scholarly journals CRT-146 Follow-up Results And Health-related Quality-of-life After Implantation Of Left Ventricular Passive Containment Device For Heart Failure And Dilated Cardiomyopathy

2013 ◽  
Vol 6 (2) ◽  
pp. S48-S49
Author(s):  
Giuseppe Nasso ◽  
Raffaele Bonifazi ◽  
Vito Romano ◽  
Felice Piancone ◽  
Giuseppe Visicchio ◽  
...  
2020 ◽  
Vol 41 (Supplement_2) ◽  
Author(s):  
C Proudfoot ◽  
A.F Fonseca ◽  
R Lahoz ◽  
S Corda ◽  
S Cotton ◽  
...  

Abstract Background and purpose Heart Failure (HF) is associated with symptoms such as dyspnoea and fatigue which can impact patients' health related quality of life (HRQoL). This study aimed to characterize and assess the HRQoL of patients with HF and left-ventricular ejection fraction (LVEF) <40% versus those with ≥40%-60%. Methods A cross-sectional study of patients with HF was conducted in France, Germany, Italy, Spain and United Kingdom. Patient record forms (PRFs) were completed by 257 cardiologists and 158 general practitioners (GPs) for consecutively consulting patients. The same patients were invited to provide patient-reported outcomes including self-completion questionnaires, Minnesota Living with Heart Failure Questionnaire (MLHFQ) and EQ-5D-5L VAS. Results 204 HF patients with LVEF <40% (mean age 67.7 years) and 600 patients with LVEF ≥40–60% (mean age 68.9 years) were included. Proportion of males was significantly higher in the lower LVEF group (73.5% vs. 61.2%, p=0.0017). Overall, the patients with lower LVEF more frequently presented with comorbidities than those with LVEF ≥40–60% (p<0.05, Figure 1). NYHA stage III/IV (35.8%/7.4% vs. 15.3%/0.8%) as well as self-reported HF symptoms were more frequently reported in the lower LVEF group (p<0.05, Figure 1). Similarly, patients with LVEF <40% reported statistically significantly worse HRQoL compared to those with LVEF ≥40–60% (Table 1). Conclusions The HRQoL of all HF patients with LVEF ≤60% appears impacted, while those with LVEF <40% had significantly worse HRQoL than those with LVEF ≥40–60%. These differences in HRQoL may not only be related to the LVEF but also to the overall characteristics of these patients. Addressing the HRQoL burden for patients should be a key aspect of HF management strategies for all HF patients. Funding Acknowledgement Type of funding source: Private company. Main funding source(s): Novartis Pharma AG


Author(s):  
Fawad Farooq ◽  
Nida Imran ◽  
Mahwish Abbas

Abstract Objective: To determine the effect of Ivabradine in lowering heart rate and quality of life in chronic heart failure patients. Methods: The observational study was conducted in the out-patient department of the National Institute of Cardiovascular Disease, Karachi, from December 2016 to June 2017, and comprised chronic heart failure patients aged 30-70 years who were on 5mg Ivabradine for 8-weeks. Heart rate was evaluated through electrocardiogram, and health-related quality of life was measured using the validated questionnaire. Baseline demographics and clinical characteristics were recorded, with follow-ups at week-4 and week-8. Safety and tolerability were assessed by adverse drug reactions monitoring. Data was analysed using SPSS 21. Results: Of the 50 patients, 34(68%) were males. The overall mean age was 54.8±9.17 years. Baseline mean heart rate significantly reduced at first and second follow-up visit (p< 0.001). Mobility problems declined significantly as well (p<0.05). Health-related quality of life significantly improved on follow-up visits (p<0.001). Conclusion: There was significant control of heart rate in chronic heart failure patients with improvement in all parameters of quality of life. Key Words: Heart failure, Ivabradine, Heart rate, Continuous...


