Long-term Natural History of Chronic Obstructive Pulmonary Disease: Severe Exacerbations and Mortality

2013 ◽  
Vol 44 (5) ◽  
pp. 1060
Author(s):  
Michael Ruygrok
2017 ◽  
Vol 3 (4) ◽  
pp. 00117-2017 ◽  
Author(s):  
Alvar Agustí ◽  
Bartolomé Celli

Understanding the natural history of a disease is as important as knowing its cause(s) for effective disease prevention and treatment. Yet, our current understanding of the natural history of chronic obstructive pulmonary disease (COPD) is incomplete and often controversial. This article discusses the current gaps, and hence opportunities for research, in this field. In particular, it discusses the following six specific questions. 1) Is COPD a “single” disease? 2) Is COPD “only” a lung disease? 3) When does COPD begin or what is “early” COPD? 4) How does COPD “progress”? 5) How do we assess disease “severity”? 6) Can COPD be prevented (beyond smoking cessation) or its course be modified once detected?


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