Low omega-3 fatty acid levels found in patients with acute coronary syndrome and depression

2009 ◽  
Keyword(s):  
Acute Coronary Syndrome ◽  
Fatty Acid ◽  
Omega 3 ◽  
Omega 3 Fatty Acid ◽  
Coronary Syndrome

scholarly journals Acute Coronary Syndrome Patients With Depression Have Low Blood Cell Membrane Omega-3 Fatty Acid Levels

2008 ◽  
Vol 70 (8) ◽  
pp. 856-862 ◽  
Author(s):  
Alpesh A. Amin ◽  
Rishi A. Menon ◽  
Kimberly J. Reid ◽  
William S. Harris ◽  
John A. Spertus
Keyword(s):  
Acute Coronary Syndrome ◽  
Fatty Acid ◽  
Cell Membrane ◽  
Blood Cell ◽  
Omega 3 ◽  
Omega 3 Fatty Acid ◽  
Coronary Syndrome

Abstract P414: Omega-3 Fatty Acids Modify the Genetic Risk of Early Onset Acute Coronary Syndrome

Circulation ◽  
2014 ◽  
Vol 129 (suppl_1) ◽  
Author(s):  
Sylvie S Leung Yinko ◽  
James C Engert ◽  
George Thanassoulis` ◽  
Ken D Stark ◽  
Meytal Avgil Tsadok ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Risk Score ◽  
Genetic Risk ◽  
Genetic Risk Score ◽  
Fatty Acid Intake ◽  
Omega 3 ◽  
Omega 3 Fatty Acid ◽  
Coronary Syndrome ◽  
Acid Intake ◽  
Gene Environment

Background: Recent gene-environment interaction studies suggest that diet may influence an individual’s genetic predisposition to cardiovascular risk. We tested the hypothesis that omega-3 fatty acid intake may influence the risk for acute coronary syndrome (ACS) conferred by genetic polymorphisms among patients with premature ACS. Methods: Our study population consisted of 706 patients of white European descent enrolled in GENESIS PRAXY, a multicentre prospective cohort study of patients aged 18 to 55 years hospitalized with ACS. We used a case-only design to investigate gene-environment interactions between the omega-3 index (a validated biomarker of omega-3 fatty acid intake) and 30 single nucleotide polymorphisms (SNPs) that have been robustly associated with ACS. We used logistic regression to study the associations between each SNP and the omega-3 index. Interaction was also assessed between the omega-3 index and a genetic risk score generated from the 30 SNPs as a simple unweighted count of the risk alleles for each SNP. All the SNPs used in the genetic risk score were uncorrelated (r2 <0.3). We further adjusted all models for age and sex. Results: The median age of our population was 49 years and 72.1% were male. Median omega-3 index was 3.35% (interquartile range 2.81-4.07%). None of the SNPs deviated from Hardy-Weinberg equilibrium. A synergistic multiplicative interaction for increased ACS risk was found between carriers of chromosome 9p21 variant rs4977574 and low omega-3 index (OR 1.57, 95% CI 1.07-2.32, p=0.02), but did not reach significance after correction for multiple testing. Similar results were obtained in the adjusted model (OR 1.55, 95% CI 1.05-2.29, p=0.03). We did not observe interaction between the genetic risk score and the omega-3 index. Conclusions: In conclusion, our results suggest that omega-3 fatty acid intake may modify the genetic risk conferred by chromosome 9p21 variation among ACS patients but require independent replication in other cohorts. Further validation research is also warranted to examine whether this interaction occurs in other ethnic groups.

A Consumer’s Guide to Eggs

EDIS ◽  
2013 ◽  
Vol 2013 (11) ◽  
Author(s):  
Jeanine Beatty ◽  
Karla Shelnutt ◽  
Gail P. A. Kauwell
Keyword(s):  
United States ◽  
Fatty Acid ◽  
New World ◽  
The United States ◽  
Omega 3 ◽  
Bottom Line ◽  
Christopher Columbus ◽  
Food Stores ◽  
Omega 3 Fatty Acid ◽  
Chicken Eggs

People have been eating eggs for centuries. Records as far back as 1400 BC show that the Chinese and Egyptians raised birds for their eggs. The first domesticated birds to reach the Americas arrived in 1493 on Christopher Columbus' second voyage to the New World. Most food stores in the United States offer many varieties of chicken eggs to choose from — white, brown, organic, cage free, vegetarian, omega-3 fatty acid enriched, and more. The bottom line is that buying eggs is not as simple as it used to be because more choices exist today. This 4-page fact sheet will help you understand the choices you have as a consumer, so you can determine which variety of egg suits you and your family best. Written by Jeanine Beatty, Karla Shelnutt, and Gail Kauwell, and published by the UF Department of Family Youth and Community Sciences, November 2013. http://edis.ifas.ufl.edu/fy1357

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