Self-assembled peptide nanoparticles responsive to multiple tumor microenvironment triggers provide highly efficient targeted delivery and release of antitumor drug

2019 ◽  
Vol 316 ◽  
pp. 196-207 ◽  
Author(s):  
Xinglu Jiang ◽  
Xiaobo Fan ◽  
Wei Xu ◽  
Chenggui Zhao ◽  
Hailu Wu ◽  
...  
Keyword(s):  
Tumor Microenvironment ◽  
Targeted Delivery ◽  
Antitumor Drug ◽  
Multiple Tumor ◽  
Highly Efficient ◽  
Peptide Nanoparticles ◽  
Self Assembled

Self-assembled peptide nanoparticles as tumor microenvironment activatable probes for tumor targeting and imaging

2014 ◽  
Vol 177 ◽  
pp. 11-19 ◽  
Author(s):  
Ying Zhao ◽  
Tianjiao Ji ◽  
Hai Wang ◽  
Suping Li ◽  
Yuliang Zhao ◽  
...  
Keyword(s):  
Tumor Microenvironment ◽  
Tumor Targeting ◽  
Peptide Nanoparticles ◽  
Self Assembled

Targeted Delivery of Dual Anticancer Drugs Based on Self-Assembled iRGD-Modified Soluble Drug–Polymer Pattern Conjugate Nanoparticles

2021 ◽  
Vol 4 (2) ◽  
pp. 1499-1507
Author(s):  
Chunxiao Li ◽  
Zhenyu Chen ◽  
Dan Zheng ◽  
Jingyang Zhao ◽  
Jiandu Lei
Keyword(s):  
Anticancer Drugs ◽  
Targeted Delivery ◽  
Self Assembled

Self-assembled peptide and protein nanostructures for anti-cancer therapy: Targeted delivery, stimuli-responsive devices and immunotherapy

Nano Today ◽  
2021 ◽  
Vol 38 ◽  
pp. 101119
Author(s):  
Masoud Delfi ◽  
Rossella Sartorius ◽  
Milad Ashrafizadeh ◽  
Esmaeel Sharifi ◽  
Yapei Zhang ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Targeted Delivery ◽  
Stimuli Responsive ◽  
Anti Cancer ◽  
Self Assembled

3D self-assembled VS4 microspheres with high pseudocapacitance as highly efficient anodes for Na-ion batteries

Nanoscale ◽  
2018 ◽  
Vol 10 (46) ◽  
pp. 21671-21680 ◽  
Author(s):  
Wenbin Li ◽  
Jianfeng Huang ◽  
Liangliang Feng ◽  
Liyun Cao ◽  
Shuwei He
Keyword(s):  
Active Sites ◽  
High Capacity ◽  
Rate Capability ◽  
High Rate ◽  
High Rate Capability ◽  
Highly Efficient ◽  
Pseudocapacitive Behavior ◽  
Surface Active ◽  
Self Assembled ◽  
Cycling Life

The decreasing crystallinity of VS4 microspheres greatly increases the surface active sites, and then promotes the pseudocapacitive behavior, and finally leads to the high capacity, long cycling life and high rate capability.

scholarly journals Highly efficient and tumor-selective nanoparticles for dual-targeted immunogene therapy against cancer

2020 ◽  
Vol 6 (3) ◽  
pp. eaax5032 ◽  
Author(s):  
Kuan-Wei Huang ◽  
Fu-Fei Hsu ◽  
Jiantai Timothy Qiu ◽  
Guann-Jen Chern ◽  
Yi-An Lee ◽  
...  
Keyword(s):  
Tumor Microenvironment ◽  
Cancer Immunotherapy ◽  
Plasmid Dna ◽  
Systemic Toxicity ◽  
Great Promise ◽  
Anticancer Efficacy ◽  
Highly Efficient ◽  
Immunogene Therapy ◽  
Immunosuppressive Tumor Microenvironment ◽  
Tumor Selective

While immunotherapy holds great promise for combating cancer, the limited efficacy due to an immunosuppressive tumor microenvironment and systemic toxicity hinder the broader application of cancer immunotherapy. Here, we report a combinatorial immunotherapy approach that uses a highly efficient and tumor-selective gene carrier to improve anticancer efficacy and circumvent the systemic toxicity. In this study, we engineered tumor-targeted lipid-dendrimer-calcium-phosphate (TT-LDCP) nanoparticles (NPs) with thymine-functionalized dendrimers that exhibit not only enhanced gene delivery capacity but also immune adjuvant properties by activating the stimulator of interferon genes (STING)–cGAS pathway. TT-LDCP NPs delivered siRNA against immune checkpoint ligand PD-L1 and immunostimulatory IL-2–encoding plasmid DNA to hepatocellular carcinoma (HCC), increased tumoral infiltration and activation of CD8+ T cells, augmented the efficacy of cancer vaccine immunotherapy, and suppressed HCC progression. Our work presents nanotechnology-enabled dual delivery of siRNA and plasmid DNA that selectively targets and reprograms the immunosuppressive tumor microenvironment to improve cancer immunotherapy.

scholarly journals Multivalent Self-Assembled DNA Polymer for Tumor-Targeted Delivery and Live Cell Imaging of Telomerase Activity

2018 ◽  
Vol 90 (22) ◽  
pp. 13188-13192 ◽  
Author(s):  
Xueli Zhu ◽  
Hongyan Ye ◽  
Jin-Wen Liu ◽  
Ru-Qin Yu ◽  
Jian-Hui Jiang
Keyword(s):  
Targeted Delivery ◽  
Live Cell Imaging ◽  
Cell Imaging ◽  
Telomerase Activity ◽  
Live Cell ◽  
Self Assembled
Sign in / Sign up

Export Citation Format

Share Document