Antioxidant Activity Test Of Endophyte Fungi Extract From Kayu Jawa (Lannea coromandelica (Houtt.) Merr.) Roots Using Dpph Method (2,2-Diphenyl-1-1-Picrylhydrazyl)

Indonesia has abundant and diverse natural resources from land and sea. These biological natural resources can be explored as medicinal materials well-sourced from plants, animals, or microorganisms. Endophytic fungus is a microbial resource that grows in plant tissues that can produce compounds that have the same efficacy as the host plant. Zulfa (2016) has successfully isolated the endophytic fungi from kayu Jawa (Lannea coromandelica) roots and extracted the extracts with given code A11KA, A11KB, A12KC, A12KD, A21KK, A22KJ, AP12A, AP13L, AP21C, and AP32I. Other activities in these extracts besides antibacterial activity need to be tested. So this study was conducted to test the antioxidant activity of the extract with the DPPH method and used vitamin C positive control. Fifteen samples were obtained in this study, they are MeOH A11KA; MeOH A11KB; MeOH A12KC; MeOH A12KD; MeOH A21KK; MeOH AP12A; MeOH AP13L; MeOH AP12C; MeOH AP321; EA A11KA; EA A12KC; EA AP321; EA AP12A; EA AP13L; EA A22KJ from methanol fractions (MeOH) and ethyl acetate fraction (EA). The antioxidant activity test results showed that only six samples were potential as antioxidants. Value of AAI (Antioxidant Activity Index) EA A12KC; EA A11KA; MeOH A11KA; EA AP321; MeOH AP21C; EA A22KJ and vitamin C are 2.27 (very strong), 2.07 (very strong), 1.78 (strong), 1.19 (strong), 0.81 (medium), 0.53 (medium) and 11.67 (very strong) respectively. The result of antioxidant analysis using GC-MS showed only EA A11KA showing the presence of phenol compound, the largest phenol compound in this sample was phenol, 2,4-bis (1,1-dimethyl ethyl).

Economically Feasible Wood Biopreservation Platform in Lannea coromandelica (Houtt.) Merr. Against Wood Rotting Fungus Through Bio-Prospecting Weed Extracts

As an alternative to synthetic preservatives, the use of plant-based, environmentally sustainable preservatives for wood protection has tremendous potential. The current research analyzed the dimensional stability and longevity of Lannea coromandelica wood using weed extracts viz. Lantana camara L. and Ageratum conyzoides L., respectively. Petroleum ether (PE) and methanolic weed extracts were used to treat wood blocks (5 cm × 2.5 cm × 2.5 cm) at varying concentrations ranging from 0.25 to 2.00%. The PE extract of A. conyzoides resulted in maximum swelling (tangential plane, 6.30%) at 2.00%, volumetric swelling coefficient (13.17%) at 1.50%, and volumetric shrinkage coefficient (7.71%) at 1.00% concentration, while maximum shrinkage (tangential plane, 4.10%) in methanol (M) extract was observed. In L. camara methanolic extract (1.00%), maximum anti-shrink efficiency (37.01%) was recorded. In vitro mycelial growth of the wood-rotting fungus was completely inhibited by PE extract from both weeds. However, the methanolic extract of A. conyzoides resulted in maximal inhibition (75.93%) at a concentration of 2.00%. Also, PE extract (2.00%) of A. conyzoides reduced the fungal colonization to 50%, as compared with control. The lowest weight loss (decay test, 12 weeks) was observed at a 2.00% concentration of L. camara PE extract. The present research highlighted that both A. conyzoides and L. camara could be used as an environmentally sustainable wood preservative substitute that will encourage the utilization of L. coromandelica in wood-based industries.

