scholarly journals Colchicine Therapy and Plaque Stabilization in Patients With Acute Coronary Syndrome

2018 ◽  
Vol 11 (2) ◽  
pp. 305-316 ◽  
Author(s):  
Kaivan Vaidya ◽  
Clare Arnott ◽  
Gonzalo J. Martínez ◽  
Bernard Ng ◽  
Samuel McCormack ◽  
...  
Keyword(s):  
Acute Coronary Syndrome ◽  
Coronary Syndrome ◽  
Plaque Stabilization ◽  
Colchicine Therapy

scholarly journals Colchicine therapy in acute coronary syndrome patients acts on caspase-1 to suppress NLRP3 inflammasome monocyte activation

2016 ◽  
Vol 130 (14) ◽  
pp. 1237-1246 ◽  
Author(s):  
Stacy Robertson ◽  
Gonzalo J. Martínez ◽  
Cloe A. Payet ◽  
Jennifer Y. Barraclough ◽  
David S. Celermajer ◽  
...  
Keyword(s):  
Acute Coronary Syndrome ◽  
Gene Transcription ◽  
Nlrp3 Inflammasome ◽  
Healthy Subjects ◽  
Interleukin 1Β ◽  
Inflammasome Activation ◽  
Monocyte Activation ◽  
Coronary Syndrome ◽  
Caspase 1 ◽  
Colchicine Therapy

Inflammasome activation in monocytes is elevated in acute coronary syndrome (ACS) patients compared with healthy subjects. Acute colchicine therapy dramatically suppresses this activation, via inhibition of caspase-1 gene transcription leading to reduced secretion of interleukin-1β (IL-1β), supporting a beneficial role for colchicine in atherosclerosis.

Abstract #511: HS CRP in Acute Coronary Syndrome

2016 ◽  
Vol 22 ◽  
pp. 121-122
Author(s):  
Mukhyaprana Prabhu ◽  
Shyny Reddy ◽  
Ranjan Shetty ◽  
V.B. Mohan ◽  
Weena Stanley
Keyword(s):  
Acute Coronary Syndrome ◽  
Coronary Syndrome ◽  
Hs Crp
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