Construction of Novel Nanohybrids(Fe3O4/HAp/Au) With Multifunctional Structure for Efficient Photocatalytic Application

The controlled synthesis of nanohybrids with magnetic metal oxides (Fe3O4), noble metals Au, and hydroxyapatite (HAp, hydroxyapatite) have received considerable attention for applications in photocatalysis, molecular imaging, drug delivery. Green and multifunctional Fe3O4/HAp/Au composite nanoparticles (NPs) with biocompatibility and magnetism for photocatalyst was developed by a facile method. The overall architecture of nanocomposites is one of the most important factors dictating the physical and chemical properties of nanohybrids with significant advances and various functions. The improvement performance of the Fe3O4/HAp/Au in photocatalysis was evaluated by degradation of organic pollutant (methylene blue, MB) under visible light irradiation. The results showed that the hybrid Fe3O4/HAp/Au NP displayed high photocatalytic activity due to surface plasmon resonance (SPR) of Au, the combination of magnetic NPs and HAps with adsorption, also the mechanism was discussed in detail. The efficient magnetic composite nanoparticles can be separated with target and recover, as well as recycle processes. It proposed novel NPs and methodology to design and fabrication of multifunctional NPs with high quality for application of photocatalysis. Furthermore, it is expected that the safe, green and multifunctional composite NPs will provide an interesting platform not only for photocatalysis, but also for developing molecular imaging probe and drug delivery with target, as well as Raman detection.

Peptide-Conjugated Phosphorodiamidate Morpholino Oligomers for In Situ Live-Cell Molecular Imaging of Dengue Virus Replication

Current methods to detect and monitor pathogens in biological systems are largely limited by the tradeoffs between spatial context and temporal detail. A new generation of molecular tracking that provides both information simultaneously involves in situ detection coupled with non-invasive imaging. An example is antisense imaging that uses antisense oligonucleotide probes complementary to a target nucleotide sequence. In this study, we explored the potential of repurposing antisense oligonucleotides initially developed as antiviral therapeutics as molecular probes for imaging of viral infections in vitro and in vivo. We employed nuclease-resistant phosphorodiamidate synthetic oligonucleotides conjugated with cell-penetrating peptides (i.e., PPMOs) previously established as antivirals for dengue virus serotype-2 (DENV2). As proof of concept, and before further development for preclinical testing, we evaluated its validity as in situ molecular imaging probe for tracking cellular DENV2 infection using live-cell fluorescence imaging. Although the PPMO was designed to specifically target the DENV2 genome, it was unsuitable as in situ molecular imaging probe. This study details our evaluation of the PPMOs to assess specific and sensitive molecular imaging of DENV2 infection and tells a cautionary tale for those exploring antisense oligonucleotides as probes for non-invasive imaging and monitoring of pathogen infections in experimental animal models.

A fluorescent molecular imaging probe with selectivity for soluble tau aggregated protein

pTP-TFE imaging probe can distinguish soluble tau aggregated proteins from other aggregated proteins enabling earlier detection of neurodegenerative diseases.

Functionalization of NaGdF4 nanoparticles with a dibromomaleimide-terminated polymer for MR/optical imaging of thrombosis

A thrombosis-targeted molecular imaging probe with magnetic resonance (MR) and optical dual-modality capacity using dibromomaleimide (DBM)-bearing polymer-grafted NaGdF4 nanoparticles.