scholarly journals 425 Mast cells survival and maturation in human skin are regulated and maintained by sensory nerve fibers

2016 ◽  
Vol 136 (5) ◽  
pp. S75 ◽  
Author(s):  
J. Chéret ◽  
L. Ponce ◽  
C. Le Gall-Ianotto ◽  
L. Misery ◽  
M. Bertolini ◽  
...  
Keyword(s):  
Mast Cells ◽  
Human Skin ◽  
Sensory Nerve ◽  
Nerve Fibers

Functional relationships between sensory nerve fibers and mast cells of dura mater in normal and inflammatory conditions

Neuroscience ◽  
1997 ◽  
Vol 77 (3) ◽  
pp. 829-839 ◽  
Author(s):  
V Dimitriadou ◽  
A Rouleau ◽  
M.D Trung Tuong ◽  
G.J.F Newlands ◽  
H.R.P Miller ◽  
...  
Keyword(s):  
Mast Cells ◽  
Dura Mater ◽  
Sensory Nerve ◽  
Nerve Fibers ◽  
Functional Relationships ◽  
Inflammatory Conditions

Relationships between permeable vessels, nerves, and mast cells in rat cutaneous neurogenic inflammation

1990 ◽  
Vol 68 (6) ◽  
pp. 2305-2311 ◽  
Author(s):  
J. N. Baraniuk ◽  
M. L. Kowalski ◽  
M. A. Kaliner
Keyword(s):  
Electrical Stimulation ◽  
Mast Cells ◽  
Neurogenic Inflammation ◽  
Sensory Nerve ◽  
Nerve Fibers ◽  
Sensory Nerves ◽  
Neurokinin A ◽  
Rat Skin ◽  
Protein Extravasation ◽  
Stimulation Of

Electrical stimulation of rat sensory nerves produces cutaneous vasodilation and plasma protein extravasation, a phenomenon termed “neurogenic inflammation”. Rat skin on the dorsum of the paw developed neurogenic inflammation after electrical stimulation of the saphenous nerve. In tissue sections, the extravasation of the supravital dye monastral blue B identified permeable vessels. Mast cells were identified by toluidine blue stain. Permeable vessels were significantly more dense in the superficial 120 microns of the dermis than in the deeper dermis, whereas mast cells were significantly more frequent in the deeper dermis. The relationships between nociceptive sensory nerve fibers, permeable vessels, and mast cells were examined by indirect immunohistochemistry for calcitonin gene-related peptide (CGRP), neurokinin A (NKA), and substance P (SP). CGRP-, NKA-, and SP-containing nerves densely innervated the superficial dermis and appeared to innervate the vessels that became permeable during neurogenic inflammation. In contrast, mast cells were not associated with either permeable vessels or nerve fibers. These data suggest that electrical stimulation of rat sensory nerves produces vascular permeability by inducing the release of neuropeptides that may directly stimulate the superficial vascular bed. Mast cells may not be involved in this stage of cutaneous neurogenic inflammation in rat skin.

Distribution of cannabinoid receptor 1 (CB1) and 2 (CB2) on sensory nerve fibers and adnexal structures in human skin

2005 ◽  
Vol 38 (3) ◽  
pp. 177-188 ◽  
Author(s):  
Sonja Ständer ◽  
Martin Schmelz ◽  
Dieter Metze ◽  
Thomas Luger ◽  
Roman Rukwied
Keyword(s):  
Human Skin ◽  
Cannabinoid Receptor ◽  
Sensory Nerve ◽  
Nerve Fibers ◽  
Cannabinoid Receptor 1

Expression of vanilloid receptor subtype 1 in cutaneous sensory nerve fibers, mast cells, and epithelial cells of appendage structures

2004 ◽  
Vol 13 (3) ◽  
pp. 129-139 ◽  
Author(s):  
Sonja Stander ◽  
Corinna Moormann ◽  
Mark Schumacher ◽  
Jorg Buddenkotte ◽  
Metin Artuc ◽  
...  
Keyword(s):  
Mast Cells ◽  
Epithelial Cells ◽  
Sensory Nerve ◽  
Nerve Fibers ◽  
Vanilloid Receptor ◽  
Receptor Subtype

Localization of Merkel cells at hairless and hairy human skin sites using keratin 18

1995 ◽  
Vol 73 (9-10) ◽  
pp. 635-639 ◽  
Author(s):  
Julie Fradette ◽  
Marie-Josée Godbout ◽  
Martine Michel ◽  
Lucie Germain
Keyword(s):  
Human Skin ◽  
Basal Layer ◽  
Sensory Nerve ◽  
Neurosecretory Cells ◽  
Nerve Fibers ◽  
Hair Follicles ◽  
Merkel Cells ◽  
Merkel Cell ◽  
Skin Receptor ◽  
And Function

