scholarly journals Immunoliposome-mediated drug delivery to Plasmodium -infected and non-infected red blood cells as a dual therapeutic/prophylactic antimalarial strategy

2015 ◽  
Vol 210 ◽  
pp. 217-229 ◽  
Author(s):  
Ernest Moles ◽  
Patricia Urbán ◽  
María Belén Jiménez-Díaz ◽  
Sara Viera-Morilla ◽  
Iñigo Angulo-Barturen ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Red Blood Cells ◽  
Blood Cells

Red Blood Cells as Advanced Drug Delivery Systems for Antiviral Nucleoside Analogues

1992 ◽  
pp. 239-245 ◽  
Author(s):  
Mauro Magnani ◽  
Luigia Rossi ◽  
Anna Casabianca ◽  
Alessandra Fraternale ◽  
Giuditta Schiavano ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Red Blood Cells ◽  
Blood Cells ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Nucleoside Analogues ◽  
Antiviral Nucleoside

scholarly journals Shear-Induced Encapsulation into Red Blood Cells: A New Microfluidic Approach to Drug Delivery

2019 ◽  
Vol 48 (1) ◽  
pp. 236-246 ◽  
Author(s):  
Monica Piergiovanni ◽  
Giustina Casagrande ◽  
Francesca Taverna ◽  
Ilaria Corridori ◽  
Marta Frigerio ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Red Blood Cells ◽  
Blood Cells

A MATHEMATICAL MODEL OF DRUG ADMINISTRATION BY PHAGOCYTOSIS OF LOADED ERYTHROCYTES

1995 ◽  
Vol 03 (02) ◽  
pp. 447-455
Author(s):  
FORTUNATA SOLIMANO
Keyword(s):  
Mathematical Model ◽  
Drug Delivery ◽  
Time Delay ◽  
Differential Equations ◽  
Red Blood Cells ◽  
Therapeutic Effect ◽  
Discrete Time ◽  
Blood Cells ◽  
Nonlinear Differential Equations ◽  
Discrete Time Delay

A mathematical model for the drug delivery to macrophages of the tissues by using a preassigned cohort of red blood cells loaded with a drug is presented. This model is a system of three nonlinear differential equations, with a discrete time delay and an input depending on the time. The input should be controlled in order to obtain the longest duration of the therapeutic effect.

Red Blood Cells for Drug Delivery

Small Methods ◽  
2017 ◽  
Vol 1 (12) ◽  
pp. 1700270 ◽  
Author(s):  
Junjie Yan ◽  
Jicheng Yu ◽  
Chao Wang ◽  
Zhen Gu
Keyword(s):  
Drug Delivery ◽  
Red Blood Cells ◽  
Blood Cells

scholarly journals Vascular Drug Delivery Using Carrier Red Blood Cells: Focus on RBC Surface Loading and Pharmacokinetics

Pharmaceutics ◽  
2020 ◽  
Vol 12 (5) ◽  
pp. 440 ◽  
Author(s):  
Patrick M. Glassman ◽  
Carlos H. Villa ◽  
Anvay Ukidve ◽  
Zongmin Zhao ◽  
Paige Smith ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Development ◽  
Red Blood Cells ◽  
Blood Cells ◽  
Drug Delivery Systems ◽  
Ex Vivo ◽  
Delivery Systems ◽  
Surface Loading ◽  
Intended Application

Red blood cells (RBC) have great potential as drug delivery systems, capable of producing unprecedented changes in pharmacokinetics, pharmacodynamics, and immunogenicity. Despite this great potential and nearly 50 years of research, it is only recently that RBC-mediated drug delivery has begun to move out of the academic lab and into industrial drug development. RBC loading with drugs can be performed in several ways—either via encapsulation within the RBC or surface coupling, and either ex vivo or in vivo—depending on the intended application. In this review, we briefly summarize currently used technologies for RBC loading/coupling with an eye on how pharmacokinetics is impacted. Additionally, we provide a detailed description of key ADME (absorption, distribution, metabolism, elimination) changes that would be expected for RBC-associated drugs and address unique features of RBC pharmacokinetics. As thorough understanding of pharmacokinetics is critical in successful translation to the clinic, we expect that this review will provide a jumping off point for further investigations into this area.

Drug Delivery through Phagocytosis of Red Blood Cells

2004 ◽  
Vol 31 (2) ◽  
pp. 92-101 ◽  
Author(s):  
S. Serafini ◽  
L. Rossi ◽  
A. Antonelli ◽  
A. Fraternale ◽  
A. Cerasi ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Red Blood Cells ◽  
Blood Cells

scholarly journals Drug delivery by red blood cells

IUBMB Life ◽  
2011 ◽  
Vol 63 (8) ◽  
pp. 621-631 ◽  
Author(s):  
Sara Biagiotti ◽  
Maria Filomena Paoletti ◽  
Alessandra Fraternale ◽  
Luigia Rossi ◽  
Mauro Magnani
Keyword(s):  
Drug Delivery ◽  
Red Blood Cells ◽  
Blood Cells
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