Effect of a hyaluronic acid and carboxymethylcellulose ophthalmic solution on ocular comfort and tear-film instability after cataract surgery

2015 ◽  
Vol 41 (8) ◽  
pp. 1699-1704 ◽  
Author(s):  
Rita Mencucci ◽  
Carlotta Boccalini ◽  
Roberto Caputo ◽  
Eleonora Favuzza
Keyword(s):  
Hyaluronic Acid ◽  
Cataract Surgery ◽  
Tear Film ◽  
Ophthalmic Solution ◽  
Film Instability ◽  
Ocular Comfort

scholarly journals Efficacy of carbomer sodium hyaluronate trehalose vs hyaluronic acid to improve tear film instability and ocular surface discomfort after cataract surgery

2019 ◽  
Vol Volume 13 ◽  
pp. 1157-1163 ◽  
Author(s):  
L Caretti ◽  
A La Gloria Valerio ◽  
R Piermarocchi ◽  
G Badin ◽  
G Verzola ◽  
...  
Keyword(s):  
Hyaluronic Acid ◽  
Cataract Surgery ◽  
Ocular Surface ◽  
Sodium Hyaluronate ◽  
Tear Film ◽  
Film Instability

scholarly journals Evaluation of protection against desiccation with different artificial tears containing 0.1%-0.3% hyaluronic acid in experimental dry eye model

2020 ◽  
Author(s):  
Fatma Ahmed ◽  
Frank Tost ◽  
Rico Großjohann ◽  
Carmen Wolke ◽  
Uwe Lendeckel
Keyword(s):  
Hyaluronic Acid ◽  
Cell Line ◽  
Dry Eye ◽  
Exposure Time ◽  
Ionic Composition ◽  
Sodium Hyaluronate ◽  
Tear Film ◽  
Epithelial Cell Line ◽  
Film Instability

Abstract Background: Tear film instability, hyperosmolarity, ocular surface inflammation, apoptosis and neuro-sensory abnormalities are causes of dry eye. Lubricant target tear film instability, the most effective agent for tear film stabilization being Sodium Hyaluronate 0.1 -0.3%. Sodium Hyaluronate is suggested to be protective for epithelium in dry eye. To test this hypothesis, this study was performed in vitro with commercially available solutions containing hyaluronic acid (HA) in concentrations ranging from 0.1 to 0.3%. To evaluate the desiccation protection capability of different Sodium Hyaluronate 0.1 to 0.3%, we employed a reproducible in vitro cell culture system. Methods: Conjunctival (Chang 1-5c-4) and corneal cells (pRSV-T 2.040) were cultivated under standard conditions. Under confluent cell growth cells, conjunctival epithelial cell line Chang 1-5c-4 and the corneal cell line 2.040 pRSV-T were wetted for 20 min with five commercial ophthalmic solutions and one agent in trial phase (sample 1: 0.1% HA; sample 2: 0.3% HA; sample 3: 0.15% HA, 2% dexpanthenol, sodium chloride; sample 4: 0.1% HA; sample 5: 0.2% HA; sample 6: unknown, PBS as negative control, unsupplemented medium as positive control). After 20 minutes cells were exposed to continuous air flow for 0, 15, 30 and 45 minutes. Assessment of viable cells was performed by alamarBlue® assay and LIVE/DEAD® Viability/ Cytotoxicity Kit. Results: It has been shown that both cell lines showed different response to protection by the tested solutions. Greatest protection was observed at 15 minutes with most agents. Best results in protection from desiccation was assessed with sample 2 even at maximum exposure time at 45 minutes. Sample 2 showed an average survival rate of 91% at 45 minutes exposure time, whereas no significant amount of vital cells were detected after application with sample 6. Sample 6 was the only substance that presented with early significant cell loss at 0 and 15 minutes by 35%. Conclusions: Higher concentration of Hyaluronate acid with 0.3% and an ionic composition close to the normal tearfluid seem to provide the best protective effect against desiccation in experimental dry eye.

scholarly journals Hyaluronic Acid/Trehalose Ophthalmic Solution in Reducing Post-Cataract Surgery Dry Eye Signs and Symptoms: A Prospective, Interventional, Randomized, Open-Label Study

