Molecular modeling prediction of albumin-based nanoparticles and experimental preparation, characterization, and in-vitro release kinetics of prednisolone from the nanoparticles

2021 ◽  
pp. 102588
Author(s):  
S. Fatemeh Kaboli ◽  
Faramarz Mehrnejad ◽  
Ali Nematollahzadeh
Keyword(s):  
Molecular Modeling ◽  
Release Kinetics ◽  
In Vitro Release ◽  
Modeling Prediction ◽  
Kinetics Of ◽  
Vitro Release ◽  
Experimental Preparation

Formulation and In Vitro Release Kinetics of Mucoadhesive Blend Gels Containing Matrine for Buccal Administration

2017 ◽  
Vol 19 (1) ◽  
pp. 470-480 ◽  
Author(s):  
Xiaojin Chen ◽  
Jun Yan ◽  
Shuying Yu ◽  
Pingping Wang
Keyword(s):  
Release Kinetics ◽  
In Vitro Release ◽  
Kinetics Of ◽  
Vitro Release

scholarly journals Preparation and in vitro release kinetics of nitrendipine-loaded PLLA–PEG–PLLA microparticles by supercritical solution impregnation process

RSC Advances ◽  
2019 ◽  
Vol 9 (28) ◽  
pp. 16167-16175 ◽  
Author(s):  
Shiping Zhan ◽  
Jingchang Wang ◽  
Weijing Wang ◽  
Liyun Cui ◽  
Qicheng Zhao
Keyword(s):  
Release Kinetics ◽  
Drug Carrier ◽  
In Vitro Release ◽  
Impregnation Process ◽  
Supercritical Solution ◽  
Model Drug ◽  
Polymer Microparticles ◽  
Kinetics Of ◽  
Vitro Release

In this work, drug-loaded polymer microparticles were prepared by a supercritical solution impregnation (SSI) process with nitrendipine as the model drug and PLLA–PEG–PLLA as the drug carrier.

scholarly journals In Vitro Release Study of the Polymeric Drug Nanoparticles: Development and Validation of a Novel Method

Pharmaceutics ◽  
2020 ◽  
Vol 12 (8) ◽  
pp. 732
Author(s):  
Jingwen Weng ◽  
Henry H. Y. Tong ◽  
Shing Fung Chow
Keyword(s):  
Polymeric Nanoparticles ◽  
Release Kinetics ◽  
In Vitro Release ◽  
The United States ◽  
Drug Nanoparticles ◽  
Polymeric Drug ◽  
Release Study ◽  
Kinetics Of ◽  
Vitro Release

The in vitro release study is a critical test to assess the safety, efficacy, and quality of nanoparticle-based drug delivery systems, but there is no compendial or regulatory standard. The variety of testing methods makes direct comparison among different systems difficult. We herein proposed a novel sample and separate (SS) method by combining the United States Pharmacopeia (USP) apparatus II (paddle) with well-validated centrifugal ultrafiltration (CU) technique that efficiently separated the free drug from nanoparticles. Polymeric drug nanoparticles were prepared by using a four-stream multi-inlet vortex mixer with d-α-tocopheryl polyethylene glycol 1000 succinate as a stabilizer. Itraconazole, cholecalciferol, and flurbiprofen were selected to produce three different nanoparticles with particle size <100 nm. By comparing with the dialysis membrane (DM) method and the SS methods using syringe filters, this novel SS + CU technique was considered the most appropriate in terms of the accuracy and repeatability to provide the in vitro release kinetics of nanoparticles. Interestingly, the DM method appeared to misestimate the release kinetics of nanoparticles through separate mechanisms. This work offers a superior analytical technique for studying in vitro drug release from polymeric nanoparticles, which could benefit the future development of in vitro-in vivo correlation of polymeric nanoparticles.

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