scholarly journals Cervical human papillomavirus DNA detection in women living with HIV and HIV-uninfected women living in Limbe, Cameroon

2020 ◽  
Vol 128 ◽  
pp. 104445 ◽  
Author(s):  
Adebola Adedimeji ◽  
Rogers Ajeh ◽  
Anastase Dzudie ◽  
Ernestine Kendowo ◽  
Norbert Fuhngwa ◽  
...  
Keyword(s):  
Human Papillomavirus ◽  
Dna Detection ◽  
Women Living With Hiv ◽  
Living With Hiv ◽  
Cervical Human Papillomavirus ◽  
Papillomavirus Dna

Correlation of Cervical Cytology and Human Papillomavirus DNA Detection in Postmenopausal Women

1992 ◽  
Vol 11 (3) ◽  
pp. 204-209 ◽  
Author(s):  
Fraser Symmans ◽  
Leslie Mechanic ◽  
Phyllis MacConnell ◽  
Kathleen DaSilva ◽  
Barbara Stricker ◽  
...  
Keyword(s):  
Human Papillomavirus ◽  
Postmenopausal Women ◽  
Dna Detection ◽  
Cervical Cytology ◽  
Papillomavirus Dna

Comparison of three human papillomavirus DNA detection methods: Next generation sequencing, multiplex-PCR and nested-PCR followed by Sanger based sequencing

2015 ◽  
Vol 88 (5) ◽  
pp. 888-894 ◽  
Author(s):  
Allex Jardim da Fonseca ◽  
Renata Silva Galvão ◽  
Angelica Espinosa Miranda ◽  
Luiz Carlos de Lima Ferreira ◽  
Zigui Chen
Keyword(s):  
Human Papillomavirus ◽  
Next Generation Sequencing ◽  
Multiplex Pcr ◽  
Nested Pcr ◽  
Dna Detection ◽  
Detection Methods ◽  
Next Generation ◽  
Papillomavirus Dna ◽  
Generation Sequencing

scholarly journals Anogenital human papillomavirus virus DNA and sustained response to the quadrivalent HPV vaccine in women living with HIV-1

2018 ◽  
Vol 6 ◽  
pp. 15-21 ◽  
Author(s):  
Michelle S. Cespedes ◽  
Minhee Kang ◽  
Erna Milunka Kojic ◽  
Triin Umbleja ◽  
Catherine Godfrey ◽  
...  
Keyword(s):  
Human Papillomavirus ◽  
Hpv Vaccine ◽  
Sustained Response ◽  
Women Living With Hiv ◽  
Quadrivalent Hpv Vaccine ◽  
Living With Hiv ◽  
Hiv 1

Human papillomavirus infection and associated factors for cervical intraepithelial neoplasia in women living with HIV in China: a cross-sectional study

2018 ◽  
Vol 95 (2) ◽  
pp. 140-144 ◽  
Author(s):  
Qian Wang ◽  
Xiaomeng Ma ◽  
Xiaosong Zhang ◽  
Jason J Ong ◽  
Jun Jing ◽  
...  
Keyword(s):  
Logistic Regression ◽  
Human Papillomavirus ◽  
Cervical Intraepithelial Neoplasia ◽  
Sexually Transmitted Infections ◽  
Associated Factors ◽  
Intraepithelial Neoplasia ◽  
Multivariate Logistic Regression ◽  
Sexually Transmitted ◽  
Women Living With Hiv ◽  
Living With Hiv