2021 ◽  
Vol 10 (20) ◽  
pp. 4699
Author(s):  
Rita Mencucci ◽  
Eleonora Favuzza ◽  
Giulia Decandia ◽  
Michela Cennamo ◽  
Fabrizio Giansanti
Keyword(s):  
Hyaluronic Acid ◽  
Cataract Surgery ◽  
Dry Eye ◽  
Ophthalmic Solution ◽  
Signs And Symptoms ◽  
Ocular Surface Disease Index ◽  
Open Label ◽  
Open Label Study ◽  
Group A ◽  
Group B

The purpose of this prospective study was to evaluate the efficacy of the perioperative use of a hyaluronic acid (HA) and trehalose ophthalmic solution (Thealoz® Duo) in reducing post-cataract surgery dry eye signs and symptoms in patients with mild/moderate dry eye disease (DED). One hundred and twenty patients, scheduled for unilateral cataract surgery, were randomized into three groups: (1) group A: HA/trehalose three times/day in the preoperative week and for 5 postoperative weeks; (2) group B: HA/trehalose for only 5 postoperative weeks; (3) group C: no artificial tears. In groups A and B, OSDI (Ocular Surface Disease Index) questionnaire scores were significantly lower than group C at all the postoperative visits; in group A they were significantly lower than group B on the day of surgery, with similar results in the first and fifth weeks after surgery. In groups A and B, break-up time (BUT) was significantly higher than group C during the postoperative period (p ≤ 0.001). In comparison to the preoperative values, BUT in group A remained stable 7 days after surgery; however, in groups B and C, it significantly decreased. In conclusion, the HA/trehalose ophthalmic solution effectively reduced post-cataract surgery DED signs and symptoms in patients with mild/moderate DED, particularly if also administered in the preoperative period.

scholarly journals Effect of diquafosol three per cent ophthalmic solution on tear film and corneal aberrations after cataract surgery

2017 ◽  
Vol 100 (6) ◽  
pp. 590-594 ◽  
Author(s):  
Hun Lee ◽  
Sang Myung Kim ◽  
Seonghee Choi ◽  
Kyoung Yul Seo ◽  
Eung Kweon Kim ◽  
...  
Keyword(s):  
Cataract Surgery ◽  
Tear Film ◽  
Ophthalmic Solution ◽  
Corneal Aberrations

scholarly journals Protecting the Ocular Surface in Cataract Surgery: The Efficacy of the Perioperative Use of a Hydroxypropyl Guar and Hyaluronic Acid Ophthalmic Solution

2020 ◽  
Vol Volume 14 ◽  
pp. 1769-1775
Author(s):  
Eleonora Favuzza ◽  
Michela Cennamo ◽  
Lidia Vicchio ◽  
Fabrizio Giansanti ◽  
Rita Mencucci
Keyword(s):  
Hyaluronic Acid ◽  
Cataract Surgery ◽  
Ocular Surface ◽  
Ophthalmic Solution ◽  
Hydroxypropyl Guar

Post-Operative Evaluation of Tear Film Instability After Cataract Surgery

2021 ◽  
Vol 1 (1) ◽  
Author(s):  
Asma Batool
Keyword(s):  
Cataract Surgery ◽  
Teaching Hospital ◽  
Tear Film ◽  
Sampling Technique ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Film Stability ◽  
Mean Values ◽  
Film Instability ◽  
Break Up

Purpose of Study: To evaluate tear film instability after cataract surgery by measuring tear break up time. Place of Study: This study was carried out in Teaching Hospital, University of Lahore, Lahore, Pakistan. Materials and Methods: A descriptive cross- sectional study was conducted in Teaching Hospital, UOL. Tear break up time was measured on patients post-operatively who under -went cataract surgery. A total of 60 patients were included in study after non –probability convenient sampling technique. Both male and female patients were included in study age 45-65 years. Data was collected through self-designed questionnaire based proforma. Further results were analyzed using SPSS version 20. Results: Tear break up time was found statistically reduced at 1 week, 2 week and after one month postoperatively(P =.0002, P<.0001). However, the tear film stability had reverted to approximately the preoperative measurement 1 month after surgery. The mean values of postoperative results were altered from preoperative measurement values. BUT outcomes had reduced considerably at 1 week postoperatively (P=.0001) but had resumed to very nearly the preoperative value 1 month after of cataract surgery. While goblet cell density (GCD) had reduced considerably at 1 week, 2 weekand 1 month postoperatively (P<.0001). Conclusion: This study concludes that tear breakup time is significantly reduced after cataract surgery due to destruction of goblet cells as shown in above tables. But tear break up time is significantly improved after one week, two weeks and one month of follow ups respectively

scholarly journals The Complications of Cataract Surgery in Patients with Pseudoexfoliation

