Tumour-associated urokinase-type plasminogen activator (uPA) and its inhibitor PAI-1 in normal and neoplastic tissues of patients with squamous cell cancer of the oral cavity – clinical relevance and prognostic value

2005 ◽  
Vol 33 (3) ◽  
pp. 191-196 ◽  
Author(s):  
Brigitte Hundsdorfer ◽  
Hans-Florian Zeilhofer ◽  
Klaus Peter Bock ◽  
Peer Dettmar ◽  
Manfred Schmitt ◽  
...  
Keyword(s):  
Oral Cavity ◽  
Plasminogen Activator ◽  
Squamous Cell ◽  
Clinical Relevance ◽  
Prognostic Value ◽  
Squamous Cell Cancer ◽  
Cell Cancer ◽  
Type Plasminogen Activator ◽  
Urokinase Type Plasminogen Activator ◽  
Pai 1

Localization of Fibrinolytic Activators and Inhibitors in Normal and Atherosclerotic Vessels

1996 ◽  
Vol 75 (06) ◽  
pp. 933-938 ◽  
Author(s):  
Marten Fålkenberg ◽  
Johan Tjärnstrom ◽  
Per Örtenwall ◽  
Michael Olausson ◽  
Bo Risberg
Keyword(s):  
Endothelial Cells ◽  
Plasminogen Activator ◽  
Plasminogen Activator Inhibitor ◽  
Vasa Vasorum ◽  
Type Plasminogen Activator ◽  
Urokinase Type Plasminogen Activator ◽  
Tissue Plasminogen ◽  
The Media ◽  
Activator Inhibitor ◽  
Pai 1

SummaryLocal fibrinolytic changes in atherosclerotic arteries have been suggested to influence plaque growth and promote mural thrombosis on ruptured or ulcerated plaques. Increased levels of plasminogen activator inhibitor (PAI-1) have been found in atherosclerotic arteries. In this study tissue plasminogen activator (t-PA), urokinase-type plasminogen activator (u-PA) and PAI-1 were localized in arterial biopsies of healthy and atherosclerotic vessels by immunohistochemis-try. The expression of fibrinolytic regulators was related to the distribution of endothelial cells (EC) and macrophages. Results: t-PA was expressed in vasa vasorum. PAI-1 was positive in endothelial cells, in the media and in the adventitia. Increased expression of t-PA, u-PA and PAI-1 was found in atherosclerotic vessels. t-PA, u-PA, PAI-1 and macrophages were co-localized in plaques. These results support the concept that macrophages can be important in the local regulation of fibrinolysis in atherosclerotic vessels.

Prognostic Value of Bilateral Positive Nodes in Squamous Cell Cancer of the Vulva

2009 ◽  
Vol 19 (7) ◽  
pp. 1276-1280 ◽  
Author(s):  
Guus Fons ◽  
Simon E. Hyde ◽  
Marrije R. Buist ◽  
Marten S. Schilthuis ◽  
Peter Grant ◽  
...  
Keyword(s):  
Squamous Cell ◽  
Prognostic Value ◽  
Squamous Cell Cancer ◽  
Cell Cancer
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