Near-infrared dye bound human serum albumin with separated imaging and therapy wavelength channels for imaging-guided photothermal therapy preventing tumor metastasis

Abstract A pleuroperitoneal communication is a serious complication for patients undergoing continuous ambulatory peritoneal dialysis (CAPD). Video-assisted thoracoscopic surgery is performed using indocyanine green adsorbed to human serum albumin fluorescence to identify the communication because human serum albumin reinforces fluorescence images. A patient diagnosed with a pleuroperitoneal communication was referred to our department and underwent surgery. To detect the communication, a dialysate mixture that contained indocyanine green and human serum albumin was injected from the CAPD catheter. Real-time fluorescence images were able to clearly show a bleb-like lesion with a near-infrared spectroscopy camera, and the site was repaired. The patient had no recurrence at one-year follow-up. This method might be good method for pleuroperitoneal communication surgery.

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Selective detection of human serum albumin by near infrared emissive fluorophores: Insights into structure-property relationship

Journal of Photochemistry and Photobiology A Chemistry ◽

10.1016/j.jphotochem.2019.02.038 ◽

2019 ◽

Vol 376 ◽

pp. 100-107 ◽

Cited By ~ 10

Author(s):

Rajib Choudhury ◽

Siddhi Rajeshbhai Patel ◽

Anindya Ghosh

Keyword(s):

Human Serum Albumin ◽

Serum Albumin ◽

Human Serum ◽

Near Infrared ◽

Selective Detection ◽

Structure Property ◽

Property Relationship ◽

Structure Property Relationship

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NIR organic dyes based on phenazine-cyanine for photoacoustic imaging-guided photothermal therapy

Journal of Materials Chemistry B ◽

10.1039/c8tb01750f ◽

2018 ◽

Vol 6 (45) ◽

pp. 7420-7426 ◽

Cited By ~ 13

Author(s):

Yongchao Yan ◽

Jiawen Chen ◽

Zhijuan Yang ◽

Xiao Zhang ◽

Zhuang Liu ◽

...

Keyword(s):

Human Serum Albumin ◽

Serum Albumin ◽

Human Serum ◽

Photothermal Therapy ◽

Organic Dyes ◽

Photoacoustic Imaging

Two NIR organic dyes based on phenazine-cyanine were successfully assembled with human serum albumin (HSA) forming appropriate size nanoparticles for photoacoustic imaging-guided photothermal therapy.

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Galactosyl Human Serum Albumin-NMP1 Conjugate: A Near Infrared (NIR)-Activatable Fluorescence Imaging Agent to Detect Peritoneal Ovarian Cancer Metastases

Bioconjugate Chemistry ◽

10.1021/bc3002419 ◽

2012 ◽

Vol 23 (8) ◽

pp. 1671-1679 ◽

Cited By ~ 46

Author(s):

Vinita M. Alexander ◽

Kohei Sano ◽

Zhanqian Yu ◽

Takahito Nakajima ◽

Peter L. Choyke ◽

...

Keyword(s):

Ovarian Cancer ◽

Human Serum Albumin ◽

Serum Albumin ◽

Human Serum ◽

Fluorescence Imaging ◽

Near Infrared ◽

Imaging Agent ◽

Cancer Metastases ◽

Galactosyl Human Serum Albumin

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Multifunctional human serum albumin-modified reduced graphene oxide for targeted photothermal therapy of hepatocellular carcinoma

RSC Advances ◽

10.1039/c5ra24785c ◽

2016 ◽

Vol 6 (14) ◽

pp. 11167-11175 ◽

Cited By ~ 4

Author(s):

Aixian Zheng ◽

Da Zhang ◽

Ming Wu ◽

Huanghao Yang ◽

Xiaolong Liu ◽

...

Keyword(s):

Hepatocellular Carcinoma ◽

Graphene Oxide ◽

Human Serum Albumin ◽

Serum Albumin ◽

Human Serum ◽

Reduced Graphene Oxide ◽

Photothermal Therapy ◽

Reduced Graphene ◽

Nir Laser ◽

Hcc Cells

Multifunctional human serum albumin-modified reduced graphene oxide can specifically target HCC cells and effectively kill them with the help of a NIR laser.

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