scholarly journals The role of Platelet Rich Plasma and other orthobiologics in bone healing and fracture management: A systematic review

2022 ◽  
pp. 101759
Author(s):  
M.S. Jamal ◽  
E.T. Hurley ◽  
H. Asad ◽  
A. Asad ◽  
T. Taneja
Keyword(s):  
Systematic Review ◽  
Bone Healing ◽  
Platelet Rich Plasma ◽  
Fracture Management

The Role of Platelet-Rich Plasma in Arthroscopic Rotator Cuff Repair: A Systematic Review With Quantitative Synthesis

2012 ◽  
Vol 28 (11) ◽  
pp. 1718-1727 ◽  
Author(s):  
Jaskarndip Chahal ◽  
Geoffrey S. Van Thiel ◽  
Nathan Mall ◽  
Wendell Heard ◽  
Bernard R. Bach ◽  
...  
Keyword(s):  
Systematic Review ◽  
Rotator Cuff ◽  
Rotator Cuff Repair ◽  
Platelet Rich Plasma ◽  
Arthroscopic Rotator Cuff Repair ◽  
Quantitative Synthesis ◽  
Arthroscopic Rotator Cuff ◽  
Cuff Repair

scholarly journals The Role of Recombinant Parathormone derivative in Bone healing. Making the Unfavorable, Favorable - A Systematic Review

2020 ◽  
Vol 12 (6s) ◽  
pp. 1753-1768
Author(s):  
S Swarna Meenakshi ◽  
Sheeja S Varghese
Keyword(s):  
Systematic Review ◽  
Bone Healing

Fracture vascularity and bone healing: A systematic review of the role of VEGF

Injury ◽  
2008 ◽  
Vol 39 ◽  
pp. S45-S57 ◽  
Author(s):  
N.C. Keramaris ◽  
G.M. Calori ◽  
V.S. Nikolaou ◽  
E.H. Schemitsch ◽  
P.V. Giannoudis
Keyword(s):  
Systematic Review ◽  
Bone Healing

The Role of Platelet-Rich Plasma in Cartilage Pathology: An Updated Systematic Review of the Basic Science Evidence

2019 ◽  
Vol 35 (3) ◽  
pp. 961-976.e3 ◽  
Author(s):  
Michael P. Fice ◽  
J. Chance Miller ◽  
Robert Christian ◽  
Charles P. Hannon ◽  
Niall Smyth ◽  
...  
Keyword(s):  
Systematic Review ◽  
Basic Science ◽  
Platelet Rich Plasma ◽  
Science Evidence

The clinical use of platelet-rich plasma in the promotion of bone healing: A systematic review

Injury ◽  
2009 ◽  
Vol 40 (2) ◽  
pp. 158-162 ◽  
Author(s):  
X.L. Griffin ◽  
C.M. Smith ◽  
M.L. Costa
Keyword(s):  
Systematic Review ◽  
Bone Healing ◽  
Platelet Rich Plasma ◽  
Clinical Use

scholarly journals The role of peptides in bone healing and regeneration: a systematic review

BMC Medicine ◽  
2016 ◽  
Vol 14 (1) ◽  
Author(s):  
Ippokratis Pountos ◽  
Michalis Panteli ◽  
Anastasios Lampropoulos ◽  
Elena Jones ◽  
Giorgio Maria Calori ◽  
...  
Keyword(s):  
Systematic Review ◽  
Bone Healing

Predictive role of perioperative platelet count on posthepatectomy liver failure and mortality: a systematic review and meta-analysis

2018 ◽  
Vol 56 (01) ◽  
pp. E2-E89
Author(s):  
M Golriz ◽  
O Ghamarnejad ◽  
E Khajeh ◽  
K Hoffmann ◽  
A Mehrabi
Keyword(s):  
Systematic Review ◽  
Platelet Count ◽  
Liver Failure ◽  
Meta Analysis ◽  
Posthepatectomy Liver Failure ◽  
Predictive Role

Haemostatic Platelet Plug Formation in the Isolated Rabbit Mesenteric Preparation - An Analysis of Red Blood Cell Participation

1980 ◽  
Vol 44 (01) ◽  
pp. 006-008 ◽  
Author(s):  
D Bergqvist ◽  
K-E Arfors
Keyword(s):  
Whole Blood ◽  
Platelet Rich Plasma ◽  
Adenosine Diphosphate ◽  
In Vitro Test ◽  
Pharmacological Agents ◽  
Vitro Test ◽  
Releasing Effect ◽  
Plug Formation

SummaryIn a model using an isolated rabbit mesenteric preparation microvessels were transected and the time until haemostatic plugs formed was registered. Perfusion of platelet rich plasma gave no haemostasis whereas whole blood did. Addition of chlorpromazine or adenosine to the whole blood significantly prolonged the time for haemostasis, and addition of ADP to the platelet rich plasma significantly shortened it. It is concluded that red cells are necessary for a normal haemostasis in this model, probably by a combination of a haemodynamic and ADP releasing effect.The fundamental role of platelets in haemostatic plug formation is unquestionable but there are still problems concerning the stimulus for this process to start. Three platelet aggregating substances have been discussed – thrombin, adenosine diphosphate (ADP) and collagen. Evidence speaking in favour of thrombin is, however, very minimal, and the discussion has to be focused on collagen and ADP. In an in vitro system using polyethylene tubings we have shown that "haemostasis" can be obtained without the presence of collagen but against these results can be argued that it is only another in vitro test for platelet aggregation (1).To be able to induce haemostasis in this model, however, the presence of red blood cells is necessary. To further study this problem we have developed a model where haemostatic plug formation can be studied in the isolated rabbit mesentery and we have briefly reported on this (2).Thus, it is possible to perfuse the vessels with whole blood as well as with platelet rich plasma (PRP) and different pharmacological agents of importance.

Testosterone Potentiation of Ionophore and ADP Induced Platelet Aggregation : Relationship to Arachidonic Acid Metabolism

1981 ◽  
Vol 46 (02) ◽  
pp. 538-542 ◽  
Author(s):  
R Pilo ◽  
D Aharony ◽  
A Raz
Keyword(s):  
Arachidonic Acid ◽  
Platelet Aggregation ◽  
Unsaturated Fatty Acids ◽  
Human Platelet ◽  
Platelet Rich Plasma ◽  
Arachidonic Acid Metabolism ◽  
Ionophore A23187 ◽  
Low Concentrations ◽  
Induced Aggregation

SummaryThe role of arachidonic acid oxygenated products in human platelet aggregation induced by the ionophore A23187 was investigated. The ionophore produced an increased release of both saturated and unsaturated fatty acids and a concomitant increased formation of TxA2 and other arachidonate products. TxA2 (and possibly other cyclo oxygenase products) appears to have a significant role in ionophore-induced aggregation only when low concentrations (<1 μM) of the ionophore are employed.Testosterone added to rat or human platelet-rich plasma (PRP) was shown previously to potentiate platelet aggregation induced by ADP, adrenaline, collagen and arachidonic acid (1, 2). We show that testosterone also potentiates ionophore induced aggregation in washed platelets and in PRP. This potentiation was dose and time dependent and resulted from increased lipolysis and concomitant generation of TxA2 and other prostaglandin products. The testosterone potentiating effect was abolished by preincubation of the platelets with indomethacin.

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