Increasing bioavailability of very poorly water-soluble compounds. A case study of an anti-tumor drug, soloxolon methyl

Enhanced Bioavailability of a Poorly Water-Soluble Weakly Basic Compound Using a Combination Approach of Solubilization Agents and Precipitation Inhibitors: A Case Study

Molecular Pharmaceutics ◽

10.1021/mp200352q ◽

2012 ◽

Vol 9 (5) ◽

pp. 1100-1108 ◽

Cited By ~ 31

Author(s):

Shu Li ◽

Crystal Pollock-Dove ◽

Liang C. Dong ◽

Jing Chen ◽

Abla A. Creasey ◽

...

Keyword(s):

Water Soluble ◽

Precipitation Inhibitors ◽

Poorly Water Soluble ◽

Combination Approach

In Vitro Dissolution Screening for PK Formulation Selection for Poorly Water-Soluble Drugs: A Case Study

10.26226/morressier.57d6b2bdd462b8028d88e544 ◽

2016 ◽

Author(s):

Emanuela Del Vesco

Keyword(s):

Water Soluble ◽

In Vitro Dissolution ◽

Water Soluble Drugs ◽

Poorly Water Soluble ◽

Selection For

Enabling Technology Screening and Formulation Selection for Poorly Water-Soluble Drugs: A Case Study

10.26226/morressier.57d6b2bdd462b8028d88d7c3 ◽

2016 ◽

Author(s):

Emanuela Del Vesco

Keyword(s):

Water Soluble ◽

Enabling Technology ◽

Water Soluble Drugs ◽

Poorly Water Soluble ◽

Selection For

Impact of surface area of silica particles on dissolution rate and oral bioavailability of poorly water soluble drugs: A case study with aceclofenac

International Journal of Pharmaceutics ◽

10.1016/j.ijpharm.2013.12.017 ◽

2014 ◽

Vol 461 (1-2) ◽

pp. 459-468 ◽

Cited By ~ 38

Author(s):

Dinesh Kumar ◽

S.V. Sailaja Chirravuri ◽

Nalini R. Shastri

Keyword(s):

Dissolution Rate ◽

Surface Area ◽

Oral Bioavailability ◽

Silica Particles ◽

Water Soluble ◽

Water Soluble Drugs ◽

Comparative studies of the in vitro dissolution and in vivo pharmacokinetics for different formulation strategies (solid dispersion, micronization, and nanocrystals) for poorly water-soluble drugs: A case study for lacidipine

Colloids and Surfaces B Biointerfaces ◽

10.1016/j.colsurfb.2015.05.010 ◽

2015 ◽

Vol 132 ◽

pp. 171-176 ◽

Cited By ~ 17

Author(s):

Qiang Fu ◽

Bo Li ◽

Dong Zhang ◽

Mingming Fang ◽

Jingbo Shao ◽

...

Keyword(s):

Solid Dispersion ◽

Water Soluble ◽

In Vitro Dissolution ◽

Water Soluble Drugs ◽

Poorly Water Soluble ◽

In Vivo Pharmacokinetics

Physical State of Poorly Water Soluble Therapeutic Molecules Loaded into SBA-15 Ordered Mesoporous Silica Carriers: A Case Study with Itraconazole and Ibuprofen

Langmuir ◽

10.1021/la801161g ◽

2008 ◽

Vol 24 (16) ◽

pp. 8651-8659 ◽

Cited By ~ 165

Author(s):

Randy Mellaerts ◽

Jasper A. G. Jammaer ◽

Michiel Van Speybroeck ◽

Hong Chen ◽

Jan Van Humbeeck ◽

...

Keyword(s):

Mesoporous Silica ◽

Physical State ◽

Water Soluble ◽

Ordered Mesoporous Silica ◽

Ordered Mesoporous ◽

Therapeutic Molecules ◽

Self-assembling PEG-p(CL-co-TMC) copolymers for oral delivery of poorly water-soluble drugs: a case study with risperidone

Journal of Controlled Release ◽

10.1016/j.jconrel.2004.10.022 ◽

2005 ◽

Vol 102 (3) ◽

pp. 657-668 ◽

Cited By ~ 47

Author(s):

Louisa Ould-Ouali ◽

Marc Noppe ◽

Xavier Langlois ◽

Bart Willems ◽

Paula Te Riele ◽

...

Keyword(s):

Oral Delivery ◽

Water Soluble ◽

Self Assembling ◽

Water Soluble Drugs ◽

Solid microcrystalline dispersion films as a new strategy to improve the dissolution rate of poorly water soluble drugs: A case study using olanzapine

International Journal of Pharmaceutics ◽

10.1016/j.ijpharm.2016.05.012 ◽

2016 ◽

Vol 508 (1-2) ◽

pp. 42-50 ◽

Cited By ~ 19

Author(s):

Laura Modica de Mohac ◽

Maria de Fátima Pina ◽

Bahijja Tolulope Raimi-Abraham

Keyword(s):

Dissolution Rate ◽

Water Soluble ◽

New Strategy ◽

Water Soluble Drugs ◽

Cryosynthesis of Co-Crystals of Poorly Water-Soluble Pharmaceutical Compounds and Their Solid Dispersions with Polymers. The “Meloxicam–Succinic Acid” System as a Case Study

Crystal Growth & Design ◽

10.1021/acs.cgd.8b01070 ◽

2018 ◽

Vol 18 (12) ◽

pp. 7401-7409 ◽

Cited By ~ 7

Author(s):

Andrey G. Ogienko ◽

Svetlana A. Myz ◽

Anna A. Ogienko ◽

Andrey A. Nefedov ◽

Andrey S. Stoporev ◽

...

Keyword(s):

Succinic Acid ◽

Solid Dispersions ◽

Pharmaceutical Compounds ◽

Water Soluble ◽

Acid System ◽

Early identification of availability issues for poorly water-soluble microbicide candidates in biorelevant media: A case study with saquinavir

Antiviral Research ◽

10.1016/j.antiviral.2011.06.001 ◽

2011 ◽

Vol 91 (2) ◽

pp. 217-223 ◽

Cited By ~ 8

Author(s):

Joachim Brouwers ◽

Kurt Vermeire ◽

Carolien Grammen ◽

Dominique Schols ◽

Patrick Augustijns

Keyword(s):

Early Identification ◽

Water Soluble ◽

Biorelevant Media ◽