Safflower seed oil improves steroidogenesis and spermatogenesis in rats with type II diabetes mellitus by modulating the genes expression involved in steroidogenesis, inflammation and oxidative stress

2021 ◽  
pp. 114139
Author(s):  
Khadijeh Nasiri ◽  
Abolfazl Akbari ◽  
Majid Nimrouzi ◽  
Maede Ruyvaran ◽  
Alireza Mohamadian
Keyword(s):  
Oxidative Stress ◽  
Diabetes Mellitus ◽  
Type Ii Diabetes ◽  
Seed Oil ◽  
Type Ii Diabetes Mellitus ◽  
Safflower Seed ◽  
Type Ii ◽  
Safflower Seed Oil ◽  
Genes Expression ◽  
And Oxidative Stress

scholarly journals The Nrf2/Keap1/ARE Pathway and Oxidative Stress as a Therapeutic Target in Type II Diabetes Mellitus

2017 ◽  
Vol 2017 ◽  
pp. 1-15 ◽  
Author(s):  
Joshua A. David ◽  
William J. Rifkin ◽  
Piul S. Rabbani ◽  
Daniel J. Ceradini
Keyword(s):  
Diabetes Mellitus ◽  
Oxidative Damage ◽  
Therapeutic Target ◽  
Type Ii Diabetes ◽  
Animal Studies ◽  
Cell Types ◽  
Type Ii Diabetes Mellitus ◽  
Type Ii ◽  
And Oxidative Stress

Despite improvements in awareness and treatment of type II diabetes mellitus (TIIDM), this disease remains a major source of morbidity and mortality worldwide, and prevalence continues to rise. Oxidative damage caused by free radicals has long been known to contribute to the pathogenesis and progression of TIIDM and its complications. Only recently, however, has the role of the Nrf2/Keap1/ARE master antioxidant pathway in diabetic dysfunction begun to be elucidated. There is accumulating evidence that this pathway is implicated in diabetic damage to the pancreas, heart, and skin, among other cell types and tissues. Animal studies and clinical trials have shown promising results suggesting that activation of this pathway can delay or reverse some of these impairments in TIIDM. In this review, we outline the role of oxidative damage and the Nrf2/Keap1/ARE pathway in TIIDM, focusing on current and future efforts to utilize this relationship as a therapeutic target for prevention, prognosis, and treatment of TIID.

scholarly journals COMPARATIVE ASSESSMENT OF METHODS OF ESTIMATION OF SUPEROXIDE DISMUTASE (SOD) IN TERMS OF SENSITIVITY AND SPECIFICTY IN TYPE-II DIABETES MELLITUS.

2019 ◽  
Vol 3 (7) ◽  
Author(s):  
Mr. Pravinkumar Sonawane ◽  
Dr. R.V. KatKam ◽  
Dr. V. S. Shinde ◽  
Dr. S. A. Abhang
Keyword(s):  
Oxidative Stress ◽  
Diabetes Mellitus ◽  
Superoxide Dismutase ◽  
Free Radical ◽  
Type Ii Diabetes ◽  
Microvascular Complications ◽  
Type Ii Diabetes Mellitus ◽  
Comparative Assessment ◽  
Type Ii ◽  
Good Marker

Now a days it is a known fact that the oxidative stress is in the foreground of type-II diabetes mellitus. It is the main cause of macro and microvascular complications in type II diabetes mellitus. Oxidative stress can be served as a good marker of degree of diabetes in addition is HbA1C. Superoxide (O2.- ) is one of the free radical produced during oxidative stress.  Superoxide dismutase (SOD) is an enzyme which quenches superoxide radicals produced due to oxidative stress. Hence it is very obvious that the estimation of SOD should be very sensitive and specific. To attain this aim we compared three different methods. Key words: SOD, Diabetes, Oxidative stress, Superoxide Dismutase.

Oxidative stress and nitric oxide related parameters in type II diabetes mellitus: effects of glycemic control

2001 ◽  
Vol 34 (1) ◽  
pp. 65-70 ◽  
Author(s):  
Ahmet Aydın ◽  
Hilmi Orhan ◽  
Ahmet Sayal ◽  
Metin Özata ◽  
Gönül Şahin ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Nitric Oxide ◽  
Diabetes Mellitus ◽  
Glycemic Control ◽  
Type Ii Diabetes ◽  
Type Ii Diabetes Mellitus ◽  
Type Ii
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