scholarly journals Estimation of Superoxide Dismutase and Glutathione Peroxidase in Oral Submucous Fibrosis, Oral Leukoplakia and Oral Cancer - A Comparative Study

2012 ◽  
Vol 13 (9) ◽  
pp. 4409-4412 ◽  
Author(s):  
Shubha Gurudath ◽  
K.S. Ganapathy ◽  
Sujatha D. ◽  
Anuradha Pai ◽  
Sushmini Ballal ◽  
...  
Keyword(s):  
Superoxide Dismutase ◽  
Oral Cancer ◽  
Glutathione Peroxidase ◽  
Comparative Study ◽  
Oral Submucous Fibrosis ◽  
Oral Leukoplakia ◽  
Submucous Fibrosis

scholarly journals Superoxide dismutase and glutathione peroxidase in oral submucous fibrosis, oral leukoplakia, and oral cancer: A comparative study

2012 ◽  
Vol 4 (2) ◽  
pp. 114 ◽  
Author(s):  
Yadavalli Guruprasad ◽  
RaghavendraMahadev Naik ◽  
Anuradha Pai ◽  
D Sujatha ◽  
KS Ganapathy ◽  
...  
Keyword(s):  
Superoxide Dismutase ◽  
Oral Cancer ◽  
Glutathione Peroxidase ◽  
Comparative Study ◽  
Oral Submucous Fibrosis ◽  
Oral Leukoplakia ◽  
Submucous Fibrosis

scholarly journals Mandibular Canal Widening and Bell’s Palsy: Sequelae of Perineural Invasion in Oral Cancer

2016 ◽  
Vol 2016 ◽  
pp. 1-4
Author(s):  
Gopinath Thilak Parepady Sundar ◽  
Vishwanath Sherigar ◽  
Sameep S. Shetty ◽  
Shree Satya ◽  
Sourabh M. Gohil
Keyword(s):  
Oral Cancer ◽  
Perineural Invasion ◽  
Oral Submucous Fibrosis ◽  
Inferior Alveolar Nerve ◽  
Mandibular Canal ◽  
Distinct Disease ◽  
Nerve Tracts ◽  
Submucous Fibrosis ◽  
Neurological Disturbance ◽  
Shed Light

Perineural invasion is an underrecognized route of metastatic spread along the nerve bundles within the nerve sheath into the surrounding tissues. It hinders the ability to establish local control as tumour cells can traverse along nerve tracts well beyond the extent of any local invasion rendering them inoperable and unresectable. Perineural invasion is a marker of poor prognosis. Oral submucous fibrosis with oral cancer constitutes a clinicopathologically distinct disease. Our case highlights an enigmatic presentation of oral submucous fibrosis and its coexistence with oral cancer presenting with unusual neurological disturbance of the inferior alveolar nerve and facial nerve and diffuse widening of the mandibular canal. The objective of this case report is to enumerate the significance of perineural invasion in determining the course of the disease and necessitate the need for future studies that can shed light on molecular mediators and pathogenesis of perineural spread.

scholarly journals Expression of β-catenin in oral leukoplakia and oral submucous fibrosis: An immunohistochemical study

2021 ◽  
Vol 25 (1) ◽  
pp. 124
Author(s):  
Jaya Singh ◽  
Pritha Chowdhury ◽  
BR Nagamalini ◽  
BK Ashwini ◽  
Sharada
Keyword(s):  
Immunohistochemical Study ◽  
Oral Submucous Fibrosis ◽  
Oral Leukoplakia ◽  
Submucous Fibrosis

Comparative study of the efficacy of lycopene and aloe vera in the treatment of oral submucous fibrosis

2015 ◽  
Vol 4 (1) ◽  
pp. 13 ◽  
Author(s):  
Santosh Patil ◽  
Rohit Sahu ◽  
MG Sghaireen ◽  
SomnathReddy Kunsi ◽  
Sneha Maheshwari
Keyword(s):  
Comparative Study ◽  
Oral Submucous Fibrosis ◽  
Aloe Vera ◽  
Submucous Fibrosis

scholarly journals Genetic Susceptibility and Protein Expression of Extracellular Matrix Turnover-Related Genes in Oral Submucous Fibrosis