ObjectiveWomen living with HIV (WLHIV) face disproportionately higher risks of acquiring human papillomavirus (HPV) compared with HIV negative counterparts. We aimed to investigate the prevalence of HPV in WLHIV in Chinese hospital setting and identify associated factors to the progression of late-stage cervical intraepithelial neoplasia (CIN2+) in this population.MethodThis retrospective study collected data from 183 WLHIV on antiretroviral treatment (ART), based on reproductive health questionnaires. Gynaecological examination results including serum (for HIV viral load, CD4 T-cell count, hepatitis B infections, syphilis) and vaginal swabs for common bacterial sexually transmitted infections (STIs). Multivariate-logistic regression was applied to analyze the contributing factors to CIN2+.ResultsHIV coinfection with other Sexually Transmitted Infections (STIs) were observed in 99 participants (54.1%, (99/183)). HPV (43.7% (80/183)) was the most prevalent STI. The three most prevalent HPV subtypes were all high-risk HPV (HR-HPV), including HPV52 (33.8% (27/80)), HPV58 (21.3% (17/80)) and HPV33 (13.75% (11/80)). About a third (37.5%, 30/80) of women with HPV had HR-HPV. Multiple HPV coinfections were common in HIV-HPV coinfected women (41.3%, 33/80). Cytological examinations revealed that 77.5% (62/80) HPV+ women had detectable cervical lesions. In comparison, only 4.9% (5/103) HPV negative womenwith Atypia and 1.0% (1/103) with CIN1 were diagnosed. Multivariate logistic regression revealed that HPV16 (OR=19.04, 2.53 to 122.92; p=0.004) and HPV18 (OR=11.54, 1.45 to 91.64; p=0.021) infections were significantly associated with CIN2+ in HIV-HPV coinfected women.ConclusionA high prevalence of HPV was found in women on ART. HPV16/18 infection are strong associated factors to CIN2+ in HIV-HPV coinfected women.

Human Papillomavirus Vaccination Prior to Loop Electroexcision Procedure Does Not Prevent Recurrent Cervical High-grade Squamous Intraepithelial Lesions in Women Living With Human Immunodeficiency Virus: A Randomized, Double-blind, Placebo-controlled Trial

2020 ◽  
Author(s):  
Cynthia Firnhaber ◽  
Avril Swarts ◽  
Vuyokazi Jezile ◽  
Masango Mulongo ◽  
Bridgette Goeieman ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Human Immunodeficiency Virus ◽  
Human Papillomavirus ◽  
Hpv Vaccination ◽  
High Grade ◽  
Double Blind ◽  
Women Living With Hiv ◽  
Immunodeficiency Virus ◽  
Living With Hiv ◽  
Intraepithelial Lesions

Abstract Background Women living with human immunodeficiency virus (HIV), especially in sub-Saharan Africa, are at high risk for cervical high-grade squamous intraepithelial lesions (HSIL) and cervical cancer. These women have high HSIL recurrence rates after loop electroexcision procedure (LEEP). Retrospective studies suggest that human papillomavirus (HPV) vaccination improves response to treatment of cervical HSIL. Methods We performed a double-blind, randomized clinical trial enrolling 180 women living with HIV in Johannesburg, South Africa, diagnosed with cervical HSIL by colposcopic biopsy. Women received quadrivalent HPV vaccine or placebo (1:1) at entry, week 4, and week 26. LEEP was performed at week 4. Colposcopic-directed biopsies and cervical cytology were performed at weeks 26 and 52. The primary endpoint, cervical HSIL by histology or cytology at either week 26 or 52, was compared between arms using χ 2 analysis. Results Participant characteristics included median age of 39 years and median CD4 count 489 cells/μL, and 94% had HIV suppression. One hundred seventy-four women completed the vaccine/placebo series and had evaluable results at week 26 or 52. The proportion experiencing the primary endpoint was similar in the vaccine and placebo groups (53% vs 45%; relative risk, 1.18 [95% confidence interval, .87–1.6]; P = .29). HSIL recurrence was associated with a LEEP biopsy result of HSIL and detection of HSIL at the margins of the LEEP sample. Conclusions This study did not support HPV vaccination to prevent recurrent HSIL after LEEP in women living with HIV. Recurrent HSIL was high despite virologic suppression. Improved treatments are needed for HSIL to reduce the burden of cervical cancer among women living with HIV.

scholarly journals The EVVA Cohort Study: Anal and Cervical Type-Specific Human Papillomavirus Prevalence, Persistence, and Cytologic Findings in Women Living With HIV

2017 ◽  
Vol 216 (4) ◽  
pp. 447-456 ◽  
Author(s):  
Alexandra de Pokomandy ◽  
Elaina Kaufman ◽  
Christina de Castro ◽  
Marie-Hélène Mayrand ◽  
Ann N Burchell ◽  
...  
Keyword(s):  
Cohort Study ◽  
Human Papillomavirus ◽  
Women Living With Hiv ◽  
Living With Hiv
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