INFLUENCE OF MESENCHYMAL STEM CELLS AND FIBRIN RICH PLASMA MEMBRANE TO REPAIR OSTEOCHONDRAL DEFECTS IN THE RABBIT KNEE

Cytotherapy ◽  
2021 ◽  
Vol 23 (4) ◽  
pp. 20
Author(s):  
JA Villanova ◽  
FM Oliveira ◽  
JC Wenceslau ◽  
DL Bona ◽  
L Fracaro ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Plasma Membrane ◽  
Osteochondral Defects ◽  
Rabbit Knee

Mesenchymal Stem Cells in the Treatment of Cartilage Defects of the Knee: A Systematic Review of the Clinical Outcomes

2021 ◽  
pp. 036354652098681
Author(s):  
Monketh Jaibaji ◽  
Rawan Jaibaji ◽  
Andrea Volpin
Keyword(s):  
Systematic Review ◽  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Stem Cell ◽  
Mesenchymal Stem Cell ◽  
Osteochondral Lesions ◽  
Common Source ◽  
Significant Heterogeneity ◽  
Osteochondral Defects

Background: Osteochondral lesions are a common clinical problem and their management has been historically challenging. Mesenchymal stem cells have the potential to differentiate into chondrocytes and thus restore hyaline cartilage to the defect, theoretically improving clincal outcomes in these patients. They can also be harvested with minimal donor site morbidity. Purpose: To assess the clinical and functional outcomes of mesenchymal stem cell implantation to treat isolated osteochondral defects of the knee. A secondary purpose is to assess the quality of the current available evidence as well as the radiological and histological outcomes. We also reviewed the cellular preparation and operative techniques for implantation. Study Design: Systematic review. Methods: A comprehensive literature search of 4 databases was carried out: CINAHL, Embase, MEDLINE, and PubMed. We searched for clinical studies reporting the outcomes on a minimum of 5 patients with at least 12 months of follow-up. Clinical, radiological, and histological outcomes were recorded. We also recorded demographics, stem cell source, culture technique, and operative technique. Methodological quality of each study was assessed using the modified Coleman methodology score, and risk of bias for the randomized controlled studies was assessed using the Cochrane Collaboration tool. Results: Seventeen studies were found, encompassing 367 patients. The mean patient age was 35.1 years. Bone marrow was the most common source of stem cells utilized. Mesenchymal stem cell therapy consistently demonstrated good short- to medium-term outcomes in the studies reviewed with no serious adverse events being recorded. There was significant heterogeneity in cell harvesting and preparation as well as in the reporting of outcomes. Conclusion: Mesenchymal stem cells demonstrated a clinically relevant improvement in outcomes in patients with osteochondral defects of the knee. More research is needed to establish an optimal treatment protocol, long-term outcomes, and superiority over other therapies. Registration: CRD42020179391 (PROSPERO).

Synovial Membrane–Derived Mesenchymal Stem Cells Supported by Platelet-Rich Plasma Can Repair Osteochondral Defects in a Rabbit Model

2013 ◽  
Vol 29 (6) ◽  
pp. 1034-1046 ◽  
Author(s):  
Jae-Chul Lee ◽  
Hyun Jin Min ◽  
Hee Jung Park ◽  
Sahnghoon Lee ◽  
Sang Cheol Seong ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Synovial Membrane ◽  
Platelet Rich Plasma ◽  
Rabbit Model ◽  
Osteochondral Defects

Predifferentiated Mesenchymal Stem Cells for Osteochondral Defects: Letter

2011 ◽  
Vol 39 (6) ◽  
pp. NP12-NP15
Author(s):  
Andreas Schmitt ◽  
Andreas B. Imhoff ◽  
Stephan Vogt
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Osteochondral Defects

scholarly journals Repair of osteochondral defects with biodegradable hydrogel composites encapsulating marrow mesenchymal stem cells in a rabbit model

