Platelet-rich plasma combined with intralesional triamcinolone acetonide for the treatment of alopecia areata: A case report

Background: Alopecia areata (AA) is a chronic inflammatory disease characterized by nonscarring hair loss involving any hair-bearing surface of the body. The current therapy for AA is not curative but rather aimed at controlling or limiting the pathogenic process. Corticosteroids are the most popular drugs used, however localized atrophy is a common complication, particularly with triamcinolone. Promoting hair growth by application of autologous blood extracted platelet rich plasma (PRP) is a simple, yet effective procedure. The aim of the study was to evaluate and compare the efficacy of intralesional triamcinolone acetonide (5 mg/ml) with intralesional PRP in the treatment of two different scalp AA patches of same individual.Methods: A total of 30 patients having ≥2 patches of AA were randomized and given two separate modalities of treatment in two different patches and divided in Group I, treated with intralesional triamcinolone acetonide (5 mg/ml) and Group II, treated with PRP. Interval time between every follow-up was 3 weeks and four such follow-ups were done. Hair regrowth was calculated according to Mac Donald Hull and Norris grading system at every follow-up and was compared with the initial grading.Results: Group I patches, treated with triamcinolone acetonide have the significantly higher mean grading score than the group II patches, treated with PRP at each follow up.Conclusions: Intralesional triamcinolone acetonide is more efficacious than intralesional PRP in the treatment of scalp alopecia areata with no recurrences and very few adverse effects like atrophy and hypopigmentation.

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Transepidermal Delivery of Triamcinolone Acetonide or Platelet Rich Plasma Using Either Fractional Carbon Dioxide Laser or Microneedling in Treatment of Alopecia Areata

Case Medical Research ◽

10.31525/ct1-nct04147845 ◽

2019 ◽

Author(s):

Keyword(s):

Carbon Dioxide ◽

Triamcinolone Acetonide ◽

Alopecia Areata ◽

Carbon Dioxide Laser ◽

Platelet Rich Plasma ◽

Fractional Carbon Dioxide Laser

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Total Regrowth in Chronic Severe Alopecia Areata Treated with Platelet Rich Plasma: A Case Report and Literature Review

International Society of Hair Restoration Surgery ◽

10.33589/25.5.0190 ◽

2015 ◽

Vol 25 (5) ◽

pp. 190-191

Author(s):

Anastasios Vekris ◽

Dimitra Zafeiratou ◽

Antonia Andriopoulou ◽

Amalia Tsiatoura

Keyword(s):

Case Report ◽

Literature Review ◽

Alopecia Areata ◽

Platelet Rich Plasma

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A clinical study on alopecia areata

International Journal of Research in Dermatology ◽

10.18203/issn.2455-4529.intjresdermatol20180143 ◽

2018 ◽

Vol 4 (1) ◽

pp. 66

Author(s):

Kishan Ninama ◽

Rashmi Mahajan ◽

F. E. Bilimoria ◽

Ashvin Vaghani

Keyword(s):

Triamcinolone Acetonide ◽

Alopecia Areata ◽

Platelet Rich Plasma ◽

Pulse Therapy ◽

Treatment Modalities ◽

Systemic Corticosteroids ◽

First Choice ◽

Group 3 ◽

Group 2 ◽

Group 1

Background: Alopecia areata (AA) is a common auto-immune condition, causing hair loss. This disease has limited treatment modalities. Through this study, comparison between established modalities of treatment such as oral mini pulse therapy, intralesional corticosteroids and platelet-rich plasma (PRP) as a newer modality has been done. The objective of the study was to evaluate the efficacy and safety of various treatment modalities in alopecia areata.Methods: 45 patients with alopecia areata presenting to the OPD of Dermatology, Dhiraj hospital, Pipariya were included in this study. It was conducted as a randomized prospective study for a period of 16 weeks. After taking informed consent, patients were randomly distributed into three treatment groups. Group 1 patients were treated with Tab. Betamethasone 0.1 mg/kg every Saturday and Sunday, Group 2 was treated with Inj. Triamcinolone acetonide 10 mg/ml for scalp and 2.5 mg/ml for eye brows and face was injected into deep dermis; Group 3 was treated with Dermaroller followed by application of activated platelet rich plasma (PRP). SALT score was calculated at first visit and 16 weeks. Regrowth was calculated using Mac Donald and Null Horis grading Scale at 16 weeks.Results: The SALT score reduced from 13.27 to 7.52 in Group 1, 13.93 to 8.16 in Group 2 and 42.32 to 21.12 in Group 3. Mean grade of regrowth of hairs observed was 3.47, 3.80, 2.93 in Group 1, 2, 3 respectively. The results were analysed using paired t test.Conclusions:Intralesional corticosteroids viz. triamcinolone acetonide still remains the first choice of therapy for AA in adults with limited involvement. Systemic corticosteroids give lower response than intralesional steroids. Platelet Rich Plasma (PRP) showed promising results, especially in children and in extensive involvement. Compared to other treatment modalities Inj. PRP is safe and with less side effects.

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