scholarly journals Comparison of Health-Related Quality of Life in Outpatients with Chagas and Matched Non-Chagas Chronic Heart Failure in Colombia: A Cross-Sectional Analysis

Author(s):  
Mario J. Olivera ◽  
Johana A. Fory ◽  
Giancarlo Buitrago

Chagas disease represents an important cause of heart failure (HF) and affects health-related quality of life (HRQoL). The study aimed to evaluate and compare the HRQoL of patients with chagasic HF and matched non-Chagas controls to identify factors associated with HRQoL. A cross-sectional study with pair-matched controls was conducted in Colombia. From October 2018 to December 2019, a total of 84 HF patients were screened for study subjects. Four were excluded, resulting in 80 patients for the analysis, among whom 40 patients with Chagas were enrolled as cases and 40 gender- and age-matched non-Chagas patients as controls. The Kansas City Cardiomyopathy Questionnaire (KCCQ) and the Minnesota Living with Heart Failure Questionnaire (MLWHFQ) were used to measure HRQoL. Demographic, clinical, and laboratory data were obtained from each subject. Health-related quality of life scores were significantly worse among the Chagas group than among the non-Chagas group in the KCCQ domains of physical functioning and symptoms and in the MLWHFQ scale. In the multivariate analysis, the variables associated with lower HRQoL scores were living alone, obesity, having less than 12 years of education, and an increase in left ventricular diameters in the systole and diastole. Health-related quality of life in patients with chronic HF is impaired across all domains. Chagas patients showed worse HRQoL scores than non-Chagas patients. Six variables, some potentially modifiable, were independently associated with worse HRQoL.

2020 ◽  
Vol 41 (Supplement_2) ◽  
Author(s):  
C Proudfoot ◽  
A.F Fonseca ◽  
R Lahoz ◽  
S Corda ◽  
S Cotton ◽  
...  

Abstract Background and purpose Heart Failure (HF) is associated with symptoms such as dyspnoea and fatigue which can impact patients' health related quality of life (HRQoL). This study aimed to characterize and assess the HRQoL of patients with HF and left-ventricular ejection fraction (LVEF) <40% versus those with ≥40%-60%. Methods A cross-sectional study of patients with HF was conducted in France, Germany, Italy, Spain and United Kingdom. Patient record forms (PRFs) were completed by 257 cardiologists and 158 general practitioners (GPs) for consecutively consulting patients. The same patients were invited to provide patient-reported outcomes including self-completion questionnaires, Minnesota Living with Heart Failure Questionnaire (MLHFQ) and EQ-5D-5L VAS. Results 204 HF patients with LVEF <40% (mean age 67.7 years) and 600 patients with LVEF ≥40–60% (mean age 68.9 years) were included. Proportion of males was significantly higher in the lower LVEF group (73.5% vs. 61.2%, p=0.0017). Overall, the patients with lower LVEF more frequently presented with comorbidities than those with LVEF ≥40–60% (p<0.05, Figure 1). NYHA stage III/IV (35.8%/7.4% vs. 15.3%/0.8%) as well as self-reported HF symptoms were more frequently reported in the lower LVEF group (p<0.05, Figure 1). Similarly, patients with LVEF <40% reported statistically significantly worse HRQoL compared to those with LVEF ≥40–60% (Table 1). Conclusions The HRQoL of all HF patients with LVEF ≤60% appears impacted, while those with LVEF <40% had significantly worse HRQoL than those with LVEF ≥40–60%. These differences in HRQoL may not only be related to the LVEF but also to the overall characteristics of these patients. Addressing the HRQoL burden for patients should be a key aspect of HF management strategies for all HF patients. Funding Acknowledgement Type of funding source: Private company. Main funding source(s): Novartis Pharma AG


2012 ◽  
Vol 27 (3) ◽  
pp. 686-694 ◽  
Author(s):  
Nikolaos V. Fotos ◽  
Konstantinos Giakoumidakis ◽  
Zoi Kollia ◽  
Petros Galanis ◽  
Panagiota Copanitsanou ◽  
...  

Author(s):  
Gerhard Schmalz ◽  
Christian Binner ◽  
Mirjam Eisner ◽  
Justus Wagner ◽  
Josephine Rast ◽  
...  

Abstract Objectives The aim of this cross-sectional study was to compare oral health-related quality of life (OHRQoL) of patients with left ventricular assist device (LVAD) and heart failure (HF). Material and methods Seventy-four patients with LVAD were recruited from University Department for Cardiac Surgery, Leipzig Heart Center, Germany. A group of 72 patients with HF was composed by matching (age, gender, smoking). The German short form of oral health impact profile (OHIP G14) was applied. Health-related quality of life (HRQoL) was measured by short form 36 survey (SF-36). Dental conditions (decayed-, missing- and filled-teeth [DMF-T]), remaining teeth and periodontal findings were assessed. Statistics: t-test, Mann-Whitney U test, Kruskal-Wallis test, chi-square or Fisher test, linear regression. Results Age, gender, smoking, underlying disease, co-morbidities and oral findings were comparable between groups (p > 0.05). OHIP G14 sum score was 3.53 ± 6.82 (LVAD) and 2.92 ± 5.35 (HF; p = 0.70), respectively. The scales SF-36 physical functioning (p = 0.05) and SF-36 social functioning (p < 0.01) were worse in LVAD. In the LVAD group, the DMF-T and remaining teeth negatively correlated with OHIP G14 sum score (p < 0.01). In HF patients, positive correlations were found between OHIP G14 and D-T (p < 0.01) and remaining teeth (p = 0.04). Moreover, DMF-T (p = 0.03) and remaining molars/premolars (p = 0.02) were negatively correlated with SF-36 scales in HF. Conclusions Oral health and OHRQoL was comparable between LVAD and HF; thereby, OHRQoL reflected the clinical oral status. Clinical relevance Dental care, with beginning in early stage of HF, should be fostered to preserve teeth and support quality of life before and after LVAD implantation.


2020 ◽  
Vol 13 (Suppl_1) ◽  
Author(s):  
Mohammed O Alanazi ◽  
Gwen Wyatt ◽  
Ann Annis ◽  
Rebecca Lehto

Purpose: Heart failure (HF) is associated with poor health-related quality of life (HRQoL) secondary to decrements in functional status. Patients’ adoption of coping strategies may affect their HRQoL. The review purpose was to characterize what is known about factors that impact selection of coping strategies that contribute to HRQoL among HF patients. Research Question/Hypothesis: What is known about: 1) the impact of coping strategies on HRQoL among patients with HF; and 2) factors affecting the adoption of coping strategies? Theoretical framework/rationale: This review was guided by Lazarus and Folkman’s stress and coping theory. Methods: A scoping review was conducted using the Arksey and O’Malley framework and a modified Preferred Reporting Items for Systematic Reviews and Meta-Analyses. Databases searched included PubMed, Web of Science, Cochrane, CINAHL, and PsycINFO. Keywords included: cope, coping, HF, congestive HF, HRQoL, coping strategies. Two investigators came to consensus on publications meeting eligibility criteria. Results: 674 articles were identified of which 471 articles were screened by title and abstract after duplicates were removed, with 27 meeting eligibility. 25 studies were quantitative and 2 qualitative. Six studies were randomized controlled trials, 18 were cross-sectional, and one was longitudinal. Participants’ ages ranged in age from 49-79. Most studies (n=18) reported a significant impact of coping strategies on HRQoL in HF patients, and six studies reported minimum to no impact. Factors that influenced the adoption of coping strategies were reported (n=7 studies): age, gender, religious belief, culture, depression and illness severity. Four of the seven studies reported depression as a significant factor in adopting coping strategies. Conclusion: Most studies found a significant impact on HRQoL through coping among HF patients. However, the majority of studies were cross-sectional in design, highlighting difficulties in determining causal relationships and changes over time. While only seven studies addressed factors that led to the use of coping strategies in HF, the leading contributors were sociodemographics along with depression. This review provides an overview of the state of science; lack of experimental studies suggests a gap in the literature and a need to explore this area of research.


2020 ◽  
Vol 99 (9) ◽  
pp. 2037-2046
Author(s):  
Yannis Dimitroglou ◽  
Fotios Anagnostopoulos ◽  
Constantina Aggeli ◽  
Sophia Delicou ◽  
Aikaterini Xydaki ◽  
...  

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