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Tatjana Sarenac Vulovic ◽  
Dusan Todorovic ◽  
Nenad Petrovic ◽  
Svetlana Jovanovic
Keyword(s):  
Intraocular Pressure ◽  
Cataract Surgery ◽  
Tear Film ◽  
Corneal Edema ◽  
Crystalline Lens ◽  
Mean Value ◽  
Control Group ◽  
Film Instability ◽  
Age Related ◽  
Anterior Lens Capsule

Abstract The senile cataract represents the blurring of the crystalline lens after the age of 65. It occurs due to metabolic changes in the crystalline lens which occur over the years. The only effective way to treat cataract is the surgical one. Pseudoexfoliation is an age related systemic disorder. PEX represents the accumulation fibrillar material in the extracellular matrix of the tissue. The most known ocular manifestation of the PEX are the collection at iris pupillary margin and anterior lens capsule. This accumulation is associated with many intraoperative and postoperative complications in patients scheduled for cataract surgery. The aim of the study was to investigate the prevalence of the surgical complications during phacoemulsfication in patients with PEX. The study included 91 patients scheduled for cataract surgery divided into two groups (PEX group 46, control group 45 patients). Poor intraoperative midryasis, zonular dehiscence, postoperative corneal edema, anterior chamber inflammation, elevated intraocular pressure and tear film instability had particularly higher rate of occurring in PEX group comparing to the control group (p<0.001). The highest mean value of intraocular pressure was observed in PEX group on the first postoperative day 25.6 ± 1.1 mmHg, while the best corrected visual acuity was measured in control group 0.71 ± 1.2 one month after phacoemulsification. Cataract surgery in patients with PEX carries great risk, but with adequate preoperative planning, the awareness of the potential complications, can provide safe and routine phacoemulification in these patients.

scholarly journals Comparable effects on tear film parameters after femtosecond laser-assisted and conventional cataract surgery

2020 ◽  
Vol 40 (11) ◽  
pp. 3097-3104 ◽  
Author(s):  
Marc Schargus ◽  
Svetlana Ivanova ◽  
Gesa Stute ◽  
H. Burkhard Dick ◽  
Stephanie C. Joachim
Keyword(s):  
Femtosecond Laser ◽  
Cataract Surgery ◽  
Dry Eye ◽  
Surgical Techniques ◽  
Tear Film ◽  
Schirmer Test ◽  
Fluorescein Staining ◽  
Significant Difference ◽  
Eye Symptoms ◽  
Dry Eye Symptoms

Abstract Purpose Dry eye symptoms after conventional cataract surgery are a very common problem. Until now, only few data are available on objective tear film parameters in regard to femtosecond laser-assisted cataract surgery (LCS). Aim of this study was therefore to analyze and compare tear film parameter changes between LCS and conventional cataract surgery. Methods A consecutive group of 34 patients, scheduled for cataract surgery, were randomly selected for either LCS or conventional cataract surgery (17 patients/group). Tear film assessments including tear film osmolarity, Schirmer test, MMP-9 analysis via quantitative ELISA, corneal sensitivity, corneal fluorescein staining, and conjunctival fluorescein staining were sequentially evaluated pre- as well as 1 and 3 months postoperatively. Results Both groups showed no significant difference in baseline characteristics. All surgeries were performed without any complications. After 1 and 3 months, there was no statistically significant difference in regard to tear film osmolarity (1 month: p = 0.81, 3 months: p = 1.0), Schirmer test (1 month: p = 0.35, 3 month: p = 0.08), and MMP-9 concentration (1 month: p = 0.36, 3 month: p = 0.28) between the two groups. Conclusions Neither LCS nor conventional cataract surgery affected objective tear film parameters significantly during our 3-month postoperative observation period. Hence, both surgical techniques can be equally used to treat patients without prior dry eye symptoms.

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