Pak J Med Sci. 2020;36(3):---------. doi: https://doi.org/10.12669/pjms.36.3.1492 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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