2019 ◽  
Vol 40 (Supplement_1) ◽  
Author(s):  
E Lambrinou ◽  
A Protopapas ◽  
V Barberis ◽  
L Paikousis ◽  
M Kyriakou ◽  
...  

Abstract Background In order to improve health-related quality of life (HR-QoL) of heart failure (HF) patients, different disease management programs have been developed at the discharged and follow-up phase. Aim To determine the effectiveness of a three-month telephone follow-up, a telephone follow-up with education before discharge, or education only before discharge (all performed by nurse specialists) on HR-QoL in HF patients. The results of the randomized clinical trial (RCT) MEETinCY are presented. Method This is a multicenter RCT with 3 different intervention groups (IGs) and one control group (CG) The first IG included only patients' education before discharge (E). The second IG included patients' education and telephone follow-up after discharge for three months (ET). The third IG included only telephone follow-up for three months (T). The Greek version of the MLHFQ was used. The statistical analysis of the impact of the intervention was done using ANCOVA. The magnitude of the effect of the intervention was studied with the Cohen's d coefficient for repeated measurements. The exploration of clinical and demographic factors in the relationship of HR-QoL was done by using linear coefficients of regression. The investigation of the robustness of the results and the intention to treat was carried out by sensitivity analysis. The management of missing value of the MLHFQ was done by using multiple imputation. Results The study included 334 patients. The analysis demonstrated that the study groups differentiates the level of HR-QoL post-intervention measurement in terms of the Overall QoL (F=2.8, 47, p=0.04). The mean level of Overall HR-QoL adjusted for the pre-intervention measurement, in the T: 40.3 (SE=2.2) and ET: 42 (2.2) groups was higher than that of the E group: 39 (2.2) and the CG: 47 (2). Study group differences were also detected statistically in the Social dimension (F=3.4, p=0.02) but not in in the Physical dimension (F=1.9, p=0.11) or the Emotional dimension (F=0.99, p=0.40). However, in the ET and T groups, higher adjusted average levels of the Physical and Social dimension are observed compared to the E and Control group. Overall, IGs exhibited low to moderate effect size improvements (drm = 0.4) while the CG had negligible improvement (drm = 0.02). Women exhibit lower overall HR-QoL scores compared to men by 13.9 points in the MLHFQ scale (b=13.9, p<0.015). NYHA IV (38.5, p<0.001), NYHA III (29.5, p<0.001) and NYHA II (9.15, p<0.001) patients exhibit worse overall HR-QoL compared to NYHA I patients. Conclusion Patients' education before discharge was not found to have an important role over the three- months telephone follow-up after discharge. On the other hand, improvement was found in patients who had the telephone intervention and the possibility to call researchers (nurses) whenever they needed. Patients seem to need continuing communication and support and to feel the availability of contacting and seeking help when needed. Acknowledgement/Funding Cyprus University of Technology's state funded budget [Startup Fund EX2007 (04)]


Author(s):  
Mario J. Olivera ◽  
Johana A. Fory ◽  
Giancarlo Buitrago

Chagas disease represents an important cause of heart failure (HF) and affects health-related quality of life (HRQoL). The study aimed to evaluate and compare the HRQoL of patients with chagasic HF and matched non-Chagas controls to identify factors associated with HRQoL. A cross-sectional study with pair-matched controls was conducted in Colombia. From October 2018 to December 2019, a total of 84 HF patients were screened for study subjects. Four were excluded, resulting in 80 patients for the analysis, among whom 40 patients with Chagas were enrolled as cases and 40 gender- and age-matched non-Chagas patients as controls. The Kansas City Cardiomyopathy Questionnaire (KCCQ) and the Minnesota Living with Heart Failure Questionnaire (MLWHFQ) were used to measure HRQoL. Demographic, clinical, and laboratory data were obtained from each subject. Health-related quality of life scores were significantly worse among the Chagas group than among the non-Chagas group in the KCCQ domains of physical functioning and symptoms and in the MLWHFQ scale. In the multivariate analysis, the variables associated with lower HRQoL scores were living alone, obesity, having less than 12 years of education, and an increase in left ventricular diameters in the systole and diastole. Health-related quality of life in patients with chronic HF is impaired across all domains. Chagas patients showed worse HRQoL scores than non-Chagas patients. Six variables, some potentially modifiable, were independently associated with worse HRQoL.