Ingredients of Active Compounds and Anti-Diabetic Test of Water Extract of Lannea coromandelica (Houtt) Merr. On Wistar Rats

Leaves of Lannea coromandelica (Houtt.) Merr. is one of the plants found in Aceh. This study aims to determine the effect of giving water extract of Lannea coromandellica (Houtt.) Merr. against STZ-induced blood sugar levels of wistar rats. The experimental study used a sample of 25 male and 15 female Wistar rats. This research is experimental with a sample of 25 male and 15 female of Wistar rats. The treatments were given, namely negative control (aquades), positive control (metformin), 50 mg EALC, 100 mg EALC, and 150 mg EALC. The data obtained will be analyzed by using the Kruskal Wallis test to obtain the effectiveness of the treatment and also a descriptive analysis for the average reduction in blood glucose levels. Macro and histological observations were also carried out on the liver and pancreas. The results obtained from the Kruskal Wallis test results showed that there was no effect of EALC on changes in the decrease in blood glucose levels of wistar rats for 14 days of treatment. Observation of the macro organs showed pancreas had a changes. While the histological observations pancreas and liver showed changes. The results of this study indicate that the effectiveness of EALC is not proven to have an effect, this is presumably because the extract concentration is too small so it is not enough to work optimally. Phytochemical test shows that EALC contains flavonoids, steroids, phenolics, tannins, saponins and alkaloids.

Lannea coromandelica: An Overview

Plants serve humans as primary sources for food, shelter and medicines. So understanding the plant uses in treating the diseases is very important for leading a healthier life. Our ancestors have used many plants as medicines and there is a need to provide scientific evidence for the same. Lannea coromandelica from family Anacardiaceae is one of the potent remedial plant. It is known as Modhad or Moi in Vernacular language and is found to be distributed throughout India. It is one of the common plants of deciduous forest and plains .It was extensively used by the tribes all over India to treat various diseases. Many investigations on the chemistry of the plant have been done. This article reviews about the plant L. coromandelica. Keywords: Lannea coromandelica , Anacardiaceae

Exploratory Research on the Effectiveness of Lannea coromandelica in Streptozotocin Induced Diabetic Model: A Protocol for Systematic Review

Introduction: Diabetes mellitus is a metabolic disorder affecting human population since many centuries ago. To contend this disorder, effective alternative use of non-pharmacological approaches, particularly natural herbal plants, has become a subject of interest since the last decade. Aim: To evaluate the safety and effectiveness of Lannea coromandelica in the management of diabetes mellitus. Materials and Methods: A systematic review on randomised controlled trials will be carried out. Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines will be followed. The search strategies will be conducted in PubMed/MEDLINE, J-Gate, EMBASE, COCHRANE database and Google Scholar. The search period will be included from 1968 to December 2020. The screening process will be initiated by two authors for title and abstract followed by four authors for full-text articles. The extraction will be performed by using the following characteristics-Study design, Animal model, Intervention of interest. Conclusion: This current review will provide evidence based on the available literature either to accept or reject the hypothesis that efficacy of Lannea coromandelica herbal plant may be beneficial for controlling glucose levels in diabetic model.

AN EXPERIMENTAL STUDY TO EVALUATE CARDIOPROTECTIVE ACTIVITY OF JINGINI LANNEA COROMANDELICA MERR (HOUTT): AN IN VIVO STUDY

Jingini - Lannea coromandelica Merr. (Houtt) is mentioned in Bhava Prakasha Nighantu and Bhavamishra advocates JINGINI for Hridroga. An experimental study was designed with a Model - Isoproterenol (ISO) Induced Cardiac toxicity in order to prove the efficacy of JINGINI for its Cardioprotective activity. Animals were administered with Aqueous and Methanolic extract of JINIGINI in higher and lower dose. The Acute toxicity studies were conducted up to 5000 mg/kg body weight in accordance with OECD 425 guidelines. The higher dose calculated from 1/5th of 5000 mg/kg body weight which summed up to 1000 mg/kg body weight and lower dose calculated from 1/10th of 5000 mg/kg body weight was concluded as 500 mg/kg body weight. The Methanolic extract of JINGINI in Higher and Lower dose (1000 mg/kg body weight and 500 mg /kg body weight respectively) was found to be efficacious in providing the Cardio-protective action in SD Rats.