Advances in the strategies for designing receptor-targeted molecular imaging probes for cancer research

2019 ◽  
Vol 305 ◽  
pp. 1-17 ◽  
Author(s):  
Young Ji Ko ◽  
Woo Jun Kim ◽  
Kwangmeyung Kim ◽  
Ick Chan Kwon
Keyword(s):  
Cancer Research ◽  
Molecular Imaging ◽  
Molecular Imaging Probes ◽  
Imaging Probes ◽  
Targeted Molecular Imaging

scholarly journals Mitochondrial-Targeted Molecular Imaging in Cardiac Disease

2017 ◽  
Vol 2017 ◽  
pp. 1-11 ◽  
Author(s):  
Jinhui Li ◽  
Jing Lu ◽  
You Zhou
Keyword(s):  
Molecular Imaging ◽  
Cardiac Disease ◽  
Single Photon ◽  
Photon Emission ◽  
Emission Computed Tomography ◽  
Positron Emission ◽  
Molecular Imaging Probes ◽  
Imaging Probes ◽  
Targeted Molecular Imaging

The present study aimed to discuss the role of mitochondrion in cardiac function and disease. The mitochondrion plays a fundamental role in cellular processes ranging from metabolism to apoptosis. The mitochondrial-targeted molecular imaging could potentially illustrate changes in global and regional cardiac dysfunction. The collective changes that occur in mitochondrial-targeted molecular imaging probes have been widely explored and developed. As probes currently used in the preclinical setting still have a lot of shortcomings, the development of myocardial metabolic activity, viability, perfusion, and blood flow molecular imaging probes holds great potential for accurately evaluating the myocardial viability and functional reserve. The advantages of molecular imaging provide a perspective on investigating the mitochondrial function of the myocardium in vivo noninvasively and quantitatively. The molecular imaging tracers of single-photon emission computed tomography and positron emission tomography could give more detailed information on myocardial metabolism and restoration. In this study, series mitochondrial-targeted99mTc-,123I-, and18F-labeled tracers displayed broad applications because they could provide a direct link between mitochondrial dysfunction and cardiac disease.

CLIC1 antibody conjugated nanoscale contrast agent as a sensitive and targeted molecular imaging probe for gallbladder cancer diagnosis

RSC Advances ◽  
2016 ◽  
Vol 6 (29) ◽  
pp. 24104-24110 ◽  
Author(s):  
Wei Lu ◽  
Ning Wang ◽  
YanYan Chu ◽  
Linzhu Zhou ◽  
Maolan Li ◽  
...  
Keyword(s):  
Molecular Imaging ◽  
Contrast Agent ◽  
Contrast Agents ◽  
Gallbladder Cancer ◽  
Cancer Diagnosis ◽  
Imaging Probe ◽  
Molecular Imaging Probes ◽  
Imaging Probes ◽  
Molecular Imaging Probe ◽  
Targeted Molecular Imaging

CLIC1 antibody-conjugated nano-scale contrast agents exhibit a fast and sensitive detection of gallbladder tumors and may be used in the future as powerful targeted molecular imaging probes for gallbladder cancer diagnosis.

scholarly journals Fluorine-labeled Dasatinib Nanoformulations as Targeted Molecular Imaging Probes in a PDGFB-driven Murine Glioblastoma Model

Neoplasia ◽  
2012 ◽  
Vol 14 (12) ◽  
pp. 1132-IN8 ◽  
Author(s):  
Miriam Benezra ◽  
Dolores Hambardzumyan ◽  
Oula Penate-Medina ◽  
Darren R. Veach ◽  
Nagavarakishore Pillarsetty ◽  
...  
Keyword(s):  
Molecular Imaging ◽  
Molecular Imaging Probes ◽  
Imaging Probes ◽  
Targeted Molecular Imaging

scholarly journals 68Ga-Chelation and comparative evaluation of N,N′-bis-[2-hydroxy-5-(carboxyethyl)benzyl]ethylenediamine-N,N′-diacetic acid (HBED-CC) conjugated NGR and RGD peptides as tumor targeted molecular imaging probes

MedChemComm ◽  
2017 ◽  
Vol 8 (3) ◽  
pp. 673-679 ◽  
Author(s):  
Drishty Satpati ◽  
Rohit Sharma ◽  
Chandan Kumar ◽  
Haladhar Dev Sarma ◽  
Ashutosh Dash
Keyword(s):  
Molecular Imaging ◽  
Comparative Evaluation ◽  
Diacetic Acid ◽  
Rgd Peptides ◽  
Molecular Imaging Probes ◽  
Imaging Probes ◽  
Targeted Molecular Imaging

Radiosynthesis and bioevaluation of HBED-CC conjugated RGD and NGR peptides, 68Ga-HBED-CC-c(NGR) and 68Ga-HBED-CC-c(RGD) is described.

Functional MOFs as molecular imaging probes and theranostics

2020 ◽  
pp. 425-443
Author(s):  
Rajasekharreddy Pala ◽  
Subhaswaraj Pattnaik ◽  
Yun Zeng ◽  
Siddhardha Busi ◽  
Surya M. Nauli ◽  
...  
Keyword(s):  
Molecular Imaging ◽  
Molecular Imaging Probes ◽  
Imaging Probes

scholarly journals Techniques for Molecular Imaging Probe Design

2011 ◽  
Vol 10 (6) ◽  
pp. 7290.2011.00003 ◽  
Author(s):  
Fred Reynolds ◽  
Kimberly A. Kelly
Keyword(s):  
Molecular Imaging ◽  
Target Selection ◽  
Relevant Information ◽  
Probe Design ◽  
Imaging Probe ◽  
Molecular Imaging Probes ◽  
Genomics And Proteomics ◽  
Imaging Probes ◽  
Molecular Imaging Probe ◽  
Underlying Mechanisms

Molecular imaging allows clinicians to visualize disease-specific molecules, thereby providing relevant information in the diagnosis and treatment of patients. With advances in genomics and proteomics and underlying mechanisms of disease pathology, the number of targets identified has significantly outpaced the number of developed molecular imaging probes. There has been a concerted effort to bridge this gap with multidisciplinary efforts in chemistry, proteomics, physics, material science, and biology—all essential to progress in molecular imaging probe development. In this review, we discuss target selection, screening techniques, and probe optimization with the aim of developing clinically relevant molecularly targeted imaging agents.

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