A novel approach with glass needle enclosed movable probe for in vivo real-time detection of glucose in cisternal cerebrospinal fluid

2020 ◽  
Vol 873 ◽  
pp. 114440
Author(s):  
Jie Tao ◽  
Ying Zhu ◽  
Shuainan Zhao ◽  
Peihua Chen ◽  
Shuli Zhang ◽  
...  
2021 ◽  
Author(s):  
Qiuying Song ◽  
Bo Zhou ◽  
Dongyu Zhang ◽  
Haijun Chi ◽  
Hongmin Jia ◽  
...  

The development of well-designed fluorescence probes for the monitoring redox homeostasis in biosystems has become a desired research field owing to their noninvasive and real-time detection capability in vivo. In...


2019 ◽  
Vol 5 (5) ◽  
pp. eaan9388 ◽  
Author(s):  
Yimei Huang ◽  
Zhenguo Wu ◽  
Harvey Lui ◽  
Jianhua Zhao ◽  
Shusen Xie ◽  
...  

We report a novel approach to selectively close single blood vessels within tissue using multiphoton absorption–based photothermolysis (multiphoton photothermolysis) without the need of exogenous agents. The treatment process is monitored by in vivo reflectance confocal microscopy in real time. Closure of single targeted vessels of varying sizes ranging from capillaries to venules was demonstrated. We also demonstrated that deeply situated blood vessels could be closed precisely while preserving adjacent overlying superficial blood vessels. In vivo confocal Raman spectroscopy of the treatment sites confirmed vessel closure as being mediated by local coagulative damage. Partial vessel occlusion could be achieved, and it is accompanied by increased intravascular blood cell speed. Multiphoton photothermolysis under real-time reflectance confocal imaging guidance provides a novel precision medicine approach for noninvasive, precise microsurgery treatment of vascular diseases on a per-vessel/per-lesion basis. The method could also be used for building ischemic stroke models for basic biology study.


2018 ◽  
Vol 33 (6) ◽  
pp. 1811-1817 ◽  
Author(s):  
David Benjamin Ellebrecht ◽  
Christiane Kuempers ◽  
Marco Horn ◽  
Tobias Keck ◽  
Markus Kleemann

2007 ◽  
Vol 12 (2) ◽  
pp. 020507 ◽  
Author(s):  
Steven Boutrus ◽  
Cherry Greiner ◽  
Derrick Hwu ◽  
Michael Chan ◽  
Charlotte Kuperwasser ◽  
...  

2020 ◽  
Vol 34 (S1) ◽  
pp. 1-1
Author(s):  
Colin H. Brown ◽  
Ranjan K. Roy ◽  
Jordan P. Hamm ◽  
Javier E. Stern

2020 ◽  
Vol 6 (11) ◽  
pp. eaay1729 ◽  
Author(s):  
Saswat Mishra ◽  
Yun-Soung Kim ◽  
Jittrapol Intarasirisawat ◽  
Young-Tae Kwon ◽  
Yongkuk Lee ◽  
...  

Recent advancements in electronic packaging and image processing techniques have opened the possibility for optics-based portable eye tracking approaches, but technical and safety hurdles limit safe implementation toward wearable applications. Here, we introduce a fully wearable, wireless soft electronic system that offers a portable, highly sensitive tracking of eye movements (vergence) via the combination of skin-conformal sensors and a virtual reality system. Advancement of material processing and printing technologies based on aerosol jet printing enables reliable manufacturing of skin-like sensors, while the flexible hybrid circuit based on elastomer and chip integration allows comfortable integration with a user’s head. Analytical and computational study of a data classification algorithm provides a highly accurate tool for real-time detection and classification of ocular motions. In vivo demonstration with 14 human subjects captures the potential of the wearable electronics as a portable therapy system, whose minimized form factor facilitates seamless interplay with traditional wearable hardware.


2018 ◽  
Vol 10 (33) ◽  
pp. 4079-4084 ◽  
Author(s):  
Xilang Jin ◽  
Xianglong Wu ◽  
Pu Xie ◽  
Sha Liu ◽  
Jie Wu ◽  
...  

The probe exhibited high sensitivity, selectivity, and fast response for real-time detection of H2S in vivo.


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