2020 ◽  
Vol 21 (21) ◽  
pp. 8104
Author(s):  
Ru-Hsiu Cheng ◽  
Yi-Ping Wang ◽  
Julia Yu-Fong Chang ◽  
Yu-Hwa Pan ◽  
Mei-Chi Chang ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Oral Cancer ◽  
Genetic Susceptibility ◽  
Molecular Mechanisms ◽  
Lysyl Oxidase ◽  
Oral Submucous Fibrosis ◽  
Tissue Inhibitors Of Metalloproteinases ◽  
Contributing Factors ◽  
Plasminogen Activator Inhibitor 1 ◽  
Submucous Fibrosis

Betel quid (BQ) chewing increased the risk of oral cancer and oral submucous fibrosis (OSMF), an oral premalignant disorder (OPMD) with malignant transformation potential. BQ components such as areca nut (AN), trauma by coarse AN fiber, catechin, copper, alkaloids, stimulated reactive oxygen species (ROS), inflammation and cytotoxicity are suggested to be the contributing factors. They may induce tissue inflammation, proliferation of fibroblasts and collagen deposition, myofibroblast differentiation and contraction, collagen cross-links and inhibit collagen phagocytosis, finally leading to the development of OSMF and oral cancer. These events are mediated by BQ components-induced changes of extracellular matrix (ECM) turnover via regulation of TGF-β1, plasminogen activator inhibitor-1 (PAI-1), cystatin, lysyl oxidase (LOX) and tissue inhibitors of metalloproteinases (TIMPs) and metalloproteinases (MMPs). Genetic susceptibility is also involved in these disease processes. Further understanding the molecular mechanisms of BQ-induced OSMF and oral cancer can be helpful for future disease prevention and treatment.

scholarly journals Aberrant DKK3 expression in the oral leukoplakia and oral submucous fibrosis: a comparative immunohistochemical study

2016 ◽  
Author(s):  
T. Al-dhohorah ◽  
M. Mashrah ◽  
Z. Yao ◽  
J. Huang
Keyword(s):  
Histological Grade ◽  
Oral Submucous Fibrosis ◽  
Suppressor Gene ◽  
Oral Leukoplakia ◽  
Premalignant Lesions ◽  
Severe Dysplasia ◽  
Normal Oral Mucosa ◽  
Significant Difference ◽  
Risk Of Progression ◽  
Submucous Fibrosis

We aimed to assess and compare the expression of Dickkopf homolog 3 (DKK3), a possible tumor suppressor gene (TSG), in oral leukoplakia (OLK) and oral submucous fibrosis (OSF) using immunohistochemistry. Seventy-five cases of normal oral mucosa (NOM), OLK, OSF, and squamous cell carcinoma (OSCC) were studied. DKK3 was expressed in all cases of NOM, OLK and OSCC. There was steady increases in the percentage of the positive cells progressing toward OSCC. The expression was localized in the cytoplasm and cell membrane of cell affected by OLK with mild dysplasia and OLK with severe dysplasia. No significant association was observed between DKK3 expression and dysplastic status of OLK. Loss of DKK3 expression was observed in 15 of 30 cases in the OSF group, which was significantly associated with histological grade of OSF (P<0.0001). The percentage of positive cells gradually declined with the increasing severity of epithelial atrophy. A significant difference (P<0.01) was observed when comparing DKK3 expression among different groups of OLK and OSF cases. DKK3 may have diverse expressions in oral premalignant lesions. Loss of DKK3 expression in dysplastic/advanced stage of OSF may imply a high risk of progression to oral cancer.

Consumption of areca quid, cigarettes, and alcohol related to the comorbidity of oral submucous fibrosis and oral cancer

2007 ◽  
Vol 104 (5) ◽  
pp. 647-652 ◽  
Author(s):  
Pei-Shan Ho ◽  
Yi-Hsin Yang ◽  
Tien-Yu Shieh ◽  
I.-Yueh Huang ◽  
Yun-Kwan Chen ◽  
...  
Keyword(s):  
Oral Cancer ◽  
Oral Submucous Fibrosis ◽  
Submucous Fibrosis
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