The serum levels of squamous cell carcinoma antigens 1 and 2 are associated with severity and clinical types of atopic dermatitis

2016 ◽  
Vol 84 (1) ◽  
pp. e31
Author(s):  
Tomoko Okawa ◽  
Yukie Yamaguchi ◽  
Kevin Kou ◽  
Junya Ono ◽  
Yusuke Inoue ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Atopic Dermatitis ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Serum Levels

scholarly journals Squamous cell carcinoma antigens (SCCAs) are sensitive biomarkers for atopic dermatitis in children and adolescents: a cross-sectional study

2020 ◽  
Author(s):  
Junya Hirayama ◽  
Takao Fujisawa ◽  
Mizuho Nagao ◽  
Yu Kuwabara ◽  
Keigo Kainuma ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Atopic Dermatitis ◽  
Children And Adolescents ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Linear Regression Analysis ◽  
International Study ◽  
Serum Levels ◽  
Response To Treatment ◽  
Cross Sectional

Abstract Background We recently reported that squamous cell carcinoma antigen 2 (SCCA2) is a reliable biomarker for atopic dermatitis (AD) in children. To further clarify its utility, we investigated for possible effects of comorbid allergies and AD treatment on serum SCCA levels in children and adolescents.Methods Volunteers aged less than 18 years were recruited through our website. Their allergic status was elucidated using the International Study of Asthma and Allergies in Childhood (ISAAC) questionnaire. We also recruited pediatric patients who needed to be hospitalized because of severe AD. The serum levels of SCCA1 and SCCA2 were measured by ELISAs. In the severe AD patients, the levels of thymus and activation-regulated chemokine (TARC), SCCA1 and SCCA2 were measured before and after hospitalization. The severity of AD was assessed using the severity scoring of atopic dermatitis (SCORAD) index.Results A total of 576 participants (547 volunteers and 29 patients) were enrolled in the study. The levels of SCCA1 and SCCA2 were significantly higher in volunteers with mild AD and patients with severe AD than in healthy volunteers without allergic diseases. In contrast, the levels were not elevated in those who had mild bronchial asthma or mild allergic rhinitis without AD. TARC, SCCA1 and SCCA2 were decreased in patients with severe AD, reflecting clinical improvement in response to treatment. Linear regression analysis for predicting a decrease in the SCORAD index showed R2 values of 0.16, 0.38 and 0.48 for TARC, SCCA1 and SCCA2, respectively..Conclusions SCCAs, especially SCCA2, are sensitive biomarkers for detecting AD in children and adolescents, even in the mild stage, and for assessing the severity and response to treatment of severe AD.

scholarly journals Serum levels of squamous cell carcinoma antigens 1 and 2 reflect disease severity and clinical type of atopic dermatitis in adult patients

2018 ◽  
Vol 67 (1) ◽  
pp. 124-130 ◽  
Author(s):  
Tomoko Okawa ◽  
Yukie Yamaguchi ◽  
Kenzen Kou ◽  
Junya Ono ◽  
Yoshinori Azuma ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Atopic Dermatitis ◽  
Cell Carcinoma ◽  
Disease Severity ◽  
Squamous Cell ◽  
Serum Levels ◽  
Adult Patients ◽  
Clinical Type ◽  
Reflect Disease Severity

scholarly journals Serum levels of 25‐hydroxy‐vitamin D in patients with oral squamous cell carcinoma: Making a case for chemoprevention

2020 ◽  
Vol 6 (4) ◽  
pp. 428-432
Author(s):  
Samuel E. Udeabor ◽  
Abdullah M. Albejadi ◽  
Waleed A. K. Al‐Shehri ◽  
Chidozie I. Onwuka ◽  
Saeed Y. Al‐Fathani ◽  
...  
Keyword(s):  
Vitamin D ◽  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Serum Levels ◽  
25 Hydroxy Vitamin D

Squamous cell carcinoma antigen serum levels as prognostic parameter in patients with early stage vulvar cancer

2005 ◽  
Vol 97 (3) ◽  
pp. 904-907 ◽  
Author(s):  
Lukas A. Hefler ◽  
Gerhard Sliutz ◽  
Sepp Leodolter ◽  
Paul Speiser ◽  
Elmar Joura ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Vulvar Cancer ◽  
Early Stage ◽  
Serum Levels ◽  
Squamous Cell Carcinoma Antigen ◽  
Prognostic Parameter

Serum Levels of Intercellular Adhesion Molecule-1 in Squamous Cell Carcinoma of the Head and Neck

Tumor Biology ◽  
1997 ◽  
Vol 18 (2) ◽  
pp. 88-94 ◽  
Author(s):  
B. Wollenberg ◽  
N. v. Jan ◽  
W. Sautier ◽  
K. Hofmann ◽  
U.M. Schmitt ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Adhesion Molecule ◽  
Serum Levels ◽  
Intercellular Adhesion ◽  
Intercellular Adhesion Molecule ◽  
Intercellular Adhesion Molecule 1

Pulmonary Inverted Schneiderian Papilloma Causing High Serum Levels of Carcinoembryonic Antigen and Squamous Cell Carcinoma-Associated Antigen: Report of a Case

Surgery Today ◽  
2007 ◽  
Vol 37 (9) ◽  
pp. 790-793 ◽  
Author(s):  
Takashi Iwata ◽  
Kiyotoshi Inoue ◽  
Noritoshi Nishiyama ◽  
Nobuhiro Izumi ◽  
Shinjiro Mizuguchi ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Carcinoembryonic Antigen ◽  
Squamous Cell ◽  
Serum Levels ◽  
High Serum ◽  
Schneiderian Papilloma

Increased serum levels of squamous cell carcinoma-related antigen in pemphigus

1988 ◽  
Vol 118 (4) ◽  
pp. 471-474 ◽  
Author(s):  
H KUDO ◽  
M. YAMAMOTO ◽  
Y. MIYACHI ◽  
K. DANNO ◽  
S. IMAMURA
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Serum Levels

Serum Levels of Squamous Cell Carcinoma Antigen and Carcinoembryonic Antigen as Tumor Markers of Vulvar Cancer

1996 ◽  
Vol 22 (4) ◽  
pp. 341-346 ◽  
Author(s):  
Takaharu Yamawaki ◽  
Nobuhiro Takeshima ◽  
Yoshio Shimizu ◽  
Hideo Teshima ◽  
Katsuhiko Hasumi
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Carcinoembryonic Antigen ◽  
Tumor Markers ◽  
Squamous Cell ◽  
Vulvar Cancer ◽  
Serum Levels ◽  
Squamous Cell Carcinoma Antigen
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