2017 ◽  
Vol 27 (6) ◽  
pp. 1194-1202 ◽  
Author(s):  
Susanna L. den Boer ◽  
Sara J. Baart ◽  
Marijke H. van der Meulen ◽  
Gabriëlle G. van Iperen ◽  
Ad P. Backx ◽  
...  

AbstractBackgroundDilated cardiomyopathy in children causes heart failure and has a poor prognosis. Health-related quality of life in this patient group is unknown. Moreover, results may provide detailed information of parents’ sense of their child’s functioning. We hypothesised that health-related quality of life, as rated by parents, and the paediatric heart failure score, as assessed by physicians, have both predictive value on outcome.Methods and resultsIn this prospective study, health-related quality of life was assessed by parent reports: the Infant Toddler Quality of Life questionnaire (0–4 years) or Child Health Questionnaire-Parent Form 50 (4–18 years) at 3–6-month intervals. We included 90 children (median age 3.8 years, interquartile range (IQR) 0.9–12.3) whose parents completed 515 questionnaires. At the same visit, physicians completed the New York University Pediatric Heart Failure Index. Compared with Dutch normative data, quality of life was severely impaired at diagnosis (0–4 years: 7/10 subscales and 4–18 years: 8/11 subscales) and ⩾1 year after diagnosis (3/10 and 6/11 subscales). Older children were more impaired (p<0.05). After a median follow-up of 3 years (IQR 2–4), 15 patients underwent transplantation. Using multivariable time-dependent Cox regression, “physical functioning” subscale and the Heart Failure Index were independently predictive of the risk of death and heart transplantation (hazard ratio 1.24 per 10% decrease of predicted, 95% confidence interval (CI) 1.06–1.47 and hazard ratio 1.38 per unit, 95% CI 1.19–1.61, respectively).ConclusionPhysical impairment rated by parents and heart failure severity assessed by physicians independently predicted the risk of death or heart transplantation in children with dilated cardiomyopathy.


2021 ◽  
Vol 15 (6) ◽  
pp. 1349-1351
Author(s):  
I. Zia ◽  
S. Waqas ◽  
H. M. Asim ◽  
M. Tariq ◽  
A. Shahzad

Aim: To describe health related quality of life using Minnesota Living with Heart Failure Questionnaire (MLWHFQ) in individuals of LVDD post six months. Methods: Descriptive cross sectional survey on 72 individuals of LVDD post six months was conducted. Sample was calculated by WHO sample size calculator keeping μ as 0.49, margin of error as 5% and confidence interval as 95%. Data was collected by MLWHFQ via interview method with Non probability convenience sampling technique from Punjab Institute of Cardiology Lahore and Sheikh Zayed Hospital Lahore during August 2018 to January 2019. Stable individuals both male and female were recruited who aged between 50-71 years old. The baseline characteristic taken in account was NYHA of Heart Failure greater than 2, 50% or more Ejection Fraction, Diastolic Dysfunction (grade ≥1) and at least one of the positive cardiovascular risk factor. Results: Out of a total 72 subjects 41 were males and 31 were females with scores on MLWHFQ showed that out of a total 72 LVDD, HRQOL of 3(4.2%) patients were not affected, 3(4.2%) were very little effected, 7(9.7%) were little effected, 4(5.7%) was moderately effected, 34(47.2%) were much effected and 21(29.2%) were very much effected. Conclusion: The study concluded that health related quality of life using was found out to be much effected in subjects of Left Ventricular diastolic Dysfunction. Keywords: Quality of life, Left Ventricular diastolic dysfunction, Cardiac Disease


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