2010 ◽  
Vol 6 (1) ◽  
pp. 39-47 ◽  
Author(s):  
Xuan Guo ◽  
Hansoo Park ◽  
Simon Young ◽  
James D. Kretlow ◽  
Jeroen J. van den Beucken ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Rabbit Model ◽  
Osteochondral Defects ◽  
Marrow Mesenchymal Stem Cells ◽  
Biodegradable Hydrogel ◽  
Hydrogel Composites

scholarly journals Osteochondral repair in hemophilic ankle arthropathy: from current options to future perspectives

Joints ◽  
2015 ◽  
Vol 03 (04) ◽  
pp. 201-207 ◽  
Author(s):  
Roberto Buda ◽  
Marco Cavallo ◽  
Francesco Castagnini ◽  
Enrico Ferranti ◽  
Simone Natali ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Growth Factors ◽  
Osteochondral Defects ◽  
Future Perspectives ◽  
Mesenchymal Stem Cell Transplantation ◽  
Slowing Down ◽  
Osteochondral Repair ◽  
Chondrocyte Implantation ◽  
End Stage

Young hemophilic patients are frequently affected by ankle arthropathy. At the end stage of the disease, the current treatments are arthrodesis and arthroplasty, which have significant drawbacks. Validated procedures capable of slowing down or even arresting the progression towards the end stage are currently lacking. This review aims to discuss the rationale for and feasibility of applying, in mild hemophilic ankle arthropathy, the main techniques currently used to treat osteochondral defects, focusing in particular on ankle distraction, chondrocyte implantation, mesenchymal stem cell transplantation, allograft transplantation and the use of growth factors. To date, ankle distraction is the only procedure that has been successfully used in hemophilic ankle arthropathy. The use of mesenchymal stem cells have recently been evaluated as feasible for osteochondral repair in hemophilic patients. There may be a rationale for the use of growth factors if they are combined with the previous techniques, which could be useful to arrest the progression of the degeneration or delay end-stage procedures.

Specific plasma membrane protein phenotype of culture-amplified and native human bone marrow mesenchymal stem cells

Blood ◽  
2008 ◽  
Vol 111 (5) ◽  
pp. 2631-2635 ◽  
Author(s):  
Bruno Delorme ◽  
Jochen Ringe ◽  
Nathalie Gallay ◽  
Yves Le Vern ◽  
Dominique Kerboeuf ◽  
...  
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Mesenchymal Stem Cells ◽  
Plasma Membrane ◽  
Membrane Protein ◽  
Mononuclear Cells ◽  
Mesenchymal Cells ◽  
Plasma Membrane Protein ◽  
Native Bone ◽  
Marrow Mesenchymal Stem Cells

We have studied the plasma membrane protein phenotype of human culture-amplified and native bone marrow mesenchymal stem cells (BM MSCs). We have found, using microarrays and flow cytometry, that cultured cells express specifically 113 transcripts and 17 proteins that were not detected in hematopoietic cells. These antigens define a lineage-homogenous cell population of mesenchymal cells, clearly distinct from the hematopoietic lineages, and distinguishable from other cultured skeletal mesenchymal cells (periosteal cells and synovial fibroblasts). Among the specific membrane proteins present on cultured MSCs, 9 allowed the isolation from BM mononuclear cells of a minute population of native MSCs. The enrichment in colony-forming units–fibroblasts was low for CD49b, CD90, and CD105, but high for CD73, CD130, CD146, CD200, and integrin alphaV/beta5. In addition, the expression of CD73, CD146, and CD200 was down-regulated in differentiated cells. The new marker CD200, because of its specificity and immunomodulatory properties, deserves further in-depth studies.

Osteoblast-Derived Giant Plasma Membrane Vesicles Induce Osteogenic Differentiation of Human Mesenchymal Stem Cells

2018 ◽  
Vol 2 (9) ◽  
pp. 1800093
Author(s):  
Deepanjali Gaur ◽  
Yamini Yogalakshmi ◽  
Senthilguru Kulanthaivel ◽  
Tarun Agarwal ◽  
Devdeep Mukherjee ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Plasma Membrane ◽  
Osteogenic Differentiation ◽  
Human Mesenchymal Stem Cells ◽  
Membrane Vesicles ◽  
Plasma Membrane Vesicles
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