scholarly journals Genetic expression signatures of oral submucous fibrosis and oral cancer—A preliminary microarray report

2016 ◽  
Vol 11 (4) ◽  
pp. 457-462 ◽  
Author(s):  
Pao-Hsin Liao ◽  
Hui-Wen Yang ◽  
Yu-Feng Huang
Keyword(s):  
Oral Cancer ◽  
Oral Submucous Fibrosis ◽  
Genetic Expression ◽  
Submucous Fibrosis

scholarly journals Mandibular Canal Widening and Bell’s Palsy: Sequelae of Perineural Invasion in Oral Cancer

2016 ◽  
Vol 2016 ◽  
pp. 1-4
Author(s):  
Gopinath Thilak Parepady Sundar ◽  
Vishwanath Sherigar ◽  
Sameep S. Shetty ◽  
Shree Satya ◽  
Sourabh M. Gohil
Keyword(s):  
Oral Cancer ◽  
Perineural Invasion ◽  
Oral Submucous Fibrosis ◽  
Inferior Alveolar Nerve ◽  
Mandibular Canal ◽  
Distinct Disease ◽  
Nerve Tracts ◽  
Submucous Fibrosis ◽  
Neurological Disturbance ◽  
Shed Light

Perineural invasion is an underrecognized route of metastatic spread along the nerve bundles within the nerve sheath into the surrounding tissues. It hinders the ability to establish local control as tumour cells can traverse along nerve tracts well beyond the extent of any local invasion rendering them inoperable and unresectable. Perineural invasion is a marker of poor prognosis. Oral submucous fibrosis with oral cancer constitutes a clinicopathologically distinct disease. Our case highlights an enigmatic presentation of oral submucous fibrosis and its coexistence with oral cancer presenting with unusual neurological disturbance of the inferior alveolar nerve and facial nerve and diffuse widening of the mandibular canal. The objective of this case report is to enumerate the significance of perineural invasion in determining the course of the disease and necessitate the need for future studies that can shed light on molecular mediators and pathogenesis of perineural spread.

scholarly journals Genetic Susceptibility and Protein Expression of Extracellular Matrix Turnover-Related Genes in Oral Submucous Fibrosis

2020 ◽  
Vol 21 (21) ◽  
pp. 8104
Author(s):  
Ru-Hsiu Cheng ◽  
Yi-Ping Wang ◽  
Julia Yu-Fong Chang ◽  
Yu-Hwa Pan ◽  
Mei-Chi Chang ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Oral Cancer ◽  
Genetic Susceptibility ◽  
Molecular Mechanisms ◽  
Lysyl Oxidase ◽  
Oral Submucous Fibrosis ◽  
Tissue Inhibitors Of Metalloproteinases ◽  
Contributing Factors ◽  
Plasminogen Activator Inhibitor 1 ◽  
Submucous Fibrosis

Betel quid (BQ) chewing increased the risk of oral cancer and oral submucous fibrosis (OSMF), an oral premalignant disorder (OPMD) with malignant transformation potential. BQ components such as areca nut (AN), trauma by coarse AN fiber, catechin, copper, alkaloids, stimulated reactive oxygen species (ROS), inflammation and cytotoxicity are suggested to be the contributing factors. They may induce tissue inflammation, proliferation of fibroblasts and collagen deposition, myofibroblast differentiation and contraction, collagen cross-links and inhibit collagen phagocytosis, finally leading to the development of OSMF and oral cancer. These events are mediated by BQ components-induced changes of extracellular matrix (ECM) turnover via regulation of TGF-β1, plasminogen activator inhibitor-1 (PAI-1), cystatin, lysyl oxidase (LOX) and tissue inhibitors of metalloproteinases (TIMPs) and metalloproteinases (MMPs). Genetic susceptibility is also involved in these disease processes. Further understanding the molecular mechanisms of BQ-induced OSMF and oral cancer can be helpful for future disease prevention and treatment.

scholarly journals Cross-Cheek Dumbbell-Shaped Radial Forearm Flap for Simultaneous Correction of Oral Cancer and Submucous Fibrosis

2016 ◽  
Vol 9 (2) ◽  
pp. 162-165 ◽  
Author(s):  
Shreya Bhattacharya ◽  
Sivakumar Vidhyadharan ◽  
Krishnakumar Thankappan ◽  
Subramania Iyer
Keyword(s):  
Oral Cancer ◽  
Buccal Mucosa ◽  
Oral Submucous Fibrosis ◽  
The Other ◽  
Simultaneous Occurrence ◽  
Cancer Resection ◽  
Novel Technique ◽  
Radial Forearm ◽  
Submucous Fibrosis ◽  
Interincisor Distance

Simultaneous occurrence of oral submucous fibrosis along with carcinoma of the buccal mucosa is common. We report a novel technique of a single dumbbell-shaped, cross-cheek radial forearm free flap to repair bilateral defects caused by oral cancer resection on one side and the release of fibrosis on the other side in two patients. The dumbbell-shaped flap provided tissue for both the buccal mucosa defects and central released soft palate preventing fibrosis and reapproximation. The interincisor distance improved in both the patients.

scholarly journals Study of the Role of Salivary Lactate Dehydrogenase in Habitual Tobacco Chewers, Oral Submucous Fibrosis and Oral Cancer as a Biomarker

2019 ◽  
Vol 20 (8) ◽  
pp. 970-973 ◽  
Author(s):  
Sanjay G Thete ◽  
Tejashree Mantri ◽  
Vijayalaxmi Male ◽  
Renu Yadav ◽  
Ishita Grover ◽  
...  
Keyword(s):  
Lactate Dehydrogenase ◽  
Oral Cancer ◽  
Oral Submucous Fibrosis ◽  
Submucous Fibrosis

Lactate dehydrogenase as a biomarker in oral cancer and oral submucous fibrosis

2016 ◽  
Vol 45 (9) ◽  
pp. 687-690 ◽  
Author(s):  
Basavaraj N. Kallalli ◽  
Kamala Rawson ◽  
Muzammil ◽  
Ankur Singh ◽  
Mohammed Arif Awati ◽  
...  
Keyword(s):  
Lactate Dehydrogenase ◽  
Oral Cancer ◽  
Oral Submucous Fibrosis ◽  
Submucous Fibrosis
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