Distribution of cannabinoid receptor 1 (CB1) and 2 (CB2) on sensory nerve fibers and adnexal structures in human skin

2005 ◽  
Vol 38 (3) ◽  
pp. 177-188 ◽  
Author(s):  
Sonja Ständer ◽  
Martin Schmelz ◽  
Dieter Metze ◽  
Thomas Luger ◽  
Roman Rukwied
Keyword(s):  
Human Skin ◽  
Cannabinoid Receptor ◽  
Sensory Nerve ◽  
Nerve Fibers ◽  
Cannabinoid Receptor 1

Increased Cannabinoid Receptor 1-Immunoreactive Nerve Fibers in Overactive and Painful Bladder Disorders and Their Correlation With Symptoms

Urology ◽  
2010 ◽  
Vol 75 (6) ◽  
pp. 1514.e15-1514.e20 ◽  
Author(s):  
Gaurav Mukerji ◽  
Yiangos Yiangou ◽  
Sanjiv K. Agarwal ◽  
Praveen Anand
Keyword(s):  
Cannabinoid Receptor ◽  
Nerve Fibers ◽  
Cannabinoid Receptor 1 ◽  
Painful Bladder ◽  
Bladder Disorders

Localization of Merkel cells at hairless and hairy human skin sites using keratin 18

1995 ◽  
Vol 73 (9-10) ◽  
pp. 635-639 ◽  
Author(s):  
Julie Fradette ◽  
Marie-Josée Godbout ◽  
Martine Michel ◽  
Lucie Germain
Keyword(s):  
Human Skin ◽  
Basal Layer ◽  
Sensory Nerve ◽  
Neurosecretory Cells ◽  
Nerve Fibers ◽  
Hair Follicles ◽  
Merkel Cells ◽  
Merkel Cell ◽  
Skin Receptor ◽  
And Function

Merkel cells are neurosecretory cells of the skin with epithelial features such as desmosomes and expression of keratins 8, 18, 19, and 20. Merkel cells are scarcely distributed in adult human skin. Although they are present in hair follicles, their density is higher at hairless anatomic sites such as palms and soles. These cells are often innervated by sensory nerve fibers and are thought to be specialized mechanosensory skin receptor cells. However, their precise origin and function are not clearly established. The aim of this study was to localize Merkel cells in human hairless and hairy skin by immunohistochemistry with antibodies Ks18.174 and Ks19.1 directed against keratins 18 and 19, respectively. In glabrous skin of palm and sole, Merkel cells have been localized at the bottom of the rete ridges, in the epidermal basal layer. To study Merkel cell distribution at hairy anatomic sites, we have chosen breast skin, a tissue containing small hair follicles typical of those covering most of the body's surface. Merkel cells were present in the interfollicular epidermis. In hair follicles, they have been identified in the isthmus region.Key words: skin, human, Merkel cell, keratin, hair follicle.

scholarly journals 425 Mast cells survival and maturation in human skin are regulated and maintained by sensory nerve fibers

2016 ◽  
Vol 136 (5) ◽  
pp. S75 ◽  
Author(s):  
J. Chéret ◽  
L. Ponce ◽  
C. Le Gall-Ianotto ◽  
L. Misery ◽  
M. Bertolini ◽  
...  
Keyword(s):  
Mast Cells ◽  
Human Skin ◽  
Sensory Nerve ◽  
Nerve Fibers

Localization of μ-opioid receptor 1A on sensory nerve fibers in human skin

2002 ◽  
Vol 110 (1) ◽  
pp. 75-83 ◽  
Author(s):  
Sonja Ständer ◽  
Matthias Gunzer ◽  
Dieter Metze ◽  
Thomas Luger ◽  
Martin Steinhoff
Keyword(s):  
Human Skin ◽  
Opioid Receptor ◽  
Sensory Nerve ◽  
Nerve Fibers ◽  
Μ Opioid Receptor

A semi-automated analysis method of small sensory nerve fibers in human skin-biopsies

2010 ◽  
Vol 185 (2) ◽  
pp. 325-337 ◽  
Author(s):  
Kazuyuki Tamura ◽  
Violet A. Mager ◽  
Lindsey A. Burnett ◽  
John H. Olson ◽  
Jeremy B. Brower ◽  
...  
Keyword(s):  
Human Skin ◽  
Sensory Nerve ◽  
Automated Analysis ◽  
Nerve Fibers ◽  
Analysis Method ◽  
Skin Biopsies

Mitochondrial energy metabolism is negatively regulated by cannabinoid receptor 1 in intact human epidermis

2020 ◽  
Vol 29 (7) ◽  
pp. 616-622 ◽  
Author(s):  
Attila Oláh ◽  
Majid Alam ◽  
Jérémy Chéret ◽  
Nikolett Gréta Kis ◽  
Zoltán Hegyi ◽  
...  
Keyword(s):  
Energy Metabolism ◽  
Cannabinoid Receptor ◽  
Human Epidermis ◽  
Cannabinoid Receptor 1 ◽  
Mitochondrial Energy Metabolism

scholarly journals Axon typing of rat muscle nerves using a double staining procedure for cholinesterase and carbonic anhydrase.

1991 ◽  
Vol 39 (12) ◽  
pp. 1617-1625 ◽  
Author(s):  
M J Szabolcs ◽  
A Windisch ◽  
R Koller ◽  
M Pensch
Keyword(s):  
Carbonic Anhydrase ◽  
Cross Sections ◽  
Sensory Nerve ◽  
Histological Section ◽  
Trapezius Muscle ◽  
Motor Units ◽  
Conventional Technique ◽  
Nerve Fibers ◽  
Staining Procedure ◽  
Muscle Nerve

We developed a method for detecting activity of axonal cholinesterase (CE) and carbonic anhydrase (CA)--markers for motor and sensory nerve fibers (NFs)--in the same histological section. To reach this goal, cross-sections of muscle nerves were sequentially incubated with the standard protocols for CE and CA histochemistry. A modified incubation medium was used for CA in which Co++ is replaced by Ni++. This avoids interference of the two histochemical reactions because Co++ binds unspecifically to the brown copper-ferroferricyanide complex representing CE activity, whereas Ni++ does not. Cross-sections of the trapezius muscle nerve containing efferent and afferent NFs in segregated fascicles showed that CE activity was confined to motor NFs. Axonal CA was detected solely in sensory NFs. The number of labeled motor and sensory NFs determined in serial cross-sections stained with either the new or the conventional technique was not significantly different. Morphometric analysis revealed that small unreactive NFs (diameter less than 5 microns) are afferent, medium-sized ones (5 microns less than d less than 7 microns) are unclassifiable, and large ones (d greater than 7 microns) are efferent. The heterogenous CE activity of thick (alpha) motor NFs is linked to the type of their motor units. "Fast" motor units contain CE reactive NFs; "slow" ones have CE negative neurites.

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