scholarly journals Incidence and Risk Factors for Hepatitis C Virus and Hepatitis B Virus Seroconversion in End-Stage Renal Failure Patients on Maintenance Hemodialysis

2020 ◽  
Vol 10 (4) ◽  
pp. 316-321
Author(s):  
Manik Kataruka ◽  
Shefali Gupta ◽  
Raja Ramchandran ◽  
Mini Singh ◽  
Radha Krishan Dhiman ◽  
...  
Keyword(s):  
Risk Factors ◽  
Renal Failure ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Maintenance Hemodialysis ◽  
End Stage Renal Failure ◽  
B Virus ◽  
End Stage

scholarly journals Epidemiology of Hepatitis B Virus (HBV) and Hepatitis C Virus (HCV) Related Hepatocellular Carcinoma

2018 ◽  
Vol 12 (1) ◽  
pp. 26-32 ◽  
Author(s):  
Arnolfo Petruzziello
Keyword(s):  
Risk Factors ◽  
Hepatocellular Carcinoma ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Hbv Infection ◽  
Sub Saharan Africa ◽  
Liver Cancers ◽  
B Virus

Introduction:Hepatocellular carcinoma (HCC) is one of the most prevalent primary malignant tumors and accounts for about 90% of all primary liver cancers. Its distribution varies greatly according to geographic location and it is more common in middle and low- income countries than in developed ones especially in Eastern Asia and Sub Saharan Africa (70% of all new HCCs worldwide), with incidence rates of over 20 per 100,000 individuals.Explanation:The most important risk factors for HCC are Hepatitis B Virus (HBV) infection, Hepatitis C Virus (HCV) infection, excessive consumption of alcohol and exposition to aflatoxin B1. Its geographic variability and heterogeneity have been widely associated with the different distribution of HBV and HCV infections worldwide.Chronic HBV infection is one of the leading risk factors for HCC globally accounting for at least 50% cases of primary liver tumors worldwide. Generally, while HBV is the main causative agent in the high incidence HCC areas, HCV is the major etiological factor in low incidence HCC areas, like Western Europe and North America.Conclusion:HBV-induced HCC is a complex, stepwise process that includes integration of HBV DNA into host DNA at multiple or single sites. On the contrary, the cancerogenesis mechanism of HCV is not completely known and it still remains controversial as to whether HCV itself plays a direct role in the development of tumorigenic progression.

Risk Factors and Seroprevalence of Hepatitis B Virus, Hepatitis C Virus, and Human Immunodeficiency Virus Infection in Uzbekistan

Intervirology ◽  
2001 ◽  
Vol 44 (6) ◽  
pp. 327-332 ◽  
Author(s):  
Ruslan Ruzibakiev ◽  
Hideaki Kato ◽  
Ryuzo Ueda ◽  
Nodira Yuldasheva ◽  
Tatyana Hegay ◽  
...  
Keyword(s):  
Risk Factors ◽  
Human Immunodeficiency Virus ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Hepatitis B Virus ◽  
Virus Infection ◽  
Hepatitis B ◽  
Virus Hepatitis ◽  
B Virus ◽  
Immunodeficiency Virus

HIV, hepatitis B virus, hepatitis C virus, and syphilis among pregnant women attending antenatal care in Luanda, Angola: Seroprevalence and risk factors

2020 ◽  
Vol 92 (12) ◽  
pp. 3265-3270
Author(s):  
Cruz S. Sebastião ◽  
Zoraima Neto ◽  
Domingos Jandondo ◽  
Marinela Mirandela ◽  
Joana Morais ◽  
...  
Keyword(s):  
Risk Factors ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Antenatal Care ◽  
Pregnant Women ◽  
Virus Hepatitis ◽  
B Virus

scholarly journals Molecular Pathogenesis of Hepatocellular Carcinoma

2007 ◽  
Vol 10 (2) ◽  
pp. 15-22 ◽  
Author(s):  
S Metodieva
Keyword(s):  
Risk Factors ◽  
Hepatocellular Carcinoma ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Hepatitis B Virus ◽  
Tumor Suppressor ◽  
Hepatitis B ◽  
Aflatoxin B1 ◽  
Molecular Pathogenesis ◽  
B Virus

Molecular Pathogenesis of Hepatocellular CarcinomaThe most important risk factors for the development of human hepatocellular carcinoma (HCC) are chronic infection with hepatitis B virus (HBV) and/or hepatitis C virus (HCV), high dietary exposure to hepatic carcinogen aflatoxin B1 and alcohol abuse. Hepatitis B virus exerts its effects through integration of the viral DNA into the hepatocyte genome, or through acting as transcriptional regulator for several cellular proto-oncogenes and tumor-suppressor genes. Hepatitis C virus may affect hepatocytes via the transcriptional regulation activity of the HCV core protein or via the HCV non structural proteins NS5A, NS5B and NS2, interfering with the regulation of cell cycle and apoptosis. Environmental exposure to aflatoxin B1 can cause a specific missense mutation in codon 249 of the p53 tumor-suppressor gene. Habitual alcohol consumption leads to production of reactive oxygen species and peroxidation damage to DNA. The objective of this review is to make you acquainted with the most common risk factors and the most frequent genetic aberrations associated with the development of HCC.

Sign in / Sign up

Export Citation Format

Share Document