Effect of nasal or nasopharyngeal apneic oxygenation on desaturation during induction of anesthesia and endotracheal intubation in the operating room: A narrative review of randomized controlled trials

ABSTRACTObjective:Hematopoietic syndrome (HS) is a clinical diagnosis assigned to people who present with ≥1 new-onset cytopenias in the setting of acute radiation exposure. The World Health Organization convened a panel of experts to evaluate the evidence and develop recommendations for medical countermeasures for the management of HS in a hypothetical scenario involving the hospitalization of 100 to 200 individuals exposed to radiation. The objective of this consultancy was to develop recommendations for treatment of the HS based upon the quality of evidence.Methods:English-language articles were identified in MEDLINE and PubMed. Reference lists of retrieved articles were distributed to panel members before the meeting and updated during the meeting. Published case series and case reports of individuals with HS, published randomized controlled trials of relevant interventions used to treat nonirradiated individuals, reports of studies in irradiated animals, and prior recommendations of subject matter experts were selected. Studies were extracted using the Grading of Recommendations Assessment Development and Evaluation (GRADE) system. In cases in which data were limited or incomplete, a narrative review of the observations was made. No randomized controlled trials of medical countermeasures have been completed for individuals with radiation-associated HS. The use of GRADE analysis of countermeasures for injury to hematopoietic tissue was restricted by the lack of comparator groups in humans. Reliance on data generated in nonirradiated humans and experimental animals was necessary.Results:Based upon GRADE analysis and narrative review, a strong recommendation was made for the administration of granulocyte colony-stimulating factor or granulocyte macrophage colony-stimulating factor and a weak recommendation was made for the use of erythropoiesis-stimulating agents or hematopoietic stem cell transplantation.Conclusions:Assessment of therapeutic interventions for HS in humans exposed to nontherapeutic radiation is difficult because of the limits of the evidence.(Disaster Med Public Health Preparedness. 2011;5:202-212)

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Radiological outcomes in randomized controlled trials on biologic therapies for rheumatoid arthritis: a narrative review

Clinical Rheumatology ◽

10.1007/s10067-014-2504-7 ◽

2014 ◽

Vol 33 (7) ◽

pp. 877-884 ◽

Cited By ~ 3

Author(s):

E. Bizzi ◽

U. Massafra ◽

B. Laganà ◽

V. Bruzzese ◽

A. Picchianti Diamanti ◽

...

Keyword(s):

Rheumatoid Arthritis ◽

Randomized Controlled Trials ◽

Narrative Review ◽

Controlled Trials ◽

Biologic Therapies ◽

Randomized Controlled

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Comparison of the efficacy of a bougie and stylet in patients with endotracheal intubation: A meta-analysis of randomized controlled trials

Journal of Emergency Medicine ◽

10.1016/j.jemermed.2019.07.007 ◽

2019 ◽

Vol 57 (2) ◽

pp. 275-276

Author(s):

Seth Bartholomew ◽

Amanda Young

Keyword(s):

Randomized Controlled Trials ◽

Endotracheal Intubation ◽

Meta Analysis ◽

Controlled Trials ◽

Randomized Controlled

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Mid-Regional Pro-Adrenomedullin (MR-proADM) as a Biomarker for Sepsis and Septic Shock: Narrative Review

Healthcare ◽

10.3390/healthcare6030110 ◽

2018 ◽

Vol 6 (3) ◽

pp. 110 ◽

Cited By ~ 7

Author(s):

Uğur Önal ◽

Francisco Valenzuela-Sánchez ◽

Kalwaje Vandana ◽

Jordi Rello

Keyword(s):

Septic Shock ◽

Randomized Controlled Trials ◽

Organ Failure ◽

Narrative Review ◽

Cochrane Library ◽

Controlled Trials ◽

Randomized Controlled ◽

Diagnosis And Prognosis ◽

Sepsis And Septic Shock

Early identification and diagnosis of sepsis and septic shock is vitally important; despite appropriate management, mortality and morbidity rates remain high. For this reason, many biomarkers and screening systems have been investigated in accordance with the precision medicine concept. A narrative review was conducted to assess the role of mid-regional pro-adrenomedullin (MR-proADM) as a biomarker for sepsis and septic shock. Relevant studies were collected via an electronic PubMed, Web of Science, and The Cochrane Library search. The review focused on both diagnosis and prognosis in patients with sepsis and septic shock and specifically in subpopulations of patients with sepsis and septic shock with burns or malignant tumors. No exclusion criteria regarding age, sex, intensive care unit admission, follow-up duration, or co morbidities were used so as to maximize sensitivity and due to lack of randomized controlled trials, opinion paper and reviews were also included in this review. A total of 22 studies, one opinion paper, and one review paper were investigated. MR-proADM levels were found to be useful in assessing patients’ initial evolution and become even more useful during follow-up with increased area under curve values in the mortality prognosis by exceeding values of 0.8 in the data shown in several studies. These results also improve along with other biomarkers or severity scores and especially correlate with the organ failure degree. The results of this study indicate that MR-proADM is a good biomarker for the diagnosis and prognosis of sepsis and septic shock patients as well as for organ failure. Although several publications have discussed its role as a biomarker for pneumonia, its value as a biomarker for sepsis and septic shock should now be assessed in randomized controlled trials and more collaborative prospective studies with larger patient samples.

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