Clinical and prognostic significance of antinuclear antibodies in primary antiphospholipid syndrome: French multicenter retrospective study

Abstract Background There is uncertainty surrounding the prognostic value of peritoneal cytology in low-risk endometrial cancer, especially in laparoscopic surgery. The objective of this retrospective study is to determine the prognostic significance of positive peritoneal cytology among patients with low-risk endometrial cancer and to compare it between laparoscopic surgery and conventional laparotomy. Methods From August 2008 to December 2019, all cases of pathologically confirmed stage IA grade 1 or 2 endometrial cancer were reviewed at Osaka Medical College. Statistical analyses used the Chi-square test and the Kaplan–Meier log rank. Results A total of 478 patients were identified: 438 with negative peritoneal cytology (232 who underwent laparotomy and 206 who undertook laparoscopic surgery) and 40 with positive peritoneal cytology (20 who underwent laparotomy and 20 who received laparoscopic surgery). Survival was significantly worse among patients with positive peritoneal cytology compared to patients with negative peritoneal cytology. However, there was no significant difference among patients with negative or positive peritoneal cytology between laparoscopic surgery and laparotomy. Conclusion This retrospective study suggests that, while peritoneal cytology is an independent risk factor in patients with low-risk endometrial cancer, laparoscopic surgery does not influence the survival outcome when compared to laparotomy.

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Preeclampsia in primary antiphospholipid syndrome is associated with fetal losses and limb ischemia

Clinical Rheumatology ◽

10.1007/s10067-021-05626-6 ◽

2021 ◽

Author(s):

Jozélio Freire de Carvalho ◽

Maria Betania Pereira Toralles ◽

Maria Isabel Figueiredo Sousa ◽

Thelma Larocca Skare

Keyword(s):

Antiphospholipid Syndrome ◽

Limb Ischemia ◽

Primary Antiphospholipid Syndrome

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Cold Agglutinin-Mediated Autoimmune Hemolytic Anemia in Association with Antiphospholipid Syndrome

Acta Haematologica ◽

10.1159/000516295 ◽

2021 ◽

pp. 1-4

Author(s):

Ram Gelman ◽

Fadi Kharouf ◽

Yuval Ishay ◽

Alexander Gural

Keyword(s):

Hemolytic Anemia ◽

Antiphospholipid Syndrome ◽

Complement Activation ◽

Autoimmune Hemolytic Anemia ◽

Cold Agglutinin ◽

Primary Antiphospholipid Syndrome ◽

Unique Case ◽

Hematologic Disorders ◽

Clear Association ◽

Immune Mediated

Antiphospholipid syndrome and cold agglutinin-mediated autoimmune hemolytic anemia are 2 distinct immune-mediated hematologic disorders. While no clear association exists between these 2 entities, complement activation is known to occur in both of them. Herein, we report a unique case of cold agglutinin hemolytic anemia in a patient with a known primary antiphospholipid syndrome.

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Case of an unusual diagnosis of primary antiphospholipid syndrome with multiple clinical complications

Oxford Medical Case Reports ◽

10.1093/omcr/omaa117 ◽

2020 ◽

Vol 2020 (12) ◽

Author(s):

Stathis Tsiakas ◽

Chrysanthi Skalioti ◽

Paraskevi Kotsi ◽

Ioannis Boletis ◽

Smaragdi Marinaki

Keyword(s):

Antiphospholipid Syndrome ◽

Thrombotic Event ◽

Renal Involvement ◽

Clinical Manifestations ◽

Young Male ◽

Multiple Organ ◽

Systemic Autoimmune Disease ◽

Antiphospholipid Antibody ◽

Primary Antiphospholipid Syndrome ◽

Wide Range

ABSTRACT Antiphospholipid syndrome (APS) is a systemic autoimmune disease defined by the presence of antiphospholipid antibodies in association with thrombotic events and/or obstetric complications. Renal involvement is not infrequent in both primary and secondary APS. Kidney manifestations comprise a wide range of clinical features, including hypertension, major renal vessel thrombosis or microvascular endothelial injury, also described as APS nephropathy. In the absence of a thrombotic event, clinical manifestations of APS are often non-specific. We recently encountered a case of primary APS in a young male with newly diagnosed hypertension and renal impairment. The diagnosis of APS was initially suspected by his kidney biopsy findings, when electron microscopy examination showed the features of chronic microangiopathy, and was later confirmed by a triple positive antiphospholipid antibody profile and multiple organ involvement.

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