Merkel cells are neurosecretory cells of the skin with epithelial features such as desmosomes and expression of keratins 8, 18, 19, and 20. Merkel cells are scarcely distributed in adult human skin. Although they are present in hair follicles, their density is higher at hairless anatomic sites such as palms and soles. These cells are often innervated by sensory nerve fibers and are thought to be specialized mechanosensory skin receptor cells. However, their precise origin and function are not clearly established. The aim of this study was to localize Merkel cells in human hairless and hairy skin by immunohistochemistry with antibodies Ks18.174 and Ks19.1 directed against keratins 18 and 19, respectively. In glabrous skin of palm and sole, Merkel cells have been localized at the bottom of the rete ridges, in the epidermal basal layer. To study Merkel cell distribution at hairy anatomic sites, we have chosen breast skin, a tissue containing small hair follicles typical of those covering most of the body's surface. Merkel cells were present in the interfollicular epidermis. In hair follicles, they have been identified in the isthmus region.Key words: skin, human, Merkel cell, keratin, hair follicle.

Localization of μ-opioid receptor 1A on sensory nerve fibers in human skin

2002 ◽  
Vol 110 (1) ◽  
pp. 75-83 ◽  
Author(s):  
Sonja Ständer ◽  
Matthias Gunzer ◽  
Dieter Metze ◽  
Thomas Luger ◽  
Martin Steinhoff
Keyword(s):  
Human Skin ◽  
Opioid Receptor ◽  
Sensory Nerve ◽  
Nerve Fibers ◽  
Μ Opioid Receptor

scholarly journals Adventitial Mast Cells Connect With Sensory Nerve Fibers in Atherosclerotic Coronary Arteries

Circulation ◽  
2000 ◽  
Vol 101 (14) ◽  
pp. 1665-1669 ◽  
Author(s):  
P. Laine ◽  
A. Naukkarinen ◽  
L. Heikkila ◽  
A. Penttila ◽  
P. T. Kovanen
Keyword(s):  
Mast Cells ◽  
Coronary Arteries ◽  
Sensory Nerve ◽  
Nerve Fibers

A semi-automated analysis method of small sensory nerve fibers in human skin-biopsies

2010 ◽  
Vol 185 (2) ◽  
pp. 325-337 ◽  
Author(s):  
Kazuyuki Tamura ◽  
Violet A. Mager ◽  
Lindsey A. Burnett ◽  
John H. Olson ◽  
Jeremy B. Brower ◽  
...  
Keyword(s):  
Human Skin ◽  
Sensory Nerve ◽  
Automated Analysis ◽  
Nerve Fibers ◽  
Analysis Method ◽  
Skin Biopsies

scholarly journals Axon typing of rat muscle nerves using a double staining procedure for cholinesterase and carbonic anhydrase.

1991 ◽  
Vol 39 (12) ◽  
pp. 1617-1625 ◽  
Author(s):  
M J Szabolcs ◽  
A Windisch ◽  
R Koller ◽  
M Pensch
Keyword(s):  
Carbonic Anhydrase ◽  
Cross Sections ◽  
Sensory Nerve ◽  
Histological Section ◽  
Trapezius Muscle ◽  
Motor Units ◽  
Conventional Technique ◽  
Nerve Fibers ◽  
Staining Procedure ◽  
Muscle Nerve

We developed a method for detecting activity of axonal cholinesterase (CE) and carbonic anhydrase (CA)--markers for motor and sensory nerve fibers (NFs)--in the same histological section. To reach this goal, cross-sections of muscle nerves were sequentially incubated with the standard protocols for CE and CA histochemistry. A modified incubation medium was used for CA in which Co++ is replaced by Ni++. This avoids interference of the two histochemical reactions because Co++ binds unspecifically to the brown copper-ferroferricyanide complex representing CE activity, whereas Ni++ does not. Cross-sections of the trapezius muscle nerve containing efferent and afferent NFs in segregated fascicles showed that CE activity was confined to motor NFs. Axonal CA was detected solely in sensory NFs. The number of labeled motor and sensory NFs determined in serial cross-sections stained with either the new or the conventional technique was not significantly different. Morphometric analysis revealed that small unreactive NFs (diameter less than 5 microns) are afferent, medium-sized ones (5 microns less than d less than 7 microns) are unclassifiable, and large ones (d greater than 7 microns) are efferent. The heterogenous CE activity of thick (alpha) motor NFs is linked to the type of their motor units. "Fast" motor units contain CE reactive NFs; "slow" ones have CE negative